UBE4A

Last updated
UBE4A
Protein UBE4A PDB 1wgm.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBE4A , E4, UBOX2, UFD2, ubiquitination factor E4A, NEDHMS
External IDs OMIM: 603753; MGI: 2154580; HomoloGene: 3517; GeneCards: UBE4A; OMA:UBE4A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004788
NM_001204077

NM_145400
NM_001346698
NM_001361075
NM_001361076

RefSeq (protein)

NP_001191006
NP_004779

NP_001333627
NP_663375
NP_001348004
NP_001348005

Location (UCSC) Chr 11: 118.36 – 118.4 Mb Chr 9: 44.83 – 44.88 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene. [5] [6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.

Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000110344 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059890 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell. 96 (5): 635–44. doi: 10.1016/S0092-8674(00)80574-7 . PMID   10089879.
  6. 1 2 "Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast)".

Further reading