XAB2

XAB2
Identifiers
Aliases	XAB2 , HCNP, HCRN, NTC90, SYF1, XPA binding protein 2
External IDs	OMIM: 610850; MGI: 1914689; HomoloGene: 5738; GeneCards: XAB2; OMA:XAB2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 7,619,525 bp [1] End 7,629,545 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 A1.1|8 1.92 cM Start 3,658,421 bp [2] End 3,671,316 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary granulocyte right ovary skin of leg body of uterus right uterine tube canal of the cervix right lobe of thyroid gland left lobe of thyroid gland skin of abdomen Top expressed in gastrula submandibular gland internal carotid artery external carotid artery Rostral migratory stream Gonadal ridge vestibular membrane of cochlear duct maxillary prominence epiblast granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component catalytic step 2 spliceosome membrane nucleoplasm spliceosomal complex nucleus Prp19 complex prespliceosome catalytic step 1 spliceosome post-mRNA release spliceosomal complex U2-type catalytic step 2 spliceosome Biological process RNA processing mRNA processing transcription, DNA-templated cellular response to DNA damage stimulus RNA splicing cerebral cortex development transcription-coupled nucleotide-excision repair blastocyst development DNA repair mRNA splicing, via spliceosome generation of catalytic spliceosome for first transesterification step Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56949 67439 Ensembl ENSG00000076924 ENSMUSG00000019470 UniProt Q9HCS7 Q9DCD2 RefSeq (mRNA) NM_020196 NM_026156 RefSeq (protein) NP_064581 NP_080432 Location (UCSC) Chr 19: 7.62 – 7.63 Mb Chr 8: 3.66 – 3.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene. ^{[5] [6]}

Interactions

XAB2 has been shown to interact with ERCC8 ^[5] and XPA. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000076924 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019470 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi: 10.1074/jbc.M004936200 . hdl: 1765/3168 . PMID   10944529.
6. "Entrez Gene: XAB2 XPA binding protein 2".

Further reading

• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID   10574461.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4) S1355838202021088: 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.