Interstate 65 (I-65) is a major north–south interstate highway in the central United States. As with most primary interstates ending in 5, it is a major crosscountry, north–south route, connecting between the Great Lakes and the Gulf of Mexico. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with US 12 (US 12) and US 20 in Gary, Indiana, just southeast of Chicago. I-65 connects several major metropolitan areas in the Midwest and Southern US. It connects the four largest cities in Alabama: Mobile, Montgomery, Birmingham, and Huntsville. It also serves as one of the main north–south routes through Nashville, Tennessee; Louisville, Kentucky; and Indianapolis, Indiana, each a major metropolitan area in its respective state.
U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is at an intersection with US 90/US 98 in Spanish Fort, Alabama. Its northern terminus is at an interchange with Interstate 75 (I-75) south of Mackinaw City, Michigan.
U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama, to US 25W/US 70 in Newport, Tennessee. US 411 travels through northeastern Alabama, northwestern Georgia, and southeastern Tennessee. It is signed north-south, as with most highways that have odd numbers, but the route runs primarily in a northeast-southwest direction, and covers a more east-west mileage than it does north-south. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Maryville, Tennessee; Sevierville, Tennessee, and Newport, Tennessee.
U.S. Route 231 (US 231) is a north–south U.S highway that is a parallel route of US 31. It runs for 912 miles (1,468 km) from St. John, Indiana, at US 41 to south of US 98 in downtown Panama City, Florida. One of its most notable landmarks is the William H. Natcher Bridge, a 0.853 miles (1.373 km) long cable-stayed bridge that connects Rockport, Indiana, to Owensboro, Kentucky, spanning the Ohio River.
State Route 155, mostly designated as Briley Parkway, is a major freeway and parkway beltway around Nashville, Tennessee. It is 35.1 miles (56.5 km) long.
State Route 24 is an unsigned west–east state highway in Tennessee, as it coincides with U.S. Route 70 and U.S. Route 70N for its entire duration from Nashville to Crossville. The road begins in western Nashville and ends in Crossville. It runs alongside Interstate 40 for its entire length.
U.S. Route 31E (US 31E) is the eastern parallel route for U.S. Highway 31 from Nashville, Tennessee, to Louisville, Kentucky.
U.S. Route 31W is the westernmost of two parallel routes for U.S. Route 31 from Nashville, Tennessee to Louisville, Kentucky.
State Route 265 is a state highway in Davidson and Wilson counties in Middle Tennessee. It runs from SR 45 in Hermitage, through middle Tennessee to its eastern terminus at US Route 70 (US 70) outside of Watertown.
State Route 266 is a state highway in Middle Tennessee. The southern terminus is in a currently undeveloped section of Smyrna at an interchange with I-24. The northern terminus is in Lebanon at an intersection with US 70.
Interstate 65 (I-65) is part of the Interstate Highway System that runs 887.30 miles (1,427.97 km) north–south from Mobile, Alabama, to Gary, Indiana. In Tennessee, I-65 traverses the middle portion of the state, running from Ardmore at the Alabama border to the Kentucky border near Portland. The route serves the state capital and largest city of Nashville, along with many of its suburbs. Outside of urban areas, the Interstate bypasses most cities and towns that it serves, instead providing access via state and U.S. Highways. The Interstate passes through the Highland Rim and Nashville Basin physiographic regions of Tennessee, and is often used as the dividing line between the eastern and western portions of the former.
State Route 20 (SR 20) is a 143.04-mile (230.20 km) long east–west primary state highway that begins in Dyersburg and ending near Summertown. SR 20 is unsigned and concurrent with U.S. Route 412 (US 412) for its entire length, except for a short section between Hohenwald and Summertown. Along its route, SR 20 traverses parts of both Middle Tennessee and West Tennessee.
State Route 45 is a west–east route in Davidson County, Tennessee. It connects US 431 in Whites Creek with I-40 in Hermitage.
State Route 10 is a south–north route from the Alabama state line in Lincoln County to the Kentucky state line in Macon County.
State Route 76 (SR 76) is a state highway in Tennessee, traversing the state in a northeast-southwest axis from east of Memphis to north of Nashville. SR 76 is unique in that it actually changes its cardinal directions in Clarksville at the junction with US 41A and US 41A Bypass.
In Tennessee, U.S. Route 412 stretches for 181.93 miles (292.79 km) through the farmland of West Tennessee and the hills of Middle Tennessee, starting at the Missouri state line near Dyersburg and running to an interchange between I-65 and SR 99 in Columbia.
State Route 186 is a state highway in the U.S. state of Tennessee. It runs from Trenton southward to Jackson, passing through the towns of Gibson and Three Way along the way. The southern portion serves as a western bypass for the city of Jackson, which is signed as U.S. Route 45 Bypass.
U.S. Route 231 in Tennessee runs north–south for 121.15 miles (194.97 km), entirely in Middle Tennessee, that starts south of Fayetteville at the Alabama state line, and ends north of Westmoreland at the Kentucky state line. For the majority of its length, between the Alabama state line and Trousdale County, it is concurrent with unsigned State Route 10.
State Route 174 (SR 174) is a secondary east–west state highway in northern Middle Tennessee. It traverses northern Davidson and much of Sumner counties.
U.S. Route 31 (US 31) is a part of the United States Numbered Highway System that runs from Spanish Fort, Alabama, to Mackinaw City, Michigan. In the U.S. state of Tennessee, it runs concurrently with Interstate 65 (I-65) for the first mile northward from the Tennessee state line. There US 31 parallels I-65 to downtown Nashville. At Pulaski US 31 meets the southern terminus of US 31A in Tennessee. US 31 continues due north through Lynnville, Columbia, Spring Hill, Franklin and Brentwood to Nashville. The route splits into US 31E and US 31W in Nashville and goes into Kentucky.
I-840 / SR 265 in Lebanon 
I-65 in Portland
