Two feet-one hand syndrome

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Two feet-one hand syndrome
Specialty Dermatology, infectious diseases
Symptoms Diffuse scaling of palms and prominent palmar creases in one hand, tinea pedis in both feet [1]
Complications Secondary bacterial infection [2]
DurationTendency to last longterm [3]
Causes Trichophyton rubrum [3]
Risk factors Excessive sweating [4]
Diagnostic method Visualization, microscopy, culture [4]
Differential diagnosis Dermatitis, psoriasis, keratoderma, hyperkeratosis, allergic contact dermatitis [5]
PreventionFoot hygiene, [4] avoid scratching feet and toes [6]
Treatment Antifungals [4]
Medication Oral terbinafine, itraconazole, fluconazole, griseofulvin [4]
FrequencyMales>females [3]

Two feet-one hand syndrome (TFOHS) is a long-term fungal condition in which athlete's foot or fungal toenail infections in both feet is associated with tinea manuum in one hand. [3] [7] Often the feet are affected for several years before a diffuse scaling rash on the palm of one hand appears, at which point some affected people may decide to seek medical help. [7]

Contents

The most common causative organism is Trichophyton rubrum . [3] The condition is more likely to occur in people who sweat more. [4] Diagnosis is by visualization, microscopy and culture. [4] It may appear similar to dermatitis, psoriasis, keratoderma, hyperkeratosis and allergic contact dermatitis. [5] Treatment is with long-term systemic antifungals, typically oral terbinafine or itraconazole. [4] [8]

The condition is frequently seen in skin clinics. [9] Males are affected more frequently than females. [3] One study showed that 65% of cases with tinea manuum were part of TFOHS. [6] [10] TFOHS was first described by Curtis in 1964. [11]

Signs and symptoms

TFOHS is a long-term fungal condition where athlete's foot or fungal toe nail infections in both feet is associated with tinea manuum in one hand. [3] [7] It typically presents with a diffuse scaling rash on the palm of one hand, which is preceded, sometimes by several years, by fungal infection in both feet. [3] Palmar creases appear prominent. [1] There is typically a sharp demarcation at the wrist. [12] Signs in a hand therefore require an examination of feet. [13]

Cause

TFOHS may follow scratching feet infected by fungi or occur after a pedicure. [3] The most common causative organism is Trichophyton rubrum . [3] [2] Typically, the hand that is used to scratch the infected feet or toes is the one that contracts tinea manuum. [14] Why the other hand is spared is not clear. [15] [16] In a case-control study that also looked at scratching habits, despite concluding that it was likely that tinea manuum develops in the hand that scratches the feet, some cases of TFOHS occurred in the hand that did not scratch the feet. [9]

Risk factors are the same as for athlete's foot and include excessive sweating and weakened immune system. [4] [6] Reinfection from contaminated socks may be possible. [4]

Diagnosis

Diagnosis of TFOHS is by visualisation, microscopy and culture from skin scrapings of the edge of the rash. [2] [11] The condition may appear similar to dermatitis, psoriasis, keratoderma, hyperkeratosis and allergic contact dermatitis. [5] It is sometimes misdiagnosed as hand eczema. [17]

Treatment

Treatment is with long-term systemic antifungals, typically oral terbinafine or itraconazole. [4] [8] Other options include fluconazole and griseofulvin. [4] Prevention is focused on hygiene measures such as keeping feet dry and applying antiseptic powder. [4] Using intermittent antifungal treatment in susceptible people, and avoiding scratching the feet or picking at fungal toenail infections are further preventative measures. [6] Avoiding washing socks in cold water may help, as well as dusting feet with Tolnaftate powder. [4] Dusting socks with talc, cornstarch or rice powder may help keep feet dry. [4]

Epidemiology

It is not known how many people have TFOHS. [6] Males are affected more frequently than females. [3] Athlete's foot is the most common fungal disease, with possibly more than 50% of the population affected at some time. [2] [4] Tinea manuum accounts for less than 2% of all superficial fungal infections. [2] Tinea manuum is rare in both hands. [2] Scenarios with one foot and two hands, and one foot and one hand, have been described. [15] One study showed that 65% of cases with tinea manuum were part of TFOHS. [6]

History

The condition was first described by Curtis in 1964. [11] It was later designated a syndrome. [11]

