UBE1L

UBA7
Identifiers
Aliases	UBA7 , D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7, UBE7
External IDs	OMIM: 191325; MGI: 1349462; HomoloGene: 2502; GeneCards: UBA7; OMA:UBA7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 49,805,209 bp [1] End 49,813,953 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 F1|9 59.07 cM Start 107,852,704 bp [2] End 107,861,259 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen right uterine tube lymph node appendix duodenum gallbladder right ovary left ovary right lobe of thyroid gland Top expressed in granulocyte spleen blood duodenum thymus mesenteric lymph nodes submandibular gland jejunum intestinal villus ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding ISG15 activating enzyme activity nucleotide binding ubiquitin-like modifier activating enzyme activity ligase activity protein binding ubiquitin-protein transferase activity ubiquitin activating enzyme activity Cellular component nucleoplasm cytosol cytoplasm nucleus Biological process negative regulation of type I interferon production ISG15-protein conjugation protein ubiquitination modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7318 74153 Ensembl ENSG00000182179 ENSMUSG00000032596 UniProt P41226 n/a RefSeq (mRNA) NM_003335 NM_023738 RefSeq (protein) NP_003326 n/a Location (UCSC) Chr 3: 49.81 – 49.81 Mb Chr 9: 107.85 – 107.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene. ^{[5] [6]}

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000182179 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032596 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. Bibcode:1993PNAS...90.6071K. doi: 10.1073/pnas.90.13.6071 . PMC   46869 . PMID   8327486.
6. "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

Further reading

• Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res. 52 (6): 1536–41. PMID   1311632.
• Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene". Gene Expr. 4 (3): 163–75. PMC   6134375 . PMID   7734949.
• McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi: 10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O . PMID   10709110.
• Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMC   133459 . PMID   11157743.
• Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. Bibcode:2002PNAS...99.3806K. doi: 10.1073/pnas.052011299 . PMC   122605 . PMID   11891284.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia". J. Biol. Chem. 279 (18): 18178–87. doi: 10.1074/jbc.M309259200 . PMID   14976209.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMC   1280211 . PMID   16254333.
• Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID   16428300.