Transcription factor DP

Last updated
DP
PDB 2aze EBI.jpg
structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer
Identifiers
SymbolDP
Pfam PF08781
InterPro IPR014889
PROSITE PDOC00359
MEROPS S9
SCOP2 1c5e / SCOPe / SUPFAM
CAZy GT1
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

In molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors. DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [1] and negatively regulates the G1-S transition.

See also

References

  1. ↑ Rubin SM, Gall AL, Zheng N, Pavletich NP (December 2005). "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release". Cell. 123 (6): 1093–106. doi: 10.1016/j.cell.2005.09.044 . PMID   16360038. S2CID   6158027.
This article incorporates text from the public domain Pfam and InterPro: IPR014889
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.