UQCRH

UQCRH
Identifiers
Aliases	UQCRH , QCR6, UQCR8, ubiquinol-cytochrome c reductase hinge protein
External IDs	OMIM: 613844; MGI: 3641869; HomoloGene: 103848; GeneCards: UQCRH; OMA:UQCRH - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p33 Start 46,303,698 bp [1] End 46,316,776 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis left ventricle apex of heart right auricle of heart primary visual cortex superior frontal gyrus dorsolateral prefrontal cortex prefrontal cortex cerebellar hemisphere Brodmann area 9 n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquinol-cytochrome-c reductase activity Cellular component mitochondrial inner membrane respirasome membrane mitochondrion mitochondrial respirasome mitochondrial respiratory chain complex III Biological process aerobic respiration oxidative phosphorylation proton transmembrane transport mitochondrial electron transport, ubiquinol to cytochrome c Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7388 100042918 Ensembl ENSG00000173660 ENSMUSG00000037438 UniProt P07919 n/a RefSeq (mRNA) NM_006004 NM_001297565 NM_001297566 n/a RefSeq (protein) NP_001284494 NP_001284495 NP_005995 n/a Location (UCSC) Chr 1: 46.3 – 46.32 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene. ^{[4] [5]}

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".

References

1. GRCh38: Ensembl release 89: ENSG00000173660 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Ohta S, Goto K, Arai H, Kagawa Y (Jan 1988). "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein". FEBS Lett. 226 (1): 171–5. doi: 10.1016/0014-5793(87)80573-2 . PMID   2826252.
5. "Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein". Archived from the original on 2024-04-28. Retrieved 2017-09-17.

Further reading

• Liu AY, Bradner RC (1993). "Elevated expression of the human mitochondrial hinge protein gene in cancer". Cancer Res. 53 (11): 2460–5. PMID   7684318.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Modena P, Testi MA, Facchinetti F, et al. (2003). "UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines". Oncogene. 22 (29): 4586–93. doi: 10.1038/sj.onc.1206472 . hdl: 11380/740804 . PMID   12881716.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID   15544925.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.