VARS

For other uses, see Vars (disambiguation).

VARS1
Identifiers
Aliases	VARS1 , VARS, NDMSCA, valyl-tRNA synthetase 1, G7A, VARS2, valyl-tRNA synthetase
External IDs	OMIM: 192150 MGI: 90675 HomoloGene: 4587 GeneCards: VARS1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 31,777,518 bp [1] End 31,795,752 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B1|17 18.54 cM Start 35,219,963 bp [2] End 35,235,298 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans pituitary gland ganglionic eminence appendix anterior pituitary stromal cell of endometrium gastrocnemius muscle muscle tissue skeletal muscle tissue body of pancreas Top expressed in spermatid seminiferous tubule yolk sac spermatocyte lip somite internal carotid artery crypt of lieberkuhn of small intestine thymus external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity protein binding ATP binding aminoacyl-tRNA editing activity valine-tRNA ligase activity Cellular component cytoplasm cytosol Biological process tRNA aminoacylation for protein translation protein biosynthesis valyl-tRNA aminoacylation aminoacyl-tRNA metabolism involved in translational fidelity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7407 22321 Ensembl ENSG00000226589 ENSG00000096171 ENSG00000231945 ENSG00000227686 ENSG00000204394 ENSG00000224264 ENSG00000231116 ENSMUSG00000007029 UniProt P26640 Q9Z1Q9 RefSeq (mRNA) NM_006295 NM_011690 RefSeq (protein) NP_006286 NP_006286.1 NP_035820 Location (UCSC) Chr 6: 31.78 – 31.8 Mb Chr 17: 35.22 – 35.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Valyl-tRNA synthetase is an enzyme that in humans is encoded by the VARS gene. ^{[5] [6]}

Function

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. ^[6]

See also

• Valine-tRNA ligase

References

1. ENSG00000096171, ENSG00000231945, ENSG00000227686, ENSG00000204394, ENSG00000224264, ENSG00000231116 GRCh38: Ensembl release 89: ENSG00000226589, ENSG00000096171, ENSG00000231945, ENSG00000227686, ENSG00000204394, ENSG00000224264, ENSG00000231116 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007029 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (March 2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry. 44 (12): 4805–16. doi:10.1021/bi047527z. PMID   15779907.
6. "Entrez Gene: VARS valyl-tRNA synthetase".

Further reading

• Hsieh SL, Campbell RD (September 1991). "Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase". The Biochemical Journal. 278 (3): 809–16. doi:10.1042/bj2780809. PMC   1151418 . PMID   1898367.
• Sargent CA, Dunham I, Campbell RD (August 1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region". The EMBO Journal. 8 (8): 2305–12. doi:10.1002/j.1460-2075.1989.tb08357.x. PMC   401163 . PMID   2477242.
• Bec G, Kerjan P, Zha XD, Waller JP (December 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry. 264 (35): 21131–7. doi: 10.1016/S0021-9258(19)30056-0 . PMID   2556394.
• Wolfson AD, Orlovsky AF, Gladilin KL (October 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters. 238 (2): 262–4. Bibcode:1988FEBSL.238..262M. doi: 10.1016/0014-5793(88)80492-7 . PMID   3169261. S2CID   45934458.
• Bec G, Kerjan P, Waller JP (January 1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry. 269 (3): 2086–92. doi: 10.1016/S0021-9258(17)42139-9 . PMID   8294461.
• Vilalta A, Donovan D, Wood L, Vogeli G, Yang DC (January 1993). "Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase". Gene. 123 (2): 181–6. doi:10.1016/0378-1119(93)90122-J. PMID   8428657.
• Motorin Y (May 1996). "Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences". Gene. 170 (2): 289–91. doi:10.1016/0378-1119(96)84699-3. PMID   8666263.
• Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (December 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC   403804 . PMID   14656967.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Jiang S, Wolfe CL, Warrington JA, Norcum MT (November 2005). "Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit". FEBS Letters. 579 (27): 6049–54. Bibcode:2005FEBSL.579.6049J. doi: 10.1016/j.febslet.2005.09.062 . PMID   16229838. S2CID   83645345.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.