Wladimir Wertelecki

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Wladimir Wertelecki, M.D.jpg
Wladimir Wertelecki
Born(1936) In Rivne, Volyn, Ukraine (at the time Poland)
CitizenshipUSA
Fields Clinical Teratology, Genetics and Pediatrics
EducationNational San Fernando Highschool, Buenos Aires, Argentina
Mentors Taras Mykysha  [ uk ], Volodymyr Lasovskyi  [ uk ], Bernardo Houssay, Niсeto S. Loizaga, M.D., [1] Alexis Hartmann, [2] Harold Cummins, PhD., [3] Josef Warkany, Daniel C. Gajdusek, John Gofman
Alma materMedical School, University of Buenos Aires, Argentina (1956–1961)
PostgraduateIntern, Muniz Hospital, Buenos Aires, Argentina (1961 - 1962). Intern, Deaconess Hospital, St. Louis, MO, U.S. (1963). Resident in Pediatrics, St. Louis Children's Hospital and Washington University Medical School, St. Louis, MO (1964 - 1966). Fellow in Clinical Genetics, Boston Children's Hospital and Harvard Medical School, Boston, MA (1966 - 1968)
Academic Posts and TenuresInstructor, Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA (1968–1969). Senior Surgeon, U.S. Public Health Commissioned Corps., Epidemiology Branch, National Cancer Institute, Bethesda, MD (1969–1972). Assistant Professor, Pediatrics, Medical University of South Carolina, Charleston, SC (1972). Associate Professor, Pediatrics and Pathology, Medical University of South Carolina, Charleston, SC (1973–1974). Professor and chairman, Department of Medical Genetics, University of South Alabama, Mobile, AL (1974–2010). Professor Emeritus, University of South Alabama, Mobile, AL (2010-). Director, OMNI-Net Ukraine, Birth Defects Monitoring Programs (1999-)
Awards and Honors Corresponding Member of the "Academia Nacional de Medicina" (Buenos Aires, Argentina) and Foreign Member of the National Academy of Sciences (Kyiv, Ukraine), Doctor Honoris Causa, National University of Kyiv-Mohyla Academy (Kyiv, Ukraine) and Lviv Medical University (Lviv, Ukraine)
CurrentDirector of OMNI-Net Programs in Ukraine. International Coordinator of CIFASD investigations in Ukraine. Investigations of teratogenesis of Chornobyl radionuclides.

Wladimir Wertelecki is a board certified pediatrician, clinical geneticist and cytogeneticist. In 1974, he established one of the first free-standing Departments of Medical Genetics [4] at the University of South Alabama College of Medicine in Mobile, Alabama, U.S.A. Following his retirement as chairman and emeritus Professor of Medical Genetics, Pediatrics, and Pathology, he continued his investigations into the prevention of developmental anomalies as a Project Scientist at the Department of Pediatrics, University of California, San Diego. Since 1996, his research has focused mainly on alcohol and the impact of ionizing radiation on congenital anomalies. He is the author over 147 scientific reports. [5]

Contents

He established a regional network of clinics across southern Alabama and West Florida, and in 1978 he organized the Southern Genetic Group. This group expanded into the South-Eastern Regional Genetics Group, to enhance regional genetic services. [6] Components of this network provided templates for the population-based surveillance system implemented later in Chornobyl-impacted regions in Ukraine. Wertelecki also helped local Native-Americans gain Federal Recognition in Alabama. [7] [8]

In 1992, he made a presentation to the US Senate regarding the reproductive risks posed by Chornobyl radiation. [9] In 1999, following an initial sponsorship by USAID, he established the OMNI-Net program, a not-for-profit network, to investigate the reproductive risks posed by exposure to alcohol and ionizing radiation from Chornobyl. [10] Wertelecki is the International Cooordinator of the OMNI-Net programs. OMNI-Net conducts population-based birth defects surveillance, is a full member of EUROCAT and ICBDSR, trains clinicians and provides medical assistance. Wertelecki is the editor of several internet sites related to OMNI-Net. Wertelecki also is the author of articles, related to history and overviews of Human Teratology and other subjects. [11] [12]

Medical and Postgraduate Education and Clinical Training

Wertelecki began his medical education in 1955 at the School of Medicine of the University of Buenos Aires. As a medical student, he took additional courses to qualify as a teaching assistant in Human Anatomy (1957) and in physiology (1958).

