Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene. [5]
This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated protein. The two other subunits of ESCRT-I are vacuolar protein sorting 23 (VPS23), also known as tumor susceptibility gene 101 (TSG101), and vacuolar protein sorting 37 (VPS37). Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally. [5]
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.
Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.
Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.
Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.
Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.
Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.
VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.
Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.
Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.
Charged multivesicular body protein 4a is a protein that in humans is encoded by the CHMP4A gene.
Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.
Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.
Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.
Charged multivesicular body protein 1b is a protein that in humans is encoded by the CHMP1B gene.
Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.
Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.
Vacuolar protein sorting-associated protein 33A is a protein that in humans is encoded by the VPS33A gene.
Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.
The endosomal sorting complexes required for transport (ESCRT) machinery is made up of cytosolic protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II, and ESCRT-III. Together with a number of accessory proteins, these ESCRT complexes enable a unique mode of membrane remodeling that results in membranes bending/budding away from the cytoplasm. These ESCRT components have been isolated and studied in a number of organisms including yeast and humans.
Vacuolar protein sorting 37 homolog A is a protein in humans that is encoded by the VPS37A gene. It is a member of the endosomal sorting complex required for transport (ESCRT) system.
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