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Uncle Fester is the pen name of Steve Preisler, [1] author of such controversial books as Secrets of Methamphetamine Manufacture and Silent Death.
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Uncle Fester is the pen name of Steve Preisler, [1] author of such controversial books as Secrets of Methamphetamine Manufacture and Silent Death.
Preisler gained underground fame after publishing his first book Secrets of Methamphetamine Manufacture in the early 1980s. He says that he got the nickname "Uncle Fester" from his college years, since he was very well known for producing explosives, and blowing things up, like the character in The Addams Family .
Preisler is an industrial chemist working in an electroplating factory he calls "the rat hole." In his spare time, he writes books. Preisler graduated in 1981 from Marquette University with a Chemistry & Biology degree. Two years later, he was arrested for methamphetamine possession and was sentenced to probation. He was arrested again in 1984 for methamphetamine charges, and put in the Waupun Correctional Institution. He says that the arrest was over a few grams of methamphetamine, but the Drug Enforcement Administration (DEA) brought back credit card information saying that he had been buying large quantities of ephedrine, which is a precursor for methamphetamine.
Outraged, Fester borrowed a typewriter from a fellow inmate, and began writing the manuscript for Secrets of Methamphetamine Manufacture. Loompanics Unlimited published the book, and it was an instant success. Secrets of Methamphetamine Manufacture is now in its eighth edition. It was one of Loompanics' best sellers. The book has information on how to produce crystal methamphetamine through six different methods. It also has data on how to synthesize MDMA or MDA, and how to synthesize methcathinone by oxidation of ephedrine. It also contains syntheses for precursor materials such as phenylacetone, ephedrine, methylamine, and alkyl nitrites. Previous editions of Secrets of Methamphetamine Manufacture have had some criticism: see for example Eleusis v. Fester for discussion between Fester and the past MDMA clandestine chemist Eleusis/Zwitterion.
Uncle Fester has since written six other books:
Preisler was arrested at his home in Green Bay on July 14, 2023. He was charged on July 17. Two years after his interview with Vice TV, where he showed how to cook meth, just without finishing the cook. [4]
Preisler was the object of the 40-minute documentary film "Friction", by Robert Ellman, made at a cost of approximately $300,000, whose premiere on Czech Television was cancelled after the September 11 attacks rendered the topic "politically incorrect". [5]
Preisler was also featured in season 3 episode 2 of VICE's Hamilton's Pharmacopeia , which covered the production process, history, and several users' experience of methamphetamine. [6]
3,4-Methyl
Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit in nasal congestion. It can be taken by mouth or by injection into a muscle, vein, or just under the skin. Onset with intravenous use is fast, while injection into a muscle can take 20 minutes, and by mouth can take an hour for effect. When given by injection it lasts about an hour and when taken by mouth it can last up to four hours.
Methcathinone is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone. It is used as a recreational drug due to its potent stimulant and euphoric effects and is considered to be addictive, with both physical and psychological withdrawal occurring if its use is discontinued after prolonged or high-dosage administration. It is usually snorted, but can be smoked, injected, or taken orally.
PiHKAL: A Chemical Love Story is a book by Dr. Alexander Shulgin and Ann Shulgin, published in 1991. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics and/or empathogen-entactogens. The main title, PiHKAL, is an acronym that stands for "Phenethylamines I Have Known and Loved."
Clandestine chemistry is chemistry carried out in secret, and particularly in illegal drug laboratories. Larger labs are usually run by gangs or organized crime intending to produce for distribution on the black market. Smaller labs can be run by individual chemists working clandestinely in order to synthesize smaller amounts of controlled substances or simply out of a hobbyist interest in chemistry, often because of the difficulty in ascertaining the purity of other, illegally synthesized drugs obtained on the black market. The term clandestine lab is generally used in any situation involving the production of illicit compounds, regardless of whether the facilities being used qualify as a true laboratory.
3,4-Methylenedioxyamphetamine is an empathogen-entactogen, psychostimulant, and psychedelic drug of the amphetamine family that is encountered mainly as a recreational drug. In its pharmacology, MDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA). In most countries, the drug is a controlled substance and its possession and sale are illegal.