These extracurricular courses proved to be formative. In anatomy, he observed an instance of anatomic atavism ("maneus muscle" [13] ) which stimulated his interest in anatomical variants, anomalies, and evolution. [14] His interest in physiology enabled him to join a research team headed by Dr. Virgilio G. Foglia, [15] [16] and coordinated by Dr. Bernardo Houssay, a Nobel Prize winner regarding diabetes mellitus impact on reproduction. [17] As a student of clinical medicine, Wertelecki was granted a university scholarship and became an assistant to Dr. Niceto S. Loizaga, [18] an expert in semiology [19] and zoonosis [16] (skills to recognize signs as signals of syndromes and diagnoses) (1958–1961). Next, Wertelecki completed a rotating internship at Deaconess Hospital, Saint Louis (1962-1963) and became a pediatric resident (1963–1965) at the Department of Pediatrics, St. Louis Children's Hospital and Washington University in St. Louis headed by Dr. Alexis F. Hartmann, one of the first to use insulin to treat diabetic children. [20] Wertelecki's sought further training in Clinical Genetics as a fellow at the Boston Children's Hospital and Harvard Medical School (1965–1968). His tasks included participation in the Phenylketonuria Treatment Clinic [21] and the development of computer-aided programs to gather family reproductive histories. [22]

Initial Investigations of Clinical Patterns

During 1968–1970, Wertelecki studied Clinical Epidemiology while serving as a Senior Surgeon (Commander) of the US Public Health Corp at the Epidemiology Branch of the National Cancer Institute and consultant in Medical Genetics at the Naval National Medical Center in Bethesda, Maryland. In 1973, access to computerized medical records permitted a large epidemiologic analysis of epileptic women elevated risks to deliver children with facial clefts attributed to anti-epileptic therapies later confirmed to include such agent as “Dilantin” (phenytoin), described as fetal hydantoin syndrome in 1975. [23] Anti-epileptic medications often reduced available folates to developing embryos was suspect of being teratogenic. Fifteen years later (1988) mandatory folic acid fortification of cereal/grain products was introduced to reduce prevalence if spina bifida. Analyses of birthweight and dermatoglyphic patterns of fingers and palms of leukemic children revealed statistically significant contrast indicative of prenatal factors, subsequently amply confirmed. [24] [25] The mentors and associates of these investigations included Mr. Nathan Mantel, Dr. Robert W. Miller, Dr. C.C. Plato, and Dr. Josef Warkany. Their collective contribution accepted notion of the association of congenital anomalies and factors with pediatric neoplasias. [26] This association is evident following in utero exposures to ionizing radiation. Wertelecki often relied on his expertise in clinical semiology to report early clinical observations. [25] [27] [28] The first clinical scientific report by Wertelecki as a junior resident of pediatrics concerned the recognition of cantharidin-related nephritis in children linked with blister beetles. [29] As a research fellow of Medical Genetics and instructor of Pediatrics Wertelecki reported  stigmatic signs for the recognition of rare and novel syndrome of a partial monosomy (deletion) of a segment of chromosome 18. [24] At the time such deletions were considered lethal. [25] [28] [30]  He also reported results of early treatments of phenylketonuria. [21] Recognition of triploidy was synthesized by Wertelecki, his students and colleagues. [31] [32] Another early synthesis of perhaps the first human observations of a disorder known in cattle its molecular characteristics was named dermatosparaxis, a collagen disorder. [33] [34] [35] Studies of population isolates led to identifications of novel gene mutations and their clinical manifestations. Investigations of an isolate of a Native American population identified a gene mutation manifested as the Marinesco-Sjögren syndrome. The investigations expanded clinical spectrum of the disorder. Also facilitated the Federal recognition of a population as an Indian tribe. [36] [37] [38] [39] [40] Another investigation of a different population isolate led to the identification of the gene mutation manifested as acoustic neuromas, spinal tumors, and other neoplasias. The studies led to the current notions of Neurofibromatosis type II and discovery of the crucial tumor suppressor protein known as Merlin protein. [41] [42] [43] [44] [45] [46] [47] [48]

