Thymoquinone

Last updated
Thymoquinone
Thymoquinone.svg
Names
Preferred IUPAC name
2-Methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione
Other names
Thymoquinone
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.007.020 OOjs UI icon edit-ltr-progressive.svg
PubChem CID
UNII
  • InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3 Yes check.svgY
    Key: KEQHJBNSCLWCAE-UHFFFAOYSA-N Yes check.svgY
  • CC1=CC(=O)C(=CC1=O)C(C)C
Properties
C10H12O2
Molar mass 164.204 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Thymoquinone is a phytochemical compound found in the plant Nigella sativa . It is also found in select cultivated Monarda fistulosa plants which can be steam distilled to produce an essential oil.

It has been classified as a pan-assay interference compound, which binds indiscriminately to many proteins. [1] It is under preliminary research to identify its possible biological properties. [2] [3] [4]

See also

References

  1. ↑ Baell JB (March 2016). "Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)". Journal of Natural Products. 79 (3): 616–28. doi:10.1021/acs.jnatprod.5b00947. PMID   26900761.
  2. ↑ Farkhondeh T, Samarghandian S, Borji A (September 2017). "An overview on cardioprotective and anti-diabetic effects of thymoquinone". Asian Pacific Journal of Tropical Medicine. 10 (9): 849–854. doi: 10.1016/j.apjtm.2017.08.020 . PMID   29080612.
  3. ↑ Ali, Md Yousuf; Akter, Zakia; Mei, Zhiqiang; et al. (February 2021). "Thymoquinone in autoimmune diseases: Therapeutic potential and molecular mechanisms". Biomedicine & Pharmacotherapy. 134 111157. doi: 10.1016/j.biopha.2020.111157 . ISSN   1950-6007. PMID   33370631. S2CID   229714190.
  4. ↑ Abdelrahim, Maen; Esmail, Abdullah; Al Saadi, Noor; Zsigmond, Eva; Al Najjar, Ebtesam; Bugazia, Doaa; Al-Rawi, Hadeel; Alsaadi, Ayat; Kaseb, Ahmed O. (5 April 2022). "Thymoquinone's Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge". Frontiers in Pharmacology. 13. doi: 10.3389/fphar.2022.848676 . PMC   9022724 . PMID   35462919.
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