Tsukamurella pulmonis

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Tsukamurella pulmonis
Scientific classification
Domain:
Phylum:
Class:
Order:
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Genus:
Species:
T. pulmonis
Binomial name
Tsukamurella pulmonis
Yassin et al. 1996 [1]
Type strain
ATCC 700081, CCUG 35732, CIP 104791, DSM 44142, IFM 809, IMMIB D-1321, JCM 10111, KCTC 9963, PCM 2578 [2]

Tsukamurella pulmonis is a Gram-positive and aerobic bacterium from the genus of Tsukamurella which has been isolated from the sputum from a patient with lung tuberculosis in Germany. [1] [3] [4] [5] [6]

Contents

Characteristic as secondary metabolites production inducer by actinomycetes

Tsukamurella pulmonis TP-B0596 induced production of anti-fungal 5aTHQs (5-Alkyl-1,2,3,4-tetrahydroquinolines) [7] and anti-bacterial Streptoaminals (lipidic [5,5]-Spirohemiaminals) [8] by Streptomyces sp. HEK616. T. pulmonis TP-B0596 was also shown to induce production of secondary metabolites; dracolactams by Micromonospora sp. HEK797, [9] niizalactams by Streptomyces sp. NZ-6, [10] chojalactones by Streptomyces sp. CJ-5, [11] and Alchivemycin A by Streptomyces sp. S-522. [12]

Related Research Articles

Antimycins are produced as secondary metabolites by Streptomyces bacteria, a soil bacteria. These specialized metabolites likely function to kill neighboring organisms in order to provide the streptomyces bacteria with a competitive edge.

Benzyl group

In organic chemistry, benzyl is the substituent or molecular fragment possessing the structure C6H5CH2–. Benzyl features a benzene ring attached to a CH2 group.

Ionomycin Chemical compound

Ionomycin is an ionophore and an antibiotic that binds calcium ions (Ca2+) in a ratio 1:1. It is produced by the bacterium Streptomyces conglobatus. It binds also other divalent cations like magnesium and cadmium, but binds Ca2+ preferably.

Benzothiophene aromatic organic compound

Benzothiophene is an aromatic organic compound with a molecular formula C8H6S and an odor similar to naphthalene (mothballs). It occurs naturally as a constituent of petroleum-related deposits such as lignite tar. Benzothiophene has no household use. In addition to benzo[b]thiophene, a second isomer is known: benzo[c]thiophene.

Lysergol Chemical compound

Lysergol is an alkaloid of the ergoline family that occurs as a minor constituent in some species of fungi, and in the morning glory family of plants (Convolvulaceae), including the hallucinogenic seeds of Rivea corymbosa (ololiuhqui), Argyreia nervosa and Ipomoea violacea. Lysergol is not a controlled substance in the USA. Its possession and sale is also legal under the U.S. Federal Analog Act because it does not have a known pharmacological action or a precursor relationship to LSD, which is a controlled substance. However, lysergol is an intermediate in the manufacture of some ergoloid medicines.

Carbonyl iron is a highly pure iron, prepared by chemical decomposition of purified iron pentacarbonyl. It usually has the appearance of grey powder, composed of spherical microparticles. Most of the impurities are carbon, oxygen, and nitrogen.

Tetrahydrothiophene is an organosulfur compound with the formula (CH2)4S. It contains a five-membered ring consisting of four carbon atoms and a sulfur atom. It is the saturated analog of thiophene. It is a volatile, colorless liquid with an intensely unpleasant odor. It is also known as thiophane, thiolane, or THT.

Oxidative decarboxylation reactions are oxidation reactions in which a carboxylate group is removed, forming carbon dioxide. They often occur in biological systems: there are many examples in the citric acid cycle. This type of reaction probably started early at the origin of life.

2-Methyl-2-nitrosopropane (MNP or t-nitrosobutane) is the organic compound with the formula (CH3)3CNO. It is a blue liquid that is used in chemical research as a spin trap, i.e. it binds to radicals.