Academic Teaching and Research

As a professor and, eventually, chairman of a novel Department of Medical Genetics, Wertelecki recruited as visiting professors Drs J. Warkany, founder of a Teratology Society, and Dr. H. Zellweger, a pioneer of Pediatric Neurology. They contributed to the full range of programs sponsored by the Department. [11] [12] The Department was the prime organizer of the Southeastern Regional Genetics Group dedicated to coordinating regional resources and clinical services along with initiatives to promote computer-driven data collection of genetic services. His department became an accredited site for training physicians in Clinical Genetics and Clinical Cytogenetics. In addition to U.S. graduates, international trainees included those from Japan, Argentina, Brazil, Sri Lanka, China, India, among others.

Following the 1986 Chornobyl disaster Wertelecki organized a workshop during the 1991 International Congress of Human Genetics with a focus upon the potential teratogenic impacts of Chornobyl radionuclides on human embryos. In 1992, [9] Wertelecki was invited to address a U.S. Senate Committee regarding Chornobyl and child health. In 1996, he received a grant from the National Institute of Child Health and Human Development to organize a Symposium during the Human Genetics International Congress of 1996 on the subject of Chornobyl radiation impacts on child development. The participating International experts, including those from Belarus and Ukraine, defined areas of concern and potential investigations. Wertelecki sought further advice from John William Gofman (Professor Emeritus of Molecular and Cell Biology at University of California at Berkeley), Daniel Carleton Gajdusek (Pediatrician winner of the Nobel Prize for the discovery of the human prion disease), Jennifer L Howse (President of the March of Dimes Foundation), Mike Katz (vice-president for Science, March of Dimes Foundation), and Godfrey Oakley(Director of the Division of Birth Defects of the U.S. Centers for Disease Control and Prevention), among others.

Chornobyl - Ukraine

In 1999, a plan to establish a population based monitoring of birth defects upholding international standards in several regions of Ukraine was submitted and approved by the Ukrainian Ministry of Health, Wertelecki accepted to be the director of the project now referred to as OMNI-Net Ukraine Programs. In 2000, with initial support from the USAID, population surveillance of birth defects monitoring was initiated. [10] In 2002, OMNI-Net data documented a high frequency of spina bifida, which persists to the present. [49] [50] [51] Since then, OMNI-Net members advocate for the introduction of mandatory fortification of flour with folic acid to reduce spina bifida and related disorders by at least 50%.

In 2006, OMNI-Net qualified for full membership of the European birth defects monitoring network (EUROCAT) and became a participant in the Collaborative Initiative of Fetal Alcohol Spectrum Consortium (CIFASD). [52] The results indicate that pregnant women residing in Polissia region of Rivne province which were polluted by Chornobyl radionuclides had statistically significantly higher incorporated Cs-137 radionuclides compared to those residing in not-Polissia concurrently with population-based rates of developmental anomalies also statistically significantly higher in Polissia than in not-Polissia. [49] [53] [54] This cause-effect association is considered by OMNI-Net partners lead by Wertelecki to be proven. However, they consider prudent that it must be promptly confirmed to be followed by Public Health policies to reduce to zero in-utero exposures to Chornobyl radionuclides and other sources of ionizing radiation.

