Ultrastructural Pathology

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Electron microscope Type of microscope with electrons as a source of illumination

An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a higher resolving power than light microscopes and can reveal the structure of smaller objects. A scanning transmission electron microscope has achieved better than 50 pm resolution in annular dark-field imaging mode and magnifications of up to about 10,000,000× whereas most light microscopes are limited by diffraction to about 200 nm resolution and useful magnifications below 2000×.

Pathology Study of the causes and effects of disease or injury; the way a given disease or injury presents itself.

Pathology is the study of the causes and effects of disease or injury. The word pathology also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a more narrow fashion to refer to processes and tests which fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue, cell, and body fluid samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases, and the affix pathy is sometimes used to indicate a state of disease in cases of both physical ailment and psychological conditions. A physician practicing pathology is called a pathologist.

Anatomical pathology

Anatomical pathology (Commonwealth) or Anatomic pathology (U.S.) is a medical specialty that is concerned with the diagnosis of disease based on the macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues. Over the last century, surgical pathology has evolved tremendously: from historical examination of whole bodies (autopsy) to a more modernized practice, centered on the diagnosis and prognosis of cancer to guide treatment decision-making in oncology. Its modern founder was the Italian scientist Giovan Battista Morgagni from Forlì.


Ultrastructure is the architecture of cells and biomaterials that is visible at higher magnifications than found on a standard optical light microscope. This traditionally meant the resolution and magnification range of a conventional transmission electron microscope (TEM) when viewing biological specimens such as cells, tissue, or organs. Ultrastructure can also be viewed with scanning electron microscopy and super-resolution microscopy, although TEM is a standard histology technique for viewing ultrastructure. Such cellular structures as organelles, which allow the cell to function properly within its specified environment, can be examined at the ultrastructural level.

Frederick Thomas Zugibe was the chief medical examiner of Rockland County, New York from 1969 to 2002. Zugibe was one of the United States' most prominent forensics experts, known for his research and books on forensic medicine as well as his crucifixion and Shroud of Turin studies.

Pulmonary alveolar proteinosis

Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by an abnormal accumulation of surfactant-derived lipoprotein compounds within the alveoli of the lung. The accumulated substances interfere with the normal gas exchange and expansion of the lungs, ultimately leading to difficulty breathing and a predisposition to developing lung infections. The causes of PAP may be grouped into primary, secondary, and congenital causes, although the most common cause is a primary autoimmune condition in an individual.

Thermo Fisher Scientific provisioner of scientific consumables, equipment, and services

Thermo Fisher Scientific is an American provisioner of scientific instrumentation, reagents and consumables, and software and services to healthcare, life science, and other laboratories in academia, government, and industry. Based in Waltham, Massachusetts, Thermo Fisher was created in 2006 by the merger of Thermo Electron and Fisher Scientific, to form a company with US$ 9 billion in combined revenues.

Gross examination

Gross examination or "grossing" is the process by which pathology specimens are inspected with the bare eye to obtain diagnostic information, while being processed for further microscopic examination.

Medical laboratory

A medical laboratory or clinical laboratory is a laboratory where tests are carried out on clinical specimens to obtain information about the health of a patient to aid in diagnosis, treatment, and prevention of disease. Clinical Medical laboratories are an example of applied science, as opposed to research laboratories that focus on basic science, such as found in some academic institutions.

Perls Prussian blue Histologic method to stain for iron

Perls Prussian blue is a commonly used method in histology, histopathology, and clinical pathology to detect the presence of iron in tissue or cell samples. Perls Prussian Blue derives its name from the German pathologist Max Perls (1843–1881), who described the technique in 1867. The method does not involve the application of a dye, but rather causes the pigment Prussian blue to form directly within the tissue. The method stains mostly iron in the ferric state which includes ferritin and hemosiderin, rather than iron in the ferrous state.

