TUFM

TUFM
Identifiers
Aliases	TUFM , COXPD4, EF-TuMT, EFTU, P43, Tu translation elongation factor, mitochondrial
External IDs	OMIM: 602389; MGI: 1923686; HomoloGene: 2490; GeneCards: TUFM; OMA:TUFM - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 28,842,411 bp [1] End 28,846,348 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 126,086,533 bp [2] End 126,089,903 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon apex of heart right adrenal gland left adrenal gland body of pancreas body of stomach right adrenal cortex left adrenal cortex olfactory zone of nasal mucosa granulocyte Top expressed in right kidney muscle of thigh neural layer of retina yolk sac lip embryo dentate gyrus of hippocampal formation granule cell ventricular zone embryo blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding translation elongation factor activity RNA binding GTPase activity Cellular component mitochondrial nucleoid extracellular exosome intracellular anatomical structure mitochondrion membrane mitochondrial inner membrane myelin sheath synapse Biological process translational elongation protein biosynthesis response to ethanol mitochondrial translational elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7284 233870 Ensembl ENSG00000178952 ENSMUSG00000073838 UniProt P49411 Q8BFR5 RefSeq (mRNA) NM_003321 NM_001365360 NM_001163713 NM_172745 RefSeq (protein) NP_003312 NP_001352289 NP_001157185 NP_766333 Location (UCSC) Chr 16: 28.84 – 28.85 Mb Chr 7: 126.09 – 126.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Elongation factor Tu, mitochondrial is a protein that in humans is encoded by the TUFM gene. It is an EF-Tu homolog. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000178952 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073838 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ling M, Merante F, Chen HS, Duff C, Duncan AM, Robinson BH (Nov 1997). "The human mitochondrial elongation factor tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene". Gene. 197 (1–2): 325–36. doi:10.1016/S0378-1119(97)00279-5. PMID   9332382.
6. Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT (Jun 1998). "Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus". Genomics. 48 (3): 384–8. doi:10.1006/geno.1997.5166. PMID   9545647.
7. "Entrez Gene: TUFM Tu translation elongation factor, mitochondrial".

Further reading

• Wells J, Henkler F, Leversha M, Koshy R (1995). "A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues". FEBS Lett. 358 (2): 119–25. doi: 10.1016/0014-5793(94)01403-N . PMID   7828719. S2CID   24769779.
• Woriax VL, Burkhart W, Spremulli LL (1996). "Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu". Biochim. Biophys. Acta. 1264 (3): 347–56. doi:10.1016/0167-4781(95)00176-x. PMID   8547323.
• Chang SY, Park SG, Kim S, Kang CY (2002). "Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation". J. Biol. Chem. 277 (10): 8388–94. doi: 10.1074/jbc.M108792200 . PMID   11741979.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Blagoev B, Kratchmarova I, Ong SE, et al. (2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. PMID   12577067. S2CID   26838266.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID   15952740.
• Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA (2006). "The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1". Hum. Mol. Genet. 15 (11): 1835–46. doi: 10.1093/hmg/ddl106 . PMID   16632485.
• Smeitink JA, Elpeleg O, Antonicka H, et al. (2006). "Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs". Am. J. Hum. Genet. 79 (5): 869–77. doi:10.1086/508434. PMC   1698578 . PMID   17033963.
• Valente L, Tiranti V, Marsano RM, et al. (2007). "Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu". Am. J. Hum. Genet. 80 (1): 44–58. doi:10.1086/510559. PMC   1785320 . PMID   17160893.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.