During 2008 OMNI-Net joined the CIFASD network and Wertelecki accepted to be the International Coordinator of implementations in Ukraine under the direction of Dr. Christina Chambers Project Director, Department of Pediatrics, UCSD. The aim of the implementations is to define prenatal exposures to alcohol in large cohort and controls of exposed embryos and postnatal developmental parameters. The program is ongoing. [52]

Honors and Awards

Amond others:

Organizations

Among others, past and current:

Selected Scientific Publications

(among others, for complete bibliography please see PubMed [60] )

Selected Early Publications

Selected Scientific Publications post Chornobyl

Books, chapters and other publications (partial list)

  1. Wertelecki, W., Lawton, T., Gerald, P.S.: Computer-Based Patient Interviewing. In: Computer-Assisted Instruction in the Health Professions. Eds., Stolurow, L.M., Peterson, T.I., Cunningham, A.C., Entelek, Inc., Newburyport, MA (1970).
  2. Wertelecki, W., Peterson, R.D.A.: Primary Immunodeficiency Syndromes. In: Surgical Immunology. Ed., Munster, A.M., Grune Publishers, New York, NY (1976).
  3. Wertelecki, W.: Regional Rural Genetics Program: Educational Considerations. In: The Management of Genetic Disorders. Eds., Bartsocas, C.S., Papadatos, C., Alan R. Liss Publishers, New York, NY (1979).
  4. Wertelecki, W., Plato, C., Editors: Dermatoglyphics – 50 Years Later. (Birth Defects Original Article Series Vol. XV, No. 6). Alan R. Liss Publishers, New York, NY (1979).
  5. Wertelecki, W.: Tetraploidy. In: Handbook of Clinical Neurology, Neurogenetic Directory. Ed., Myrianthopoulas, N.C., Part II, North-Holland Publishing Co., Amsterdam (1982).
  6. Castilla, E., Penchaszadeh, V., Wertelecki, W., Youlton, R.: Prevention and Control of Genetic Diseases and Congenital Defects: Report of an Advisory Group. Pan American Health Organization/World Health Organization, 525 Twenty-Third Street, Washington, D.C., Scientific Publication No. 460 (1984).
  7. Wertelecki, W.: Roberts Syndrome. Birth Defects Encyclopedia, 3rd Edition, Buyse, M.L., Editor. Blackwell/Year Book Medical Publishers, Inc. pp. 1498-1499 (1990).
  8. Wertelecki, W.: Chromosome 22. Birth Defects Encyclopedia, 3rd Edition, Buyse, M.L., Editor. Blackwell/Year Book Medical Publishers, Inc. pp. 395 (1990).
  9. Wertelecki, W.: A Regional Genetics Program in Alabama with Emphasis on Education and Clinicians - Achievements and Experience. In: Medical Genetics and Society. Eds., Fujiki, N., Bulyzhenkov, V., Bankowski, Z., Kugler Publications, Amsterdam/New York, (1991).
  10. Wertelecki, W.: Diagnosis of NF-2. In: Neurofibromatosis 2. Eds., Cohen, B.R. Korf, B.H., Pugh, J.N., The National Neurofibromatosis Foundation, Inc., New York, NY (1992).
  11. Wertelecki, W.: Clinical Dermatoglyphics. In: Human Malformations and Related Anomalies, Eds., Stevenson, R.E., Editor. Oxford University Press, Inc. (1993).
  12. Wertelecki W.: Congenital Malformations in Rivne, Ukraine. 119–138. In: Crisis Without End: The Medical and Ecological Consequences of the Fukushima Nuclear Catastrophe. Helen Caldicott, editor. New Press, The, Oct 21, 304 pages (2014).

Further listing omitted.