<i>Journal of Clinical Pathology</i> Academic journal

The Journal of Clinical Pathology (JCP) is a peer-reviewed medical journal covering all aspects of pathology, published by the BMJ Group and co-owned by the Association of Clinical Pathologists. Diagnostic and research areas covered include histopathology, virology, haematology, microbiology, cytopathology, chemical pathology, molecular pathology, forensic pathology, dermatopathology, neuropathology, and immunopathology. Each issue contains reviews, original articles, short reports, case reports, correspondence, and book reviews.

The American Journal of Pathology is a monthly peer-reviewed medical journal covering pathology. It is published by Elsevier on behalf of the American Society for Investigative Pathology, of which it is an official journal. The editor-in-chief is Martha B. Furie. The journal was established in 1896 as the Journal of the Boston Society of Medical Sciences and renamed The Journal of Medical Research in 1901, before obtaining its current title in 1925. According to the Journal Citation Reports, the journal has a 2016 impact factor of 4.057.

Sertoli cell nodule

A Sertoli cell nodule is a benign proliferation of Sertoli cells that arises in association with cryptorchidism. They are not composed of a clonal cell population, i.e. neoplastic; thus, technically, they should not be called an adenoma.

"Autoschizis" is a term derived from the Greek αὐτο- auto-, meaning "self", and σχίζειν skhizein, "to split". It was introduced in 1998 to describe a novel form of cancer cell death characterized by a reduction in cell size that occurs due to the loss of cytoplasm through self-excision without the loss of cell organelles, morphologic degradation of the cells nucleus and nucleolus without the formation of apoptotic bodies and destruction of the cell membrane. The cell death results from karyorrhexis and karyolysis. Autoschizis can be initiated via in vivo treatment with vitamin C (VC), synthetic vitamin K (VK3) or, better, a combination of both. The treatment has been tested on various types of cancer cells in vitro and in vivo with positive results.

Histopathology is a peer-reviewed medical journal covering diagnostic, research, and surgical pathology. It was established in 1977 and is published monthly by Wiley-Blackwell. It is currently edited by Alastair Burt. Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. The primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease.

Étienne de Harven

Etienne de Harven (1928-2019) was a Belgian-born pathologist and electron microscopist. Born in Brussels, he did most of his work in New York City, Paris and Toronto. He did pioneering research on viruses, mostly related to murine leukemia. He is former President of the Electron Microscopy Society of America.

<i>Journal of Veterinary Diagnostic Investigation</i> Academic journal

The Journal of Veterinary Diagnostic Investigation is an international peer-reviewed academic journal published bimonthly in English that publishes papers in the field of Veterinary Sciences. The journal's editor is Grant Maxie, DVM, PhD, DACVP. The Journal has been in publication since 1989 and is currently published by SAGE Publications in association with American Association of Veterinary Laboratory Diagnosticians, Inc.

Veterinary Pathology is a peer-reviewed academic journal that publishes papers in the field of Pathology. As of 2017, the journal's editor is Jeff L. Caswell, Pathology Professor at the University of Guelph. It has been in publication since 1964 and is currently published by SAGE Publications, in association with the American College of Veterinary Pathologists, the European College of Veterinary Pathologists, and the Japanese College of Veterinary Pathologists.

The Journal of Molecular Diagnostics is a peer-reviewed medical journal covering research on molecular biological applications to diagnostics. It is published by Elsevier on behalf of the American Society for Investigative Pathology and the Association for Molecular Pathology. The editor-in-chief is Barbara Zehnbauer. The journal was established in 1999 as The American Journal of Pathology, Part B, with Nelson Fausto as founding editor.

Human Pathology is a monthly peer-reviewed medical journal covering pathology in humans. It was established in 1970 and is published by Saunders. The editor-in-chief is Dr. Lori Erickson. According to the Journal Citation Reports, the journal has a 2016 impact factor of 3.014.


  1. "Editorial Board". informahealthcare.com. Retrieved 2010-01-20.
  2. "Ultrastructural Pathology". 2016 Journal Citation Reports . Web of Science (Social Sciences ed.). Thomson Reuters. 2017.