XAB2

XAB2
Identifiers
Aliases	XAB2 , HCNP, HCRN, NTC90, SYF1, XPA binding protein 2
External IDs	OMIM: 610850 MGI: 1914689 HomoloGene: 5738 GeneCards: XAB2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,629,545 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,671,316 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; canal of the cervix; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; skin of abdomen; ; body of stomach; ; gastric mucosa; ; left uterine tube; ; tibial nerve; ; popliteal artery;
	Top expressed in
	submandibular gland; ; internal carotid artery; ; external carotid artery; ; maxillary prominence; ; primitive streak; ; hair follicle; ; supraoptic nucleus; ; somite; ; ascending aorta; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	catalytic step 2 spliceosome ; membrane ; nucleoplasm ; spliceosomal complex ; nucleus ; Prp19 complex ; prespliceosome ; catalytic step 1 spliceosome ; post-mRNA release spliceosomal complex ; U2-type catalytic step 2 spliceosome ;
Biological process	RNA processing ; mRNA processing ; transcription, DNA-templated ; cellular response to DNA damage stimulus ; RNA splicing ; cerebral cortex development ; transcription-coupled nucleotide-excision repair ; blastocyst development ; DNA repair ; mRNA splicing, via spliceosome ; generation of catalytic spliceosome for first transesterification step ;
	Sources:Amigo / QuickGO
Orthologs
	56949
	67439
	ENSG00000076924
	ENSMUSG00000019470
	Q9HCS7
	Q9DCD2
	NM_020196
	NM_026156
	NP_064581
	NP_080432
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 06, 2024

Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene.^[5]^[6]

Interactions

XAB2 has been shown to interact with ERCC8 ^[5] and XPA.^[5]

Related Research Articles

5'-3' Exoribonuclease 2 (XRN2) also known as Dhm1-like protein is an exoribonuclease enzyme that in humans is encoded by the XRN2 gene.

DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene.

General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene.

DNA excision repair protein ERCC-8 is a protein that in humans is encoded by the ERCC8 gene.

DNA-directed RNA polymerases I and III subunit RPAC1 is a protein that in humans is encoded by the POLR1C gene.

Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.

Zinc transporter SLC39A7 (ZIP7), also known as solute carrier family 39 member 7, is a protein that in humans is encoded by the SLC39A7 gene. Its fruit fly orthologue is Catsup.

MMS19 nucleotide excision repair protein homolog is a protein that in humans is encoded by the MMS19 gene.

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

Zinc finger CCCH domain-containing protein 11A is a protein that in humans is encoded by the ZC3H11A gene. ZC3H11A is a part of the transcription export (TREX) complex and plays a role in exporting of mRNAs from nucleus to cytoplasm. It is considered as stress-induced nuclear protein and maintains mRNAs exporting when the cells are under stress. Loss of functioning of ZC3H11A gene in HeLa cells results in abortion of the replication of nuclear replicating viruses but not cytoplasmic replicating viruses. It is discovered that ZC3H11A is significant for viability and metabolic regulation of mouse embryo

Probable RNA-binding protein 23 is a protein that in humans is encoded by the RBM23 gene.

Synapse-associated protein 1 is a protein that in humans is encoded by the SYAP1 gene.

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.

Arginine vasopressin-induced protein 1 is a protein that in humans is encoded by the AVPI1 gene.

Zinc finger protein 239 is a protein that in humans is encoded by the ZNF239 gene.

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.

RNA polymerase II associated protein 2, also known as RPAP2, is a human gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000076924 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019470 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi: 10.1074/jbc.M004936200 . hdl: 1765/3168 . PMID 10944529.
↑ "Entrez Gene: XAB2 XPA binding protein 2".

Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID 10574461.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266 . PMID 11991638.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC 524842 . PMID 15498874.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000076924 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019470 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10944529-5] 1 2 3 Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi: 10.1074/jbc.M004936200 . hdl: 1765/3168 . PMID 10944529.

[entrez-6] "Entrez Gene: XAB2 XPA binding protein 2".

[1]

[2]

[3]

[4]

[5]

[6]

XAB2

Contents

Interactions

Related Research Articles

References

Further reading