Current special projects

Among others:

Distant Learning Modules

Sustenance of Contents in Dedicated Websites

References

  1. ↑ Niсeto S. Loizaga, M.D.
  2. ↑ Alexis Hartmann
  3. ↑ Holt, S B (December 1, 1976). "Harold Cummins (1894--1976)". Journal of Medical Genetics. 13 (6): 540. doi:10.1136/jmg.13.6.540. PMC   1013492 . PMID   798032.
  4. ↑ "University of South Alabama Press Release". www.southalabama.edu. Retrieved 2021-05-20.
  5. ↑ "Wertelecki w - Search Results - PubMed".
  6. ↑ "About SERGG". sergg.org. Retrieved 2021-05-20.
  7. ↑ "- FEDERAL RECOGNITION AND ACKNOWLEDGMENT PROCESS BY THE BUREAU OF INDIAN AFFAIRS". www.govinfo.gov. Retrieved 2021-05-20.
  8. ↑ "FEDERAL RECOGNITION AND ACKNOWLEDGMENT PROCESS BY THE BUREAU OF INDIAN AFFAIRS. House Hearing, 108 Congress. Second Session. Wednesday, March 31, 2004" (PDF).
  9. 1 2 States, United; Regulation, United States Congress Senate Committee on Environment and Public Works Subcommittee on Nuclear (1992). Effects of the Accident at the Chernobyl Nuclear Powerplant: Hearing Before the Subcommittee on Nuclear Regulation of the Committee on Environment and Public Works, United States Senate, One Hundred Second Congress, Second Session, July 22, 1992. U.S. Government Printing Office. ISBN   978-0-16-039183-5.
  10. 1 2 Wertelecki, Wladimir (2006). "Birth defects surveillance in Ukraine: a process". Journal of Applied Genetics. 47 (2): 143–149. doi:10.1007/BF03194614. ISSN   1234-1983. PMID   16682756. S2CID   27323393.
  11. 1 2 Wertelecki, W. (August 1989). "Of dreaming on solid grounds and silent triumphs of one man: a story about Joseph Warkany". American Journal of Medical Genetics. 33 (4): 522–536. doi:10.1002/ajmg.1320330424. ISSN   0148-7299. PMID   2688418.
  12. 1 2 Wertelecki, Wladimir (2020-07-15). "Josef Warkany's gestation of the teratology society". Birth Defects Research. 112 (12): 885–889. doi:10.1002/bdr2.1684. ISSN   2472-1727. PMID   32686352.
  13. ↑ maneus muscle
  14. ↑ Kim, Alexander Youngjoon; Bodurtha, Joann Norma (2019-12-01). "Dysmorphology" . Pediatrics in Review. 40 (12): 609–618. doi:10.1542/pir.2018-0331. ISSN   0191-9601. PMID   31792044. S2CID   219541461.
  15. ↑ Dr. Virgilio G. Foglia
  16. 1 2 Foglia, V. G.; Fernandez-Collazo, E. L.; Wesely, O. R.; Wertelecki, W.; Granillo, R. (August 1961). "[Disorders of reproduction in the diabetic male rat]". Revista de la Sociedad Argentina de Biologia. 37: 127–133. ISSN   0037-8380. PMID   13893774.
  17. ↑ "Bernardo Houssay – Facts". NobelPrize.org. Retrieved 2025-04-14.
  18. ↑ Loizaga, Niceto S. (December 1942). "De la psitacosis, enfermedad humana producida por el virus de un morbo aviario". El Hornero. 008 (2): 232–246. doi:10.56178/eh.v8i2.1405. hdl: 20.500.12110/hornero_v008_n02_p232 .
  19. ↑ Semiology
  20. ↑ HARTMANN, ALEXIS F. (1935-09-01). "Treatment of Severe Diabetic Acidosis" . Archives of Internal Medicine. 56 (3): 413–434. doi:10.1001/archinte.1935.00170010001001. ISSN   0730-188X.
  21. 1 2 KENNEDY, JOSEPH L., JR.; WERTELECKI, WLADIMIR; GATES, LORRAINE; SPERRY, BARBARA P.; CASS, VICTORIA M. (1967-01-01). "The Early Treatment of Phenylketonuria" . American Journal of Diseases of Children. 113 (1): 16–21. doi:10.1001/archpedi.1967.02090160066004. ISSN   0002-922X. PMID   6016173.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  22. ↑ Wertelecki, W (1967). A Computer Program for Gathering Family History. Eighth IBM Medical Symposium. p. 165.
  23. ↑ Niswander, J. D.; Wertelecki, W. (1973-05-12). "Congenital malformation among offspring of epileptic women". Lancet. 1 (7811): 1062. doi:10.1016/s0140-6736(73)90699-5. ISSN   0140-6736. PMID   4122140.
  24. 1 2 Wertelecki, Wladimir; Schindler, Anne M.; Gerald, Park S. (May 1967). "26 Deletion of Chromosome No. 18 (Long Arm). A New Syndrome". Pediatric Research. 1 (3): 207. doi: 10.1203/00006450-196705000-00033 . ISSN   1530-0447.
  25. 1 2 3 Wertelecki, W.; Schindler, A. M.; Gerald, P. S. (1966-09-17). "Partial Deletion of Chromosome 18" . The Lancet. 288 (7464): 641. doi:10.1016/S0140-6736(66)91964-7. ISSN   0140-6736.
  26. ↑ Miller, Robert W. (1966-07-14). "Relation between Cancer and Congenital Defects in Man" . New England Journal of Medicine. 275 (2): 87–93. doi:10.1056/NEJM196607142750208. ISSN   0028-4793. PMID   5327812.
  27. ↑ "Medical Terminology, Etymology, Mythology, Fine Arts | Pandora Word Box". www.pandorawordbox.com. Retrieved 2025-04-14.
  28. 1 2 Plato, Chris C.; Wertelecki, Wladimir; Gerald, Park S.; Niswander, Jerry D. (1971). "Dermatoglyphics in the 18q-Syndrome". Pediatric Research. 5 (2): 64–69. doi:10.1203/00006450-197102000-00003. ISSN   1530-0447.
  29. ↑ Tagwireyi, D.; Ball, D. E.; Loga, P. J.; Moyo, S. (2000-12-01). "Cantharidin poisoning due to "Blister beetle" ingestion" . Toxicon. 38 (12): 1865–1869. Bibcode:2000Txcn...38.1865T. doi:10.1016/S0041-0101(00)00093-3. ISSN   0041-0101. PMID   10858524.
  30. ↑ Wertelecki, Wladimir; Gerald, Park S. (1971). "Clinical and chromosomal studies of the 18q-syndrome" . The Journal of Pediatrics. 78 (1): 44–52. doi:10.1016/S0022-3476(71)80262-7. PMID   5539084.
  31. ↑ Wertelecki, Wladimir; Graham, JOHN M. Jr; Sergovich, Fred R. (January 1976). "The Clinical Syndrome of Triploidy". Obstetrics & Gynecology. 47 (1): 69–76. ISSN   0029-7844. PMID   1246396.
  32. ↑ Blackburn, W. R.; Miller, W. P.; Superneau, D. W.; Cooley, N. R.; Zellweger, H.; Wertelecki, W. (1982). "Comparative studies of infants with mosaic and complete triploidy: an analysis of 55 cases". Birth Defects Original Article Series. 18 (3B): 251–274. ISSN   0547-6844. PMID   6753965.
  33. ↑ Wertelecki, Wladimir; Smith, Lynne T.; Byers, Peter (1992). "Initial observations of human dermatosparaxis: Ehlers-Danlos syndrome type VIIC" . The Journal of Pediatrics. 121 (4): 558–564. doi:10.1016/S0022-3476(05)81144-8. PMID   1403389.
  34. ↑ Smith, L. T.; Wertelecki, W.; Milstone, L. M.; Petty, E. M.; Seashore, M. R.; Braverman, I. M.; Jenkins, T. G.; Byers, P. H. (1992). "Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen". American Journal of Human Genetics. 51 (2): 235–244. ISSN   0002-9297. PMC   1682688 . PMID   1642226.
  35. ↑ Colige, A.; Sieron, A. L.; Li, S. W.; Schwarze, U.; Petty, E.; Wertelecki, W.; Wilcox, W.; Krakow, D.; Cohn, D. H.; Reardon, W.; Byers, P. H.; Lapière, C. M.; Prockop, D. J.; Nusgens, B. V. (1999). "Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene". American Journal of Human Genetics. 65 (2): 308–317. doi:10.1086/302504. ISSN   0002-9297. PMC   1377929 . PMID   10417273.
  36. ↑ Superneau, Duane; Wertelecki, Wladimir; Zellweger, Hans; Opitz, John M.; Reynolds, James F. (1985). "The Marinesco-Sjögren syndrome described a quarter of a century before marinesco" . American Journal of Medical Genetics. 22 (3): 647–648. doi:10.1002/ajmg.1320220331. ISSN   0148-7299. PMID   3904448.
  37. ↑ Superneau, D.; Wertelecki, W.; Zellweger, H. (1985). "The Marinesco-Sjögren syndrome described a quarter of a century before Marinesco". American Journal of Medical Genetics. 22 (3): 647–648. doi:10.1002/ajmg.1320220331. ISSN   0148-7299. PMID   3904448.
  38. ↑ Superneau, D. W.; Wertelecki, W.; Zellweger, H.; Bastian, F. (1987). "Myopathy in Marinesco-Sjogren syndrome". European Neurology. 26 (1): 8–16. doi:10.1159/000116305. ISSN   0014-3022. PMID   3469098.
  39. ↑ Georgy, B. A.; Snow, R. D.; Brogdon, B. G.; Wertelecki, W. (1998). "Neuroradiologic findings in Marinesco-Sjögren syndrome". AJNR. American Journal of Neuroradiology. 19 (2): 281–283. ISSN   0195-6108. PMC   8338194 . PMID   9504478.
  40. ↑ Ezgu, F.; Krejci, P.; Li, S.; de Sousa, C.; Graham, J. M.; Hansmann, I.; He, W.; Porpora, K.; Wand, D.; Wertelecki, W.; Schneider, A.; Wilcox, W. R. (2014). "Phenotype-genotype correlations in patients with Marinesco-Sjögren syndrome". Clinical Genetics. 86 (1): 74–84. doi:10.1111/cge.12230. ISSN   1399-0004. PMID   23829326.
  41. ↑ Wertelecki, W.; Superneau, D. W.; Blackburn, W. R.; Varakis, J. N. (1982). "Neurofibromatosis, skin hemangiomas, and arterial disease". Birth Defects Original Article Series. 18 (3B): 29–41. ISSN   0547-6844. PMID   6814548.
  42. ↑ Wertelecki, W.; Iinuma, K.; Bentley, H. P. (1985). "Non-neural malignancy complicating neurofibromatosis in two relatives". Cancer Genetics and Cytogenetics. 18 (1): 87–89. doi:10.1016/0165-4608(85)90043-3. ISSN   0165-4608. PMID   3928141.
  43. ↑ Rouleau, G. A.; Wertelecki, W.; Haines, J. L.; Hobbs, W. J.; Trofatter, J. A.; Seizinger, B. R.; Martuza, R. L.; Superneau, D. W.; Conneally, P. M.; Gusella, J. F. (1987-09-17). "Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22". Nature. 329 (6136): 246–248. Bibcode:1987Natur.329..246R. doi:10.1038/329246a0. ISSN   0028-0836. PMID   2888021.
  44. ↑ Wertelecki, W.; Rouleau, G. A.; Superneau, D. W.; Forehand, L. W.; Williams, J. P.; Haines, J. L.; Gusella, J. F. (1988-08-04). "Neurofibromatosis 2: clinical and DNA linkage studies of a large kindred". The New England Journal of Medicine. 319 (5): 278–283. doi:10.1056/NEJM198808043190505. ISSN   0028-4793. PMID   3134615.
