ZFYVE1

ZFYVE1
Identifiers
Aliases	ZFYVE1 , DFCP1, PPP1R172, SR3, TAFF1, ZNFN2A1, zinc finger FYVE-type containing 1
External IDs	OMIM: 605471; MGI: 3026685; HomoloGene: 10945; GeneCards: ZFYVE1; OMA:ZFYVE1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.2 Start 72,969,451 bp [1] End 73,027,131 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 D1 Start 83,593,332 bp [2] End 83,643,996 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle middle temporal gyrus amniotic fluid mucosa of ileum pancreatic epithelial cell saphenous vein deltoid muscle endothelial cell pars compacta lateral nuclear group of thalamus Top expressed in spermatid seminiferous tubule granulocyte muscle of thigh neural layer of retina hand ventricular zone left lobe of liver spermatocyte decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding 1-phosphatidylinositol binding protein binding phosphatidylinositol-3,4,5-trisphosphate binding metal ion binding phosphatidylinositol-3,4-bisphosphate binding Cellