Transportin-3

TNPO3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C0O, 4C0P, 4C0Q, 4OL0
Identifiers
Aliases	TNPO3 , IPO12, LGMD1F, MTR10A, TRN-SR, TRN-SR2, TRNSR, transportin 3, LGMDD2
External IDs	OMIM: 610032 MGI: 1196412 HomoloGene: 40848 GeneCards: TNPO3
Gene location (Human)
Chr.	Chromosome 7 (human)
End	129,055,173 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	29,609,886 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; internal globus pallidus; ; external globus pallidus; ; olfactory bulb; ; cardia; ; inferior olivary nucleus; ; cancellous bone; ; pylorus; ; embryo; ; ganglionic eminence;
	Top expressed in
	maxillary prominence; ; spermatocyte; ; renal corpuscle; ; medullary collecting duct; ; primitive streak; ; internal carotid artery; ; external carotid artery; ; yolk sac; ; lacrimal gland; ; subiculum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nuclear localization sequence binding ; protein binding ; identical protein binding ; signaling receptor activity ; nuclear import signal receptor activity ;
Cellular component	cytoplasm ; nuclear membrane ; intracellular membrane-bounded organelle ; nucleus ;
Biological process	protein transport ; signal transduction ; protein import into nucleus ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	23534
	320938
	ENSG00000064419
	ENSMUSG00000012535
	Q9Y5L0
	Q6P2B1
	NM_001191028 ; NM_012470
	NM_177296 ; NM_001347079 ; NM_001361290
NP_001177957 ; NP_036602 ; NP_001369145 ; NP_001369146 ; NP_001369147 ;
	NP_001369148 ; NP_001369149 ; NP_001369150 ; NP_001369151 ; NP_001369152 ; NP_036602.1 Contents Function ; Clinical significance ; References ; Further reading ;
	NP_001334008 ; NP_796270 ; NP_001348219
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.^[5]^[6]^[7]

Function

TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors.^[5]^[7]

Clinical significance

The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis.^[8]

Related Research Articles

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (SFRS10), is a protein that in humans is encoded by the TRA2B gene.

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.

Importin-7 is a protein that in humans is encoded by the IPO7 gene.

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.

Splicing factor, arginine/serine-rich 16 is a protein that in humans is encoded by the SFRS16 gene.

Coiled-coil domain-containing protein 55 is a protein that in humans is encoded by the CCDC55 gene. It is now known as nuclear speckle splicing regulatory protein 1. The HGNC approved gene name is NSRP1.

Peptidyl-prolyl cis-trans isomerase G is an enzyme that in humans is encoded by the PPIG gene.

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.

SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

Putative splicing factor, arginine/serine-rich 14 is a protein that in humans is encoded by the SFRS14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000064419 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000012535 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Kataoka N, Bachorik JL, Dreyfuss G (Jul 1999). "Transportin-SR, a nuclear import receptor for SR proteins". J Cell Biol. 145 (6): 1145–52. doi:10.1083/jcb.145.6.1145. PMC 2133142 . PMID 10366588.
↑ Lai MC, Lin RI, Huang SY, Tsai CW, Tarn WY (Apr 2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins". J Biol Chem. 275 (11): 7950–7. doi: 10.1074/jbc.275.11.7950 . PMID 10713112.
1 2 "Entrez Gene: TNPO3 transportin 3".
↑ Radstake TR, Gorlova O, Rueda B, et al. (May 2010). "Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus". Nat. Genet. 42 (5): 426–9. doi:10.1038/ng.565. PMC 2861917 . PMID 20383147.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lai MC, Lin RI, Tarn WY (2001). "Transportin-SR2 mediates nuclear import of phosphorylated SR proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10154–9. doi: 10.1073/pnas.181354098 . PMC 56931 . PMID 11517331.
Allemand E, Dokudovskaya S, Bordonné R, Tazi J (2003). "A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1". Mol. Biol. Cell. 13 (7): 2436–47. doi:10.1091/mbc.E02-02-0102. PMC 117325 . PMID 12134081.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi: 10.1016/j.ygeno.2006.04.003 . PMID 16730941.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000064419 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000012535 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10366588-5] 1 2 Kataoka N, Bachorik JL, Dreyfuss G (Jul 1999). "Transportin-SR, a nuclear import receptor for SR proteins". J Cell Biol. 145 (6): 1145–52. doi:10.1083/jcb.145.6.1145. PMC 2133142 . PMID 10366588.

[pmid10713112-6] Lai MC, Lin RI, Huang SY, Tsai CW, Tarn WY (Apr 2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins". J Biol Chem. 275 (11): 7950–7. doi: 10.1074/jbc.275.11.7950 . PMID 10713112.

[entrez-7] 1 2 "Entrez Gene: TNPO3 transportin 3".

[pmid20383147-8] Radstake TR, Gorlova O, Rueda B, et al. (May 2010). "Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus". Nat. Genet. 42 (5): 426–9. doi:10.1038/ng.565. PMC 2861917 . PMID 20383147.

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Transportin-3

Contents

Function

Clinical significance

Related Research Articles

References

Further reading