Trypanosoma rangeli

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Trypanosoma rangeli
Scientific classification
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T. rangeli
Binomial name
Trypanosoma rangeli
Tejera, 1920

Trypanosoma rangeli is a species of hemoflagellate excavate parasites of the genus Trypanosoma. Although infecting a variety of mammalian species in a wide geographical area in Central and South America, this parasite is considered non-pathogenic to these hosts. T. rangeli is transmitted by bite of infected triatomine bugs of the Reduviidae family, commonly known as barbeiro, winchuka [1] (vinchuca), chinche, pito ou chupão. [2]

The genome was published in September 2014. [3]

Occurring in sympatry with Trypanosoma cruzi , the etiological agent of Chagas disease, in wide geographical areas in the Americas, T. rangeli shares hosts, vectors and a large amount of its antigenic coat T. cruzi leading to misdiagnosis of Chagas disease. [4] [5]

Related Research Articles

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<i>Leishmania</i> Genus of parasitic flagellate protist in the Kinetoplastea class

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Tsetse fly

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<i>Trypanosoma</i> Genus of parasitic flagellate protist in the Kinetoplastea class

Trypanosoma is a genus of kinetoplastids, a monophyletic group of unicellular parasitic flagellate protozoa. Trypanosoma is part of the phylum Sarcomastigophora. The name is derived from the Greek trypano- (borer) and soma (body) because of their corkscrew-like motion. Most trypanosomes are heteroxenous and most are transmitted via a vector. The majority of species are transmitted by blood-feeding invertebrates, but there are different mechanisms among the varying species. Some, such as Trypanosoma equiperdum, are spread by direct contact. In an invertebrate host they are generally found in the intestine, but normally occupy the bloodstream or an intracellular environment in the mammalian host.

Carlos Chagas

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Triatominae

The members of the Triatominae, a subfamily of the Reduviidae, are also known as conenose bugs, kissing bugs, or vampire bugs. Other local names for them used in Latin America include barbeiros, vinchucas, pitos, chipos and chinches. Most of the 130 or more species of this subfamily feed on vertebrate blood; a very few species feed on other invertebrates. They are mainly found and widespread in the Americas, with a few species present in Asia, Africa, and Australia. These bugs usually share shelter with nesting vertebrates, from which they suck blood. In areas where Chagas disease occurs, all triatomine species are potential vectors of the Chagas disease parasite Trypanosoma cruzi, but only those species that are well adapted to living with humans are considered important vectors. Proteins released from their bites have been known to induce anaphylaxis in sensitive and sensitized individuals.

<i>Triatoma</i>

Triatoma is a genus of assassin bug in the subfamily Triatominae. The members of Triatoma are blood-sucking insects that can transmit serious diseases, such as Chagas disease. Their saliva may also trigger allergic reactions in sensitive individuals, up to and including severe anaphylactic shock.

<i>Rhodnius</i>

Rhodnius is a genus of assassin bugs in the subfamily Triatominae, and is an important vector in the spread of Chagas disease. The Rhodnius species were important models for Sir Vincent Wigglesworth's studies of insect physiology, specifically growth and development.

Dipetalogaster, a genus of Triatominae, the kissing bugs, has only a single species, Dipetalogaster maxima, which is found in the Mexican state of Baja California Sur. Originally the blood-sucking Dipetalogaster lived in crevices in rocks where it typically fed on lizards, but following human growth in its range it now also commonly feeds on humans and domestic animals.

Panstrongylus geniculatus

Panstrogylus geniculatus is a blood-sucking sylvatic insect noted as a putative vector of minor importance in the transmission of Trypanosoma cruzi to humans; this is a parasite, which causes Chagas disease. The insect is described as sylvatic; subsisting primarily in humid forests, and is also known to inhabit vertebrate nesting places such as those of the armadillo, and is also involved in enzootic transmission of T. cruzi to those species. It has wide distribution throughout 16 Latin American countries.

<i>Trypanosoma cruzi</i> Species of parasitic euglenoids (protozoans)

Trypanosoma cruzi is a species of parasitic euglenoids. Amongst the protozoa, the trypanosomes characteristically bore tissue in another organism and feed on blood (primarily) and also lymph. This behaviour causes disease or the likelihood of disease that varies with the organism: Chagas disease in humans, dourine and surra in horses, and a brucellosis-like disease in cattle. Parasites need a host body and the haematophagous insect triatomine is the major vector in accord with a mechanism of infection. The triatomine likes the nests of vertebrate animals for shelter, where it bites and sucks blood for food. Individual triatomines infected with protozoa from other contact with animals transmit trypanosomes when the triatomine deposits its faeces on the host's skin surface and then bites. Penetration of the infected faeces is further facilitated by the scratching of the bite area by the human or animal host.

<i>Triatoma nigromaculata</i>

Triatoma nigromaculata is a sylvatic species of insect usually found in hollow trees, in vertebrate nests on trees and occasionally in human dwellings. It usually lives in relatively humid forests at high altitudes on mountain regions and foot hills. As all members of the subfamily Triatominae, T. nigromaculata is a blood-sucking bug and a potential vector of Chagas disease. This species is distributed mainly in Venezuela, but some specimens have also been found in Perú and Colombia (Cauca).

