TXNL4B

TXNL4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XBS, 3GIX, 4IN0
Identifiers
Aliases	TXNL4B , DLP, Dim2, thioredoxin like 4B
External IDs	OMIM: 617722; MGI: 2443724; HomoloGene: 9880; GeneCards: TXNL4B; OMA:TXNL4B - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.2 Start 72,044,289 bp [1] End 72,094,431 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 D3 Start 110,292,524 bp [2] End 110,300,683 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus gonad monocyte optic nerve pancreatic ductal cell left ovary right lobe of liver endothelial cell secondary oocyte testicle Top expressed in granulocyte spermatid spermatocyte zygote otolith organ utricle seminiferous tubule secondary oocyte submandibular gland embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component U5 snRNP nucleus nucleoplasm cytosol spliceosomal complex U4/U6 x U5 tri-snRNP complex Biological process mRNA splicing, via spliceosome cell cycle mRNA processing spliceosomal complex assembly RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54957 234723 Ensembl ENSG00000140830 ENSMUSG00000031723 UniProt Q9NX01 Q8BUH1 RefSeq (mRNA) NM_017853 NM_001142317 NM_001142318 NM_001324354 NM_001324355 NM_175646 RefSeq (protein) NP_001135789 NP_001135790 NP_001311283 NP_001311284 NP_060323 NP_783577 Location (UCSC) Chr 16: 72.04 – 72.09 Mb Chr 8: 110.29 – 110.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thioredoxin-like protein 4B is a protein that in humans is encoded by the TXNL4B gene. ^{[5] [6]}

Interactions

TXNL4B has been shown to interact with PRPF6. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000140830 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031723 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sun X, Zhang H, Wang D, Ma D, Shen Y, Shang Y (Jul 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J Biol Chem. 279 (31): 32839–47. doi: 10.1074/jbc.M402522200 . PMID   15161931.
6. "Entrez Gene: TXNL4B thioredoxin-like 4B".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (2001). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily" (PDF). Physiol. Genomics. 1 (3): 109–18. doi:10.1152/physiolgenomics.1999.1.3.109. PMID   11015569. S2CID   16086223. Archived from the original (PDF) on 2016-03-06. Retrieved 2015-08-01.
• Schelling P, Claus MT, Johner R, Marquez VE, Schulz GE, Scapozza L (2004). "Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells". J. Biol. Chem. 279 (31): 32832–8. doi: 10.1074/jbc.M313343200 . PMID   15163659.
• Simeoni F, Arvai A, Bello P, Gondeau C, Hopfner KP, Neyroz P, Heitz F, Tainer J, Divita G (2005). "Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2". Biochemistry. 44 (36): 11997–2008. doi:10.1021/bi050427o. PMID   16142897.
• Jin T, Howard AJ, Golemis EA, Wang Y, Zhang YZ (2006). "Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B". Acta Crystallographica Section F. 61 (Pt 3): 282–4. doi:10.1107/S1744309105002861. PMC   1952293 . PMID   16511018.