David Earl Nichols is an American pharmacologist and medicinal chemist. Previously the Robert C. and Charlotte P. Anderson Distinguished Chair in Pharmacology at Purdue University, Nichols has worked in the field of psychoactive drugs since 1969. While still a graduate student, he patented the method that is used to make the optical isomers of hallucinogenic amphetamines. His contributions include the synthesis and reporting of escaline, LSZ, 6-APB, 2C-I-NBOMe and other NBOMe variants, and several others, as well as the coining of the term "entactogen".
Phenylacetone, also known as phenyl-2-propanone, is an organic compound with the chemical formula C6H5CH2COCH3. It is a colorless oil that is soluble in organic solvents. It is a mono-substituted benzene derivative, consisting of an acetone attached to a phenyl group. As such, its systematic IUPAC name is 1-phenyl-2-propanone.
Hobart Huson, also known as Strike, is the founder and site designer of online forum The Hive and author of several popular books such as Total Synthesis I and II, and Sources, in which he details methods of synthesizing a variety of amphetamines, obtaining equipment and chemicals, and avoiding prosecution for said activity. From his books, it is clear that MDMA was the drug he found to be most compelling : in the book, he describes it as "the most benign drug [I have] ever encountered."
1-Phenyl-2-nitropropene, or simply phenyl-2-nitropropene, or P2NP, as it is commonly referred to, is a chemical compound from the aromatic group of compounds, with the formula C9H9NO2. It is a light-yellow crystalline solid with a distinct smell. Phenyl-2-nitropropene is used in the pharmaceutical industry to manufacture the drug Adderall, an amphetamine mixture used to treat ADHD and narcolepsy. P2NP and other similar nitrostyrenes are also employed in the clandestine manufacture of drugs of the amphetamine class, and are listed as drug precursors in many countries.
2,5-Dimethoxy-3,4-methylenedioxyamphetamine is a lesser-known psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized by Alexander Shulgin and was described in his book PiHKAL. Shulgin listed the dosage as 30–75 mg and the duration as 6–8 hours. He reported DMMDA as producing LSD-like images, mydriasis, ataxia, and time dilation. DMMDA isn't mentioned much in literature outside PiHKAL unlike 2C-B.
Methamphetamine is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical substance, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms, but the hydrochloride salt, commonly called crystal meth, is widely used. Methamphetamine is rarely prescribed over concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy such as Adderall and Vyvanse. Dextromethamphetamine is a stronger CNS stimulant than levomethamphetamine.
Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents. The compounds in this class span a variety of pharmacological subclasses, including stimulants, empathogens, and hallucinogens, among others. Examples of substituted amphetamines are amphetamine (itself), methamphetamine, ephedrine, cathinone, phentermine, mephentermine, tranylcypromine, bupropion, methoxyphenamine, selegiline, amfepramone (diethylpropion), pyrovalerone, MDMA (ecstasy), and DOM (STP).
Akira Ogata was a Japanese chemist and the first to synthesize methamphetamine in crystalline form in 1919.
Drug precursors, also referred to as precursor chemicals or simply precursors, are substances used to manufacture illicit drugs. Most precursors also have legitimate commercial uses and are legally used in a wide variety of industrial processes and consumer products, such as medicines, flavourings, and fragrances.
Methamphetamine in the United States is regulated under Schedule II of the Controlled Substances Act. It is approved for pharmacological use in the treatment of attention deficit hyperactivity disorder, narcolepsy, and treatment-resistant obesity, but it is primarily used as a recreational drug. In 2012, 16,000 prescriptions for methamphetamine were filled, approximately 1.2 million Americans reported using it in the past year, and 440,000 reported using the drug in the past month.
Amphetamine and methamphetamine are central nervous system stimulants used to treat a variety of conditions. When used recreationally, they are colloquially known as "speed" or sometimes "crank". Amphetamine was first synthesized in 1887 in Germany by Romanian chemist Lazăr Edeleanu, who named it phenylisopropylamine. Around the same time, Japanese organic chemist Nagai Nagayoshi isolated ephedrine from the Chinese ephedra plant and later developed a method for ephedrine synthesis. Methamphetamine was synthesized from ephedrine in 1893 by Nagayoshi. Neither drug had a pharmacological use until 1934, when Smith, Kline & French began selling amphetamine as an inhaler under the trade name Benzedrine for congestion.
Entheogenic drugs have been used by various groups for thousands of years. There are numerous historical reports as well as modern, contemporary reports of indigenous groups using entheogens, chemical substances used in a religious, shamanic, or spiritual context.
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