<i>Pneumocystis jirovecii</i>

Pneumocystis jirovecii is a yeast-like fungus of the genus Pneumocystis. The causative organism of Pneumocystis pneumonia, it is an important human pathogen, particularly among immunocompromised hosts. Prior to its discovery as a human-specific pathogen, P. jirovecii was known as P. carinii.

Nifurtimox

Nifurtimox, sold under the brand name Lampit, is a medication used to treat Chagas disease and sleeping sickness. For sleeping sickness it is used together with eflornithine in nifurtimox-eflornithine combination treatment. In Chagas disease it is a second-line option to benznidazole. It is given by mouth.

Triatoma brasiliensis

Triatoma brasiliensis Neiva, 1911 is now considered the most important Chagas disease vector in the semiarid areas of northeastern Brazil. T. brasiliensis occurs in 12 Brazilian states, including Maranhão, Piauí, Ceará, Rio Grande do Norte, and Paraíba. T. brasiliensis is native to this part of Brazil, and thus persists in the natural environment. This species of Kissing Bug has the greatest potential to spread Chaga's disease due to its distribution over large areas where numerous people reside. Triatoma species are commonly called Kissing Bugs because they bite around the mouth where skin is thinner. T. brasiliensis also has the greatest potential to colonize new areas and spread throughout northeastern parts of Brazil. This makes control problematic.

<i>Triatoma rubrovaria</i>

Triatoma rubrovaria is an insect which is ubiquitous in Uruguay, in neighboring parts of northeastern Argentina, and in the southern states of Paraná and Rio Grande do Sul in Brazil. This species of triatomine is found mainly among exfoliate rocks known as pedregales. It was earlier reported as T. (triatoma) rubrovaria, a sylvatic species inhabiting rock piles, rarely found in human dwellings. This species may be a highly competent vector of Trypanosoma cruzi, the causative agent of Chagas disease. In Rio Grande do Sul, data from the Chagas disease Control Program have indicated an increasing of domiciliary and peridomiciliary invasion of T. rubrovaria, where it has become the most frequently triatomine species captured in that State since the control of T. infestans.

Cruzipain is a cysteine protease expressed by Trypanosoma cruzi.

<i>Trypanosoma lewisi</i>

Trypanosoma lewisi is a globally distributed parasite of Rattus species and other rodents such as mice, and of kangaroo rats in America. Among these host species were two endemic species of rats: Rattus macleari and Rattus nativitatis. Both are now believed to be extinct. It is not very clear whether or not the same parasite infected both species. However, both parasites are very similar. The northern rat flea, Nosopsyllus fasciatus acts as the vector for the parasite, harboring the epimastigote stage in its midgut. The trypomastigote is the stage that is present in the main host, the rodent. The epimastigote form attaches itself to the rectum of the insect using its flagella to burrow through the rectal walls. The parasites also appear in the flea's feces. Ingestion of either the flea or its feces during grooming infects the host rodent with the parasites. T. lewisi is normally non-pathogenic but is known to have produced fatal infections in rats.

Triatoma indictiva is an arthropod in the assassin bug family of Reduviidae, and is an important vector of Trypanosoma cruzi. T. cruzi is the protozoan that causes Chagas Disease, which affects approximately eight million people a year in the western hemisphere alone. Triatoma indictiva is found in Mexico and throughout the southern United States, including Arizona and Texas.

References

  1. Teofilo Laime Ajacopa, Diccionario Bilingüe Iskay simipi yuyayk'ancha, La Paz, 2007 (Quechua-Spanish dictionary)
  2. de Moraes MH, Guarneri AA, Girardi FP, et al. (2008). "Different serological cross-reactivity of Trypanosoma rangeli forms in Trypanosoma cruzi-infected patients sera". Parasit Vectors. 1 (1): 20. doi:10.1186/1756-3305-1-20. PMC   2475519 . PMID   18611261.
  3. Stoco PH, et al. (Sep 2014). "Genome of the avirulent human-infective trypanosome--Trypanosoma rangeli". PLoS Negl Trop Dis. 8 (9): e3176. doi:10.1371/journal.pntd.0003176. PMC   4169256 . PMID   25233456.
  4. Basso B, Castro I, Introini V, Gil P, Truyens C, Moretti E (May 2007). "Vaccination with Trypanosoma rangeli reduces the infectiousness of dogs experimentally infected with Trypanosoma cruzi". Vaccine. 25 (19): 3855–8. doi:10.1016/j.vaccine.2007.01.114. PMC   7127752 . PMID   17349724.
  5. Basso B, Moretti E, Fretes R (June 2008). "Vaccination with epimastigotes of different strains of Trypanosoma rangeli protects mice against Trypanosoma cruzi infection". Mem. Inst. Oswaldo Cruz. 103 (4): 370–4. doi: 10.1590/S0074-02762008000400010 . PMID   18660992.

Bibliography