Pyridinium refers to the cation [C5H5NH]+. It is the conjugate acid of pyridine. Many related cations are known involving substituted pyridines, e.g. picolines, lutidines, collidines. They are prepared by treating pyridine with acids.
Antimycins are produced as secondary metabolites by Streptomyces bacteria, a soil bacteria. These specialized metabolites likely function to kill neighboring organisms in order to provide the streptomyces bacteria with a competitive edge.
In organic chemistry, benzyl is the substituent or molecular fragment possessing the structure R−CH2−C6H5. Benzyl features a benzene ring attached to a methylene group.
Ionomycin is an ionophore and an antibiotic that binds calcium ions (Ca2+) in a ratio 1:1. It is produced by the bacterium Streptomyces conglobatus. It binds also other divalent cations like magnesium and cadmium, but binds Ca2+ preferably.
The Peterson olefination is the chemical reaction of α-silyl carbanions with ketones to form a β-hydroxysilane (2) which eliminates to form alkenes (3).
Lysergol is an alkaloid of the ergoline family that occurs as a minor constituent in some species of fungi, and in the morning glory family of plants (Convolvulaceae), including the hallucinogenic seeds of Rivea corymbosa (ololiuhqui), Argyreia nervosa and Ipomoea violacea. Lysergol is not a controlled substance in the USA. Its possession and sale is also legal under the U.S. Federal Analog Act because it does not have a known pharmacological action or a precursor relationship to LSD, which is a controlled substance. However, lysergol is an intermediate in the manufacture of some ergoloid medicines.
2-Methyl-2-nitrosopropane (MNP or t-nitrosobutane) is the organic compound with the formula (CH3)3CNO. It is a blue liquid that is used in chemical research as a spin trap, i.e. it binds to radicals.
The aminocyclitols are compounds related to cyclitols. They possess features of relative and absolute configuration that are characteristic of their class and have been extensively studied; but these features are not clearly displayed by general methods of stereochemical nomenclature, so that special methods of specifying their configuration are justified and have long been used. In other than stereochemical respects, their nomenclature should follow the general rules of organic chemistry.
The Liebeskind–Srogl coupling reaction is an organic reaction forming a new carbon–carbon bond from a thioester and a boronic acid using a metal catalyst. It is a cross-coupling reaction. This reaction was invented by and named after Jiri Srogl from the Academy of Sciences, Czech Republic, and Lanny S. Liebeskind from Emory University, Atlanta, Georgia, USA. There are three generations of this reaction, with the first generation shown below. The original transformation used catalytic Pd(0), TFP = tris(2-furyl)phosphine as an additional ligand and stoichiometric CuTC = copper(I) thiophene-2-carboxylate as a co-metal catalyst. The overall reaction scheme is shown below.
The Center for Pharmaceutical Research and Innovation (CPRI) is a University of Kentucky-based research center established by the University of Kentucky College of Pharmacy in 2012 to facilitate academic translational research and drug discovery/drug development. The UK CPRI specializes in natural product-based drug discovery from microbes found within unique environments including underground and surface coal mines, acid mine drainage and mine reclamation sites, thermal vents associated with underground coal mine fires and deep-well drilling for carbon sequestration. CPRI also provides core support for medicinal chemistry, assay development and screening, rational drug design, computational chemistry, and ADMET. The Center collaborates with investigators focused on drug discovery or development research in the areas of cancer, drug and alcohol addiction, cardiovascular disease, infectious disease, regenerative medicine and neurodegenerative disease.
Streptomyces cinnamoneus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. Streptomyces cinnamoneus produces duramycin A, duramycin B, duramycin C, carbomycin, cinnomycin and fungichromin.
Streptomyces leeuwenhoekii is a bacterium species from the genus of Streptomyces which has been isolated from hyper-arid desert soil from Salar de Atacama in Chile. Streptomyces leeuwenhoekii produces chaxalactins and chaxamycins.
Streptomyces nigrescens is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces nigrescens produces 5-alkyl-1,2,3,4-tetrahydroquinolines and the antibiotics phoslactomycin A - F.
Streptomyces spinoverrucosus is a bacterium species from the genus of Streptomyces which has been isolated from air in Kuwait. Streptomyces spinoverrucosus produces salinazinone A, salinazinone B, galvaquinone A, galvaquinone B, galvaquinone C, spithioneine A, spithioneine B and anthraquinones.
Tris(2,2,2-trifluoroethyl) borate, also commonly referred to as the Sheppard amidation reagent, is a chemical compound with the formula B(OCH2CF3)3. This borate ester reagent is used in organic synthesis.
Peter J. H. Scott FRSC CChem is a British and American chemist and radiochemist who is a professor of radiology, professor of pharmacology and professor of medicinal chemistry, as well as a core member of the Rogel Cancer Center at the University of Michigan in the United States. He is Chief of Nuclear Medicine and director of the University of Michigan Positron Emission Tomography (PET) Center, and runs a research group developing new radiochemistry methodology and novel PET radiotracers.
Lydicamycin is an organic compound with the molecular formula C47H74N4O10. Lydicamycin is an antibiotic with activity against Gram-positive bacteria. The bacteria Streptomyces lydicamycinicus and Streptomyces platensis produces lydicamycin.
Quinolidomicin A1 is a 60-membered macrocyclic compound isolated from Micromonospora sp. JY16. Quinolidomicins are a class of macrolides that contain a benzoquinone chromophore as well as an immense lactone ring, which far surpasses that in monozanomycin. It is currently the largest identified macrolide of terrestrial origin. It was initially discovered when in a screening for anti-tumor antibiotics, where it was found to be cytotoxic against P388 murine leukemia cells (IC50 8 nM), and has later been found to have strong cytotoxic activity against HT-29, MKN28, K562, and KB.
Jason Kelby Sello is an American chemist who is a professor of pharmaceutical chemistry at the University of California, San Francisco. His research looks to develop antibacterial agents and technologies for bioenergy. In 2020, he was named by Cell Press as one of 1000 inspiring Black scientists in America.
TCFH is an electrophilic amidine reagent used to activate a number of functional groups for reaction with nucleophilies. TCFH is most commonly used to activate carboxylic acids for reaction with amines in the context of amide bond formation and peptide synthesis.