  45. ↑ Wertelecki, W.; Superneau, D. W.; Forehand, L. W.; Hoff, C. J. (1988). "Angiomas and von Recklinghausen neurofibromatosis". Neurofibromatosis. 1 (3): 137–145. ISSN   1010-5662. PMID   3152460.
  46. ↑ Rouleau, G. A.; Seizinger, B. R.; Wertelecki, W.; Haines, J. L.; Superneau, D. W.; Martuza, R. L.; Gusella, J. F. (1990). "Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on chromosome 22". American Journal of Human Genetics. 46 (2): 323–328. ISSN   0002-9297. PMC   1684964 . PMID   2105641.
  47. ↑ MacCollin, M.; Mohney, T.; Trofatter, J.; Wertelecki, W.; Ramesh, V.; Gusella, J. (1993-11-17). "DNA diagnosis of neurofibromatosis 2. Altered coding sequence of the merlin tumor suppressor in an extended pedigree". JAMA. 270 (19): 2316–2320. doi:10.1001/jama.270.19.2316. ISSN   0098-7484. PMID   8230593.
  48. ↑ Ruttledge, M. H.; Narod, S. A.; Dumanski, J. P.; Parry, D. M.; Eldridge, R.; Wertelecki, W.; Parboosingh, J.; Faucher, M. C.; Lenoir, G. M.; Collins, V. P. (1993). "Presymptomatic diagnosis for neurofibromatosis 2 with chromosome 22 markers". Neurology. 43 (9): 1753–1760. doi:10.1212/wnl.43.9.1753. ISSN   0028-3878. PMID   8414026.
  49. 1 2 Wertelecki, Wladimir (2010-04-01). "Malformations in a Chornobyl-Impacted Region" . Pediatrics. 125 (4): e836 –e843. doi:10.1542/peds.2009-2219. ISSN   0031-4005. PMID   20308207. S2CID   2814328.
  50. ↑ Wertelecki, Wladimir (2021). "Chornobyl radiation—congenital anomalies: A persisting dilemma". Congenital Anomalies. 61 (1): 9–13. doi:10.1111/cga.12388. PMID   33405251.
  51. ↑ Wertelecki, Wladimir; Yevtushok, Lyubov; Kuznietsov, Illia; Komov, Oleksandr; Lapchenko, Serhii; Akhmedzanova, Diana; Ostapchuk, Lyubov (2018-09-01). "Chornobyl, radiation, neural tube defects, and microcephaly" . European Journal of Medical Genetics. 61 (9): 556–563. doi:10.1016/j.ejmg.2018.06.005. ISSN   1769-7212. PMID   29908351. S2CID   49271245.
  52. 1 2 "Prenatal Alcohol Exposure in Ukraine". Center for Better Beginnings. Retrieved 2025-04-14.
  53. ↑ Dancause, Kelsey Needham; Yevtushok, Lyubov; Lapchenko, Serhiy; Shumlyansky, Ihor; Shevchenko, Genadiy; Wertelecki, Wladimir; Garruto, Ralph M. (2010). "Chronic radiation exposure in the Rivne-Polissia region of Ukraine: implications for birth defects". American Journal of Human Biology. 22 (5): 667–674. doi:10.1002/ajhb.21063. ISSN   1520-6300. PMID   20737614.
  54. ↑ Wertelecki, Wladimir; Yevtushok, Lyubov; Zymak-Zakutnia, Natalia; Wang, Bin; Sosyniuk, Zoriana; Lapchenko, Serhiy; Hobart, Holly H. (2014). "Blastopathies and microcephaly in a Chornobyl impacted region of Ukraine". Congenital Anomalies. 54 (3): 125–149. doi:10.1111/cga.12051. ISSN   1741-4520. PMC   4233949 . PMID   24666273.
  55. ↑ Foreign Member
  56. ↑ "Список Почесних Докторів Львівського національного медичного університету імені Данила Галицького", Вікіпедія (in Ukrainian), 2017-05-10, retrieved 2021-05-25
  57. ↑ Distinguished Service Award
  58. ↑ The Teratology Society
  59. ↑ National Academy of Sciences of Ukraine
  60. ↑ Search Results for author Wertelecki W on PubMed .
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