TVP23B

TVP23B
Identifiers
Aliases	TVP23B , FAM18B, FAM18B1, NPD008, YDR084C, CGI-148, trans-golgi network vesicle protein 23 homolog B (S. cerevisiae), trans-golgi network vesicle protein 23 homolog B
External IDs	MGI: 1914760; HomoloGene: 128511; GeneCards: TVP23B; OMA:TVP23B - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p11.2 Start 18,781,111 bp [1] End 18,806,714 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B2 Start 62,770,281 bp [2] End 62,807,606 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans Achilles tendon stromal cell of endometrium mucosa of esophagus gonad olfactory zone of nasal mucosa body of pancreas rectum anterior pituitary gallbladder Top expressed in otolith organ utricle vestibular sensory epithelium superior cervical ganglion lobe of prostate olfactory epithelium parotid gland seminal vesicula ciliary body submandibular gland More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 51030 67510 Ensembl ENSG00000171928 ENSMUSG00000014177 UniProt Q9NYZ1 Q9D8T4 RefSeq (mRNA) NM_016078 NM_001316919 NM_001316920 NM_001316921 NM_001316922 NM_001316923 NM_001316924 NM_026210 NM_001356520 NM_001356521 RefSeq (protein) NP_001303848 NP_001303849 NP_001303850 NP_001303851 NP_001303852 NP_001303853 NP_057162 NP_080486 NP_001343449 NP_001343450 Location (UCSC) Chr 17: 18.78 – 18.81 Mb Chr 11: 62.77 – 62.81 Mb PubMed search [3] [4]
Wikidata
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Golgi apparatus membrane protein TVP23 homolog B is a protein encoded by the gene TVP23B.

This gene has two paralog in the human genome, TVP23C, which is located on chromosome 17 at 17p12, and TVP23A, which is located on chromosome 16. The duplication appears to have appeared after the MRCA of humans and apes. This gene has homologs in eukaryotes as far back as Trichoplax.

Gene

TVP23B is highly conserved in chordates and also shows conservation in eukaryotes, including fungi and plants. ^[5] The most common mRNA has 7 exons.

Protein

This gene encode a protein of 205 amino acids in length and a predicted molecular weight of 23.57 kDa. This protein is predicted to have an isoelectric point of 8.62. It contains a domain of unknown function, DUF846, and a predicted phosphoserine site. ^[6] It is a multipass transmembrane protein and a member of the FAM18/TVP23 superfamily.

TVP23B appears to be ubiquitously expressed in all tissues, health states, and developmental stages to some level. There is also notable expression in bladder tissue. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171928 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000014177 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Pre-computed BLAST results for LOC51030 [Homo sapiens]". BLINK ("BLAST Link"). National Center for Biotechnology Information, United States National Institutes of Health. Archived from the original on December 14, 2012.
6. "UniProt Database".
7. "EST Profile Database". Archived from the original on December 12, 2012.