Transmembrane Protein 205 (TMEM205) is a protein encoded on chromosome 19 by the TMEM205 gene.
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| Aliases | TMEM205 , UNQ501, transmembrane protein 205 | ||||||||||||||||||||||||
| External IDs | OMIM: 613771 MGI: 3045495 HomoloGene: 43895 GeneCards: TMEM205 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 19: 11.34 – 11.35 Mb | Chr 9: 21.92 – 21.93 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
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TMEM205 is located on the minus strand of chromosome 19 from base pair 11,453,452 to 11,456,981. In close proximity to TMEM205, CCDC159 is located slightly upstream and RAB3D slightly down stream of the genomic sequence.
TMEM205 has no known Paralogs in the Human genome. Using UCSC genome browser BLAT [5] against the human protein sequence it was found that the closest relative to humans to contain a paralog of the TMEM205 gene in its genome is the Bushbaby. TMEM205 does however have a large range of ortholog sequences.
| Genus Species | Organism common name | Divergence from humans (MYA) [6] | NCBI Protein Accession | Sequence similarity [7] | Protein length |
|---|---|---|---|---|---|
| Homo sapiens [8] | Human | 0 | AAH91472.1 | 100% | 189 |
| Pan troglodytes [9] | Chimpanzee | 6.4 | XP_003316117.1 | 100% | 189 |
| Pongo pygmaeus [10] | Orangutan | 15.8 | NP 001124814.1 | 99% | 189 |
| Gorilla gorilla [11] | Gorilla | 8.8 | XP_004060075.1 | 99% | 189 |
| Callithrix jacchus [12] | Common Marmoset | 43.9 | XP_002761800.1 | 96% | 189 |
| Mus musculus [13] | Mouse | 94.1 | BAA92792764.1 | 88% | 189 |
| Sarcophilus harrisii [14] | Tasmanian Devil | 162.6 | XP_003760487.1 | 77% | 193 |
| Crotalus adamanteus [15] | Rattle Snake | 296 | AFJ51753.1 | 85% | 188 |
| Xenopus [16] | Xenopus | 371 | NP_001037942.1 | 68% | 189 |
The human homologue of TMEM205 is 189 amino acids long and has a molecular weight of 21.2 kDa. It contains 4 hydrophobic helical domains that are predicted to be transmembrane domains.
TMEM205 has been shown to be expressed in greater amounts in tissues that have secretory function. These tissues include the thyroid, adrenal gland, pancrease, and mammary tissues. [17] The protein has also been shown to have increased expression in tumor tissue that have become resistant to platinum based chemotherapy drugs.
TMEM205 is thought to be a multi-pass transmembrane protein. It has been shown to be located at the plasma membrane in humans tissues and translocates to the nuclear envelope when cells become resistant to Cisplatin. [17] It contains four domains predicted to be trans membrane domains by TMHMM analysis.
TMEM205 has been shown to be co-located with RAB8 a known GTPase involved in vesicular traffic. [18]
TMEM205 has been shown to be involved in Cisplatin resistance. Cisplatin is a chemotherapeutic drug that is commonly used to treat solid malignancies such as carcinomas, sarcomas, and lymphomas. In addition to being involved in Cisplatin resistance there is growing evidence that the protein is also involved in the diseases thyroiditis and prostatitis
Transmembrane protein 50A is a protein that in humans is encoded by the TMEM50A gene.
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TMEM106A is a gene that encodes the transmembrane protein 106A (TMEM106A) in Homo sapiens. It is located at 17q21.31 on the plus strand next to cancer-related genes NBR1 and BRCA1. The TMEM106A gene contains a domain of unknown function, DUF1356.
Protein FAM83A also known as tumor antigen BJ-TSA-9 is a protein that in humans is encoded by the FAM83A gene.
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Transmembrane protein 131-like, alternatively named uncharacterized protein KIAA0922, is an integral transmembrane protein encoded by the human gene KIAA0922 that is significantly conserved in eukaryotes, at least through protists. Although the function of this gene is not yet fully elucidated, initial microarray evidence suggests that it may be involved in immune responses. Furthermore, its paralog, prolyl endopeptidase (PREP) whose function is known, provides clues as to the function of TMEM131L.
RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the RUFY2 gene. The RUFY2 gene is named for two of its domains, the RUN domain and FYVE domains. RUFY2 is a member of the RUFY family of proteins that include RUFY1, RUFY2, RUFY3, and RUFY4. RUFY2 protein has a dynamic role in endosomal membrane trafficking.
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Transmembrane protein 268 is a protein that in humans is encoded by TMEM268 gene. The protein is a transmembrane protein of 342 amino acids long with eight alternative splice variants. The protein has been identified in organisms from the common fruit fly to primates. To date, there has been no protein expression found in organisms simpler than insects.
TMEM156 is a gene that encodes the transmembrane protein 156 (TMEM156) in Homo sapiens. It has the clone name of FLJ23235.
Transmembrane Protein 176B, or TMEM176B is a transmembrane protein that in humans is encoded by the TMEM176B gene. It is thought to play a role in the process of maturation of dendritic cells.
Transmembrane protein 255A is a protein that is encoded by the TMEM255A gene. TMEM255A is often referred to as family with sequence similarity 70, member A (FAM70A). The TMEM255A protein is transmembrane and is predicted to be located the nuclear envelope of eukaryote organisms.
Transmembrane Protein 217 is a protein encoded by the gene TMEM217. TMEM217 has been found to have expression correlated with the lymphatic system and endothelial tissues and has been predicted to have a function linked to the cytoskeleton.
Transmembrane protein 171 (TMEM171) is a protein that in humans is encoded by the TMEM171 gene.
Transmembrane protein 179 is a protein that in humans is encoded by the TMEM179 gene. The function of transmembrane protein 179 is not yet well understood, but it is believed to have a function in the nervous system.
Transmembrane Protein 81 or TMEM81 is a protein that in humans is encoded by the TMEM81 gene. TMEM81 is a poorly-characterized transmembrane protein which contains an extracellular immunoglobulin domain.
TMEM275 is a protein that in humans is encoded by the TMEM275 gene. TMEM275 has two, highly-conserved, helical trans-membrane regions. It is predicted to reside within the plasma membrane or the endoplasmic reticulum's membrane.
