Interstate 65 (I-65) is a major north–south Interstate Highway in the central United States. As with most primary Interstates ending in 5, it is a major crosscountry, north–south route, connecting between the Great Lakes and the Gulf of Mexico. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with US 12 (US 12), and US 20 in Gary, Indiana, just southeast of Chicago. I-65 connects several major metropolitan areas in the Midwest and Southern US. It connects the four largest cities in Alabama: Mobile, Montgomery, Birmingham, and Huntsville. It also serves as one of the main north–south routes through Nashville, Tennessee; Louisville, Kentucky; and Indianapolis, Indiana, each a major metropolitan area in its respective state.
U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is at an intersection with US 90/US 98 in Spanish Fort, Alabama. Its northern terminus is at an interchange with Interstate 75 (I-75) south of Mackinaw City, Michigan.
U.S. Route 231 (US 231) is a north-south U.S highway that is a parallel route of US 31. It runs for 912 miles (1,468 km) from St. John, Indiana, at US 41 to south of US 98 in downtown Panama City, Florida. One of its most notable landmarks is the William H. Natcher Bridge, a 0.853 miles (1.373 km) long cable-stayed bridge that connects Rockport, Indiana, to Owensboro, Kentucky, spanning the Ohio River.
State Route 155, mostly designated as Briley Parkway, is a major freeway and parkway beltway around Nashville, Tennessee. It is 35.1 miles (56.5 km) long.
Kentucky Route 61 is a 151.333-mile (243.547 km) long Kentucky State Highway extending north from the Tennessee state line in Cumberland County to Columbia in Adair County through to Greensburg in Green County. From there, the route traverses LaRue, Hardin and Bullitt counties to terminate in Jefferson County at the junction of U.S. Route 31E in downtown Louisville.
Kentucky Route 3005 serves as a northern bypass of Elizabethtown. Locally, it is known as Ring Road. It originates outside the western limits of Elizabethtown at an interchange with Western Kentucky Parkway. The road then takes a wide circuit to the north of the city, eventually entering the city limits. Its eastern terminus is at U.S. 62, here known as Mulberry Street, within the city limits and approximately 1 mile (1.6 km) west of Interstate 65.
U.S. Route 31E (US 31E) is the eastern parallel route for U.S. Highway 31 from Nashville, Tennessee, to Louisville, Kentucky.
Kentucky Route 44 is a 70.193 mile (112.965 km) long state highway in the U.S. state of Kentucky managed and maintained by the Kentucky Transportation Cabinet.
State Route 109 is a primary state highway in Middle Tennessee. It runs from the intersection of SR 265 and Interstate 840 near Lebanon, north through Gallatin to the Kentucky state line and I-65.
Kentucky Route 90 is a major east–west state highway in southern Kentucky. The route is 134.734 miles (216.833 km) long, and it traverses Barren, Metcalfe, Cumberland, Clinton, Wayne, Pulaski, McCreary and Whitley Counties in southern Kentucky. It runs from the KY 70 junction near Interstate 65 in Cave City to US 25W about 8 miles (13 km) from Interstate 75.
Kentucky Route 70 (KY 70) is a long east-east state highway that originates at a junction with U.S. Route 60 (US 60) in Smithland in Livingston County, just east of the Ohio River. The route continues through the counties of Crittenden, Caldwell, Hopkins, Muhlenberg, Butler, Edmonson, Barren, Barren, Metcalfe, Green, Taylor, Casey, Pulaski, Lincoln and back into Pulaski again to terminate at a junction with US 150 near Maretburg in Rockcastle.
State Route 52 is an east–west state highway that crosses eight counties in northern and northeastern Tennessee. The 141.4-mile-long (227.6 km) route originates in Orlinda along SR 49 and ends in Elgin along U.S. Route 27.
Interstate 65 (I-65) is part of the Interstate Highway System that runs 887.30 miles (1,427.97 km) north–south from Mobile, Alabama, to Gary, Indiana. In Tennessee, I-65 traverses the middle portion of the state, running from Ardmore at the Alabama border to the Kentucky border near Portland. The route serves the state capital and largest city of Nashville, along with many of its suburbs. Outside of urban areas, the Interstate bypasses most cities and towns that it serves, instead providing access via state and U.S. Highways. The Interstate passes through the Highland Rim and Nashville Basin physiographic regions of Tennessee, and is often used as the dividing line between the eastern and western portions of the former.
Interstate 65 (I-65) enters the US state of Kentucky from Tennessee, five miles (8.0 km) south of Franklin. It passes by the major cities of Bowling Green, Elizabethtown, and Louisville before exiting the state into Indiana.
U.S. Route 150 (US 150) in Kentucky is a 121.097-mile-long (194.887 km) east–west highway that runs from the Indiana state line above the Ohio River to US 25/KY 1249 at Mount Vernon.
U.S. Route 431 in Tennessee totals an estimated 116 miles (187 km) through Lincoln, Marshall, Maury, Williamson, Davidson, and Robertson counties in Middle Tennessee.
U.S. Route 231 in Kentucky runs 86.465 miles (139.152 km) from the Tennessee state line near Adolphus to the William H. Natcher Bridge on the Ohio River near Rockport, Indiana. It crosses the state mainly in the west-central region, traversing Allen, Warren, Butler, Ohio, and Daviess Counties.
Kentucky Route 218 is a 31.113-mile-long (50.072 km) west-east state highway that traverses three counties in south-central Kentucky. It is locally known as LeGrande Highway from Horse Cave to near Shady Grove.
State Route 174 (SR 174) is a secondary east–west state highway in northern Middle Tennessee. It traverses northern Davidson and much of Sumner counties.
U.S. Route 31 (US 31) is a part of the United States Numbered Highway System that runs from Spanish Fort, Alabama, to Mackinaw City, Michigan. In the U.S. state of Tennessee, it runs concurrently with Interstate 65 (I-65) for the first mile northward from the Tennessee state line. There US 31 parallels I-65 to downtown Nashville. At Pulaski US 31 meets the southern terminus of US 31A in Tennessee. US 31 continues due north through Lynnville, Columbia, Spring Hill, Franklin and Brentwood to Nashville. The route splits into US 31E and US 31W in Nashville and go into Kentucky.
US 31 / US 31E / US 41 / US 431 in Nashville, TN 
US 31 / US 31E / US 60 in Louisville, KY 