References

  1. 1 2 Johnstone, Ronald B. (2017). "25. Mycoses and Algal infections". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. p. 441. ISBN   978-0-7020-6830-0.
  2. 1 2 3 4 5 6 Schachtel, April; DeNiro, Katherine L. (2021). "22. Superficial dermatophyte infections of the skin". In Jong, Elaine C.; Stevens, Dennis L. (eds.). Netter's Infectious Diseases (Second ed.). Philadelphia: Elsevier. pp. 101–102. ISBN   978-0-323-71159-3.
  3. 1 2 3 4 5 6 7 8 9 10 11 Ginter-Hanselmayer, Gabriele; Nenoff, Pietro (2018). "10. Clinically Relevant Mycoses Dermatomycoses". In Presterl, Elisabeth (ed.). Clinically Relevant Mycoses: A Practical Approach. Springer. p. 154. ISBN   978-3-319-92299-7.
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "15. Diseases resulting from fungi and yeasts". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Elsevier. pp. 297–299. ISBN   978-0-323-54753-6.
  5. 1 2 3 Russell, James D.; McCall, Calvin O. (2015). "17. Infections in the kidney transplant recipient". In Nunley, Julia R.; Lerma, Edgar V. (eds.). Dermatological Manifestations of Kidney Disease. New York: Springer. p. 175. ISBN   978-1-4939-2394-6.
  6. 1 2 3 4 5 6 Chamorro, Monica J.; House, Steven A. (10 August 2020). "Tinea Manuum". StatPearls. StatPearls Publishing. PMID   32644474.
  7. 1 2 3 Rubin, Adam I.; Jellinek, Nathaniel J.; III, C. Ralph Daniel; Scher, Richard K. (2018). "9. Onychomycosis". Scher and Daniel's Nails: Diagnosis, Surgery, Therapy. Springer. p. 157. ISBN   978-3-319-65649-6.
  8. 1 2 Habif, Thomas P. (2016). "13. Superficial fungal infections". Clinical Dermatology (Sixth ed.). Elsevier. p. 492. ISBN   978-0-323-26183-8.
  9. 1 2 Acton, Ashton (2011). Advances in Tinea Research and Treatment: 2011 Edition: ScholarlyPaper. ScholarlyEditions. p. 3. ISBN   978-1-4649-5597-6.
  10. ↑ Zhan, Ping; Geng, Chengfang; Li, Zhihua; Jiang, Qing; Jin, Yun; Li, Caixia; Liu, Weida (August 2013). "The epidemiology of tinea manuum in Nanchang area, South China". Mycopathologia. 176 (1–2): 83–88. doi:10.1007/s11046-013-9673-9. ISSN   1573-0832. PMID   23765324. S2CID   14112962.
  11. 1 2 3 4 Bjekić, Milan (1 September 2015). "Two Feet-One Hand Syndrome: A Case Report / Sindrom dva stopala i jedne šake – prikaz slučaja". Acta Facultatis Medicae Naissensis. 32 (3): 215–219. doi: 10.1515/afmnai-2015-0022 .
  12. ↑ Marks (Jr.), James G.; Miller (Dermatologist), Jeffrey J. (2013). Lookingbill and Marks' Principles of Dermatology. Elsevier Health Sciences. p. 114. ISBN   978-1-4557-5014-6.
  13. ↑ Goodheart, Herbert P. (2010). Goodheart's Same-site Differential Diagnosis: A Rapid Method of Diagnosing and Treating Common Skin Disorders. Lippincott Williams & Wilkins. p. 187. ISBN   978-1-60547-746-6.
  14. ↑ Richardson, Malcolm D.; Warnock, David W. (2012). Fungal Infection: Diagnosis and Management. John Wiley & Sons. p. 111. ISBN   978-1-4051-7056-7.
  15. 1 2 Bikowski, Joseph (February 2014). "Update on Management of Dermatophytoses". Practical Dermatology: 23-26.
  16. ↑ Elston, Dirk (2009). "2. Fungal infections". Infectious Diseases of the Skin. Boca Raton: Manson publishing. p. 44. ISBN   978-1-84076-514-4.
  17. ↑ Lachapelle, Jean-Marie; Tennsdedt, Dominique (2014). "5. Other dermatoses affecting the hand: differential diagnosis". In Alikhan, Ali; Lachapelle, Jean-Marie; Maibach, Howard I. (eds.). Textbook of Hand Eczema. Springer. pp. 66–67. ISBN   978-3-642-39545-1.
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