U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama, to US 25W/US 70 in Newport, Tennessee. US 411 travels through northeastern Alabama, northwestern Georgia, and southeastern Tennessee. It is signed north-south, as with most highways that have odd numbers, but the route runs primarily in a northeast-southwest direction, and covers a more east-west mileage than it does north-south. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Maryville, Tennessee; Sevierville, Tennessee, and Newport, Tennessee.
U.S. Route 11W (US 11W) is the western branch of US 11 from the twin cities of Bristol, Tennessee/Bristol, Virginia, where US 11 splits into US 11E and US 11W, to Knoxville, Tennessee, where the two highways rejoin. The highway serves the Appalachia region's Ridge-and-Valley section of East Tennessee, bounded by the Clinch Mountain ridge to the north and the Holston River to the south. US 11W from Bristol to Bean Station and Blaine to Knoxville are designated as part of the National Highway System.
U.S. Route 25E (US 25E) is the eastern branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin. The highway, however, continues as US 25E for roughly two miles (3.2 km) until it joins Interstate 75 (I-75) in the Laurel County community of North Corbin at exit 29. The highway serves the Appalachia regions of Kentucky's Cumberland Plateau and the Ridge-and-Valley section of East Tennessee, including the urbanized areas of Corbin and Middlesboro in Kentucky and Morristown in Tennessee.
State Route 331 is a mostly west–east, signed north–south, secondary highway in Knox County in the U.S. state of Tennessee.
State Route 22 is a 172.8-mile long (278.1 km) south-to-north state highway in the western part of Tennessee, United States. It begins at the Mississippi state line in McNairy County, where the roadway continues as Mississippi Highway 2. It ends at the Kentucky state line in Lake County, when it crosses into the Kentucky Bend, a detached portion of Fulton County, Kentucky. The monument for the 1862 Battle of Island Number Ten in the American Civil War is located on SR 22, about 3 mi (4.8 km) north of Tiptonville.
U.S. Route 19 (US 19) is a part of the United States Numbered Highway System that runs from Memphis, Florida, to Erie, Pennsylvania. In Virginia, the highway runs 88.89 miles (143.05 km) between two pairs of twin cities: Bristol, Tennessee, and Bristol, Virginia, at the Virginia–Tennessee state line, and Bluefield, Virginia, and Bluefield, West Virginia, at the Virginia–West Virginia state line. Between its endpoints, US 19 has lengthy concurrencies with US 11, US 58 Alternate, and US 460 during its course connecting Abingdon, Lebanon, and Tazewell within Washington, Russell, and Tazewell counties in Southwest Virginia.
State Route 66 is a state-maintained highway in eastern Tennessee, including a six-lane divided highway known as Winfield Dunn Parkway in Sevier County, a four-lane expressway in Hamblen and Jefferson counties and a two-lane rural collector through mountainous terrain continuing to the northeast terminus in Hancock County.
State Route 14 is a south–north route from the Mississippi border in Memphis, Tennessee to an intersection with State Route 54 in Tipton County.
State Route 62 is a 87.5-mile-long (140.8 km) west-to-east highway in the U.S. state of Tennessee. It is designated as a primary route except for the short segment between SR 169 and its eastern terminus, which is secondary.
State Route 61 is a west-to-east highway in the U.S. state of Tennessee that is 81.67-mile-long (131.44 km). State Route 61 begins in Roane County, and it ends in Grainger County.
State Route 71 is a north–south state highway in Tennessee. For most of the length it is a "hidden" route, as it coincides with US 441 in all but a short section in Knoxville. The road begins at the North Carolina state line in Sevier County within the Great Smoky Mountains National Park at Newfound Gap and ends at an intersection with US 25W, SR 116, and SR 9 (hidden) in Rocky Top. Along its length SR 71 passes through Sevier County, a small portion of Blount County, Knox County, Anderson County, and in and out of Campbell County. Despite being signed on Hall of Fame Parkway in Knoxville, Tennessee, the Knox County TDOT map ignores SR 71 while SR 33 has a concurrency with US 441.
U.S. Route 27 (US 27) in Tennessee runs from the Georgia state line in Chattanooga to the Kentucky state line in Isham. It forms the informal border between the Eastern and Central timezones of the state. It stays, however, in the Eastern Time Zone.
In Tennessee, U.S. Route 412 stretches for 181.93 miles (292.79 km) through the farmland of West Tennessee and the hills of Middle Tennessee, starting at the Missouri state line near Dyersburg and running to an interchange between I-65 and SR 99 in Columbia.
U.S. Route 441 (US 441) stretches for 83.28 miles (134.03 km) through the mountains of East Tennessee, connecting Rocky Top with Knoxville, Sevierville, Gatlinburg, and the Great Smoky Mountains National Park, crossing into North Carolina at Newfound Gap. Near its northern terminus, US 441 crosses over Norris Dam and passes through Norris Dam State Park.
U.S. Route 127 in Tennessee is a 129.5-mile-long (208.4 km) United States Numbered Highway from Chattanooga to the Kentucky state line at Static. The highways connects through Dunlap, Pikeville, Crossville, and Jamestown. Throughout its length, US 127 straddles the line between East Tennessee and Middle Tennessee.
State Route 60 is a north-south major state route in East Tennessee. It covers 54 miles (87 km) and runs from the Tennessee-Georgia state line in Bradley County to Dayton joining US 27.
State Route 33 is a primary and secondary route in East Tennessee. It runs 176 miles, from the Georgia state line in Polk County, northeast to the Virginia state line north of Kyles Ford in Hancock County. South of Maryville, SR 33 is a "hidden" route which shares a concurrency with US 411.
State Route 32 is a state highway in East Tennessee. For most of its route, it is an unsigned companion route concurrent with U.S. Route 25E. The highway stretches 89 miles from the North Carolina state line to the Tennessee-Kentucky state line near the town of Cumberland Gap.
State Route 28 is a state highway in the state of Tennessee, traversing the state in a north–south axis from south of Jasper to the Kentucky state line at Static.
State Route 174 (SR 174) is a secondary east–west state highway in northern Middle Tennessee. It traverses northern Davidson and much of Sumner counties.
US 11 / US 70 in Farragut 
SR 31 in Treadway 
