WFIKKN1

WFIKKN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DDI, 2DDJ
Identifiers
Aliases	WFIKKN1 , C16orf12, RJD2, WFDC20A, WFIKKN, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
External IDs	OMIM: 608021 MGI: 2670967 HomoloGene: 14244 GeneCards: WFIKKN1
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 629,239 bp [1] End 634,117 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 26,096,602 bp [2] End 26,099,832 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland putamen Brodmann area 9 anterior pituitary nucleus accumbens skin of abdomen caudate nucleus right uterine tube right lobe of thyroid gland amygdala Top expressed in primitive streak somite morula yolk sac ascending aorta aortic valve abdominal wall blastocyst dermis cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity enzyme inhibitor activity protein binding metalloendopeptidase inhibitor activity serine-type endopeptidase inhibitor activity receptor antagonist activity transforming growth factor beta binding Cellular component extracellular region Biological process skeletal system development negative regulation of DNA binding roof of mouth development negative regulation of peptidase activity negative regulation of protein binding negative regulation of endopeptidase activity negative regulation of transforming growth factor beta receptor signaling pathway extracellular negative regulation of signal transduction negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117166 215001 Ensembl ENSG00000127578 ENSMUSG00000071192 UniProt Q96NZ8 Q8R0S6 RefSeq (mRNA) NM_053284 NM_001100454 RefSeq (protein) NP_444514 NP_001093924 Location (UCSC) Chr 16: 0.63 – 0.63 Mb Chr 17: 26.1 – 26.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene. ^{[5] [6] [7]} when found in humans.

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000127578 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071192 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A. 98 (7): 3705–9. Bibcode:2001PNAS...98.3705T. doi: 10.1073/pnas.061028398 . PMC   31116 . PMID   11274388.
6. Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID   11928817. S2CID   37069938.
7. "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1".

Further reading

• Liepinsh E, Nagy A, Trexler M, et al. (2006). "Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein". J. Biomol. NMR. 35 (1): 73–8. doi:10.1007/s10858-006-9013-1. PMID   16791741. S2CID   34083234.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Nagy A, Trexler M, Patthy L (2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". Eur. J. Biochem. 270 (9): 2101–7. doi: 10.1046/j.1432-1033.2003.03593.x . PMID   12709070.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.