The aminocyclitols are compounds related to cyclitols. They possess features of relative and absolute configuration that are characteristic of their class and have been extensively studied; but these features are not clearly displayed by general methods of stereochemical nomenclature, so that special methods of specifying their configuration are justified and have long been used. In other than stereochemical respects, their nomenclature should follow the general rules of organic chemistry.

Liebeskind–Srogl coupling

The Liebeskind–Srogl coupling reaction is an organic reaction forming a new carbon–carbon bond from a thioester and a boronic acid using a metal catalyst. It is a cross-coupling reaction. This reaction was invented by and named after Jiri Srogl from the Academy of Sciences, Czech Republic, and Lanny S. Liebeskind from Emory University, Atlanta, Georgia, USA. There are three generations of this reaction, with the first generation shown below. The original transformation used catalytic Pd(0), TFP = tris(2-furyl)phosphine as an additional ligand and stoichiometric CuTC = copper(I) thiophene-2-carboxylate as a co-metal catalyst. The overall reaction scheme is shown below.

The Center for Pharmaceutical Research and Innovation (CPRI) is a University of Kentucky-based research center established by the University of Kentucky College of Pharmacy in 2012 to facilitate academic translational research and drug discovery/drug development. The UK CPRI specializes in natural product-based drug discovery from microbes found within unique environments including underground and surface coal mines, acid mine drainage and mine reclamation sites, thermal vents associated with underground coal mine fires and deep-well drilling for carbon sequestration. CPRI also provides core support for medicinal chemistry, assay development and screening, rational drug design, computational chemistry, and ADMET. The Center collaborates with investigators focused on drug discovery or development research in the areas of cancer, drug and alcohol addiction, cardiovascular disease, infectious disease, regenerative medicine and neurodegenerative disease.

Streptomyces cinnamoneus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. Streptomyces cinnamoneus produces duramycin A, duramycin B, duramycin C, carbomycin, cinnomycin and fungichromin.

Streptomyces leeuwenhoekii is a bacterium species from the genus of Streptomyces which has been isolated from hyper-arid desert soil from Salar de Atacama in Chile. Streptomyces leeuwenhoekii produces chaxalactins and chaxamycins.

Streptomyces nigrescens is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces nigrescens produces 5-alkyl-1,2,3,4-tetrahydroquinolines and the antibiotics phoslactomycin A - F.

Streptomyces spinoverrucosus is a bacterium species from the genus of Streptomyces which has been isolated from air in Kuwait. Streptomyces spinoverrucosus produces salinazinone A, salinazinone B, galvaquinone A, galvaquinone B, galvaquinone C, spithioneine A, spithioneine B and anthraquinones.

Tris(2,2,2-trifluoroethyl) borate Chemical compound

Tris(2,2,2-trifluoroethyl) borate, also commonly referred to as the Sheppard amidation reagent, is a chemical compound with the formula B(OCH2CF3)3. This borate ester reagent is used in organic synthesis.

Peter J. H. Scott

Peter J. H. Scott FRSC CChem is a British and American chemist and radiochemist who is an Associate Professor of Radiology and Pharmacology, as well as a Faculty Scientist in the Interdepartmental Program in Medicinal Chemistry and a Core Member of the Rogel Cancer Center at the University of Michigan in the United States. He is director of the University of Michigan Positron Emission Tomography (PET) Center, and runs a research group developing new radiochemistry methodology and novel PET radiotracers.

Empowering Women in Organic Chemistry (EWOC) hosts an annual meeting of women who work or plan to work in the field of Organic Chemistry broadly defined, from all types of institutions. EWOC seeks to empower all marginalized individuals by promoting equity, justice, diversity, and inclusion across all chemistry fields. The first meeting was held on June 28, 2019 at the University of Pennsylvania. The meeting consists of both science and career topics to provide support and guidance for the next generation of women chemists, as well as provide opportunities for professionals to learn up-to-date science, network and share experiences. The 2020 meeting was held virtually on Thursday, August 13 and Friday, August 14.

Tetrahydroxanthone

Tetrahydroxanthones are natural products formally derived by partial reduction of xanthone. They are produced by various fungi, bacteria, and plants. Some are precursors to larger xanthone natural products. One example is neosartorin, composed of 5-acetylblennolide A and blennolide C, exhibits antibacterial activity against Gram-positive bacteria, notably including Staphylococcus aureus.

References

  1. 1 2 Parte, A.C. "Tsukamurella". LPSN .
  2. "Tsukamurella pulmonis Taxon Passport - StrainInfo". www.straininfo.net.
  3. YASSIN, A. F.; RAINEY, F. A.; BRZEZINKA, H.; BURGHARDT, J.; RIFAI, M.; SEIFERT, P.; FELDMANN, K.; SCHAAL, K. P. (1 April 1996). "Tsukamurella pulmonis sp. nov". International Journal of Systematic Bacteriology. 46 (2): 429–436. doi: 10.1099/00207713-46-2-429 . PMID   8934902.
  4. "Tsukamurella pulmonis". www.uniprot.org.
  5. "Details: DSM-44142". www.dsmz.de.
  6. Stephen, Dr. Berger (2015). GIDEON Guide to Medically Important Bacteria. GIDEON Informatics Inc. ISBN   978-1-4988-0429-5.
  7. Sugiyama, Ryosuke; Nishimura, Shinichi; Ozaki, Taro; Asamizu, Shumpei; Onaka, Hiroyasu; Kakeya, Hideaki (17 April 2015). "5-Alkyl-1,2,3,4-tetrahydroquinolines, New Membrane-Interacting Lipophilic Metabolites Produced by Combined Culture of Streptomyces nigrescens and Tsukamurella pulmonis". Organic Letters. 17 (8): 1918–1921. doi:10.1021/acs.orglett.5b00607. PMID   25826296.
  8. Sugiyama, Ryosuke; Nishimura, Shinichi; Ozaki, Taro; Asamizu, Shumpei; Onaka, Hiroyasu; Kakeya, Hideaki (22 August 2016). "Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis". Angewandte Chemie International Edition. 55 (35): 10278–10282. doi:10.1002/anie.201604126. PMID   27459894.
  9. Hoshino, Shotaro; Okada, Masahiro; Awakawa, Takayoshi; Asamizu, Shumpei; Onaka, Hiroyasu; Abe, Ikuro (2017-09-15). "Mycolic Acid Containing Bacterium Stimulates Tandem Cyclization of Polyene Macrolactam in a Lake Sediment Derived Rare Actinomycete". Organic Letters. 19 (18): 4992–4995. doi:10.1021/acs.orglett.7b02508. ISSN   1523-7060. PMID   28880091.
  10. Hoshino, Shotaro; Okada, Masahiro; Wakimoto, Toshiyuki; Zhang, Huiping; Hayashi, Fumiaki; Onaka, Hiroyasu; Abe, Ikuro (2015-12-24). "Niizalactams A–C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium". Journal of Natural Products. 78 (12): 3011–3017. doi:10.1021/acs.jnatprod.5b00804. ISSN   0163-3864. PMID   26624939.
  11. Hoshino, Shotaro; Wakimoto, Toshiyuki; Onaka, Hiroyasu; Abe, Ikuro (2015-03-20). "Chojalactones A–C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium". Organic Letters. 17 (6): 1501–1504. doi:10.1021/acs.orglett.5b00385. ISSN   1523-7060. PMID   25742189.
  12. Igarashi, Yasuhiro; Kim, Youngju; In, Yasuko; Ishida, Toshimasa; Kan, Yukiko; Fujita, Tsuyoshi; Iwashita, Takashi; Tabata, Hirokazu; Onaka, Hiroyasu (2010-08-06). "Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp". Organic Letters. 12 (15): 3402–3405. doi:10.1021/ol1012982. ISSN   1523-7060. PMID   20670006.

Further reading