U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama, to US 25W/US 70 in Newport, Tennessee. US 411 travels through northeastern Alabama, northwestern Georgia, and southeastern Tennessee. It is signed north-south, as with most highways that have odd numbers, but the route runs primarily in a northeast-southwest direction, and covers a more east-west mileage than it does north-south. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Maryville, Tennessee; Sevierville, Tennessee, and Newport, Tennessee.
U.S. Route 70N is a northern alternate to U.S. Route 70, passing through parts of Middle Tennessee and East Tennessee. It runs 86.0 miles (138.4 km) east–west from Lebanon to Crossville, connecting the cities of Carthage, Baxter, Cookeville, and Monterey.
State Route 66 is a state-maintained highway in eastern Tennessee, including a six-lane divided highway known as Winfield Dunn Parkway in Sevier County, a four-lane expressway in Hamblen and Jefferson counties and a two-lane rural collector through mountainous terrain continuing to the northeast terminus in Hancock County.
State Route 14 is a south–north route from the Mississippi border in Memphis, Tennessee to an intersection with State Route 54 in Tipton County.
State Route 160 is a state highway in East Tennessee that has both four-lane expressway and two-lane rural collector sections. It serves as a arterial bypass route of US 11E/SR 34 in the city of Morristown in Hamblen County.
In Tennessee, U.S. Route 412 stretches for 181.93 miles (292.79 km) through the farmland of West Tennessee and the hills of Middle Tennessee, starting at the Missouri state line near Dyersburg and running to an interchange between I-65 and SR 99 in Columbia.
U.S. Route 129 is a north–south United States highway that runs for 52.8 miles (85.0 km) in East Tennessee, from the North Carolina state line, near Tapoco, to Knoxville. In Tennessee, the highway is completely overlapped by unsigned State Route 115. In the Greater Knoxville area, US 129 serves as a six-lane controlled-access highway known as Alcoa Highway.
State Route 70 is a state-maintained highway in East Tennessee, beginning at the border with North Carolina in the midst of the Cherokee National Forest and the Great Smoky Mountains and ending at the Virginia border in the extremely rural and mountainous terrain of Hancock County.
State Route 107 is a 78.77-mile (126.77 km) state highway in eastern Tennessee, United States. It begins at an intersection with Round Mountain Road south of Del Rio and ends at the North Carolina state line east of Unicoi, where it becomes NC 226.
U.S. Route 127 in Tennessee is a 129.5-mile-long (208.4 km) United States Numbered Highway from Chattanooga to the Kentucky state line at Static. The highways connects through Dunlap, Pikeville, Crossville, and Jamestown. Throughout its length, US 127 straddles the line between East Tennessee and Middle Tennessee.
State Route 49 is a state highway in Tennessee. The route forms a broad southern arc that passes through the rural Middle Tennessee towns of Dover, Erin, Charlotte, Ashland City, Pleasant View, and Springfield.
State Route 351 is a state highway in Greene County, Tennessee. It begins at State Routes 70 and 107 in southern Greene County and ends at State Route 93 in northern Greene County. It forms a half loop around Greeneville and Tusculum.
State Route 32 is a state highway in East Tennessee. For most of its route, it is an unsigned companion route concurrent with U.S. Route 25E. The highway stretches 89 miles from the North Carolina state line to the Tennessee-Kentucky state line near the town of Cumberland Gap.
State Route 113 is a north–south state highway in East Tennessee.
State Route 344 is a state highway in Hamblen and Hawkins counties, within the U.S. state of Tennessee. It connects US 11E in Russellville to US 11W west of Rogersville, Tennessee via SR 113.
U.S. Route 231 in Tennessee runs north–south for 121.15 miles (194.97 km), entirely in Middle Tennessee, that starts south of Fayetteville at the Alabama state line, and ends north of Westmoreland at the Kentucky state line. For the majority of its length, between the Alabama state line and Trousdale County, it is concurrent with unsigned State Route 10.
State Route 35 is a north–south state highway in East Tennessee. The 81.35 miles (130.92 km) long state highway traverses Blount, Sevier, a small portion of Jefferson, Cocke, and Greene Counties. Most of the route is a secret, or hidden designation, as it runs concurrently with U.S. Highways in the area.
State Route 339 is a 23.1 miles (37.2 km) long east-west state highway in the mountains of East Tennessee, connecting Cherokee Hills with Cosby. For the majority of its length, SR 339 is known as Jones Cove Road, but other short sections are known as Long Springs Road and Old Newport Highway.
State Route 363, also known as Indian Creek Road, is a 6.0-mile-long (9.7 km) east-west mile long state highway in Jefferson County, Tennessee. It provides access to lakeside homes and marinas along the south shore of Douglas Lake.
State Route 438 is a 41.0 miles (66.0 km) long east-west state highway in extreme western Middle Tennessee.
US 25 / US 70 near Del Rio 
I-81 near Morristown 
SR 113 near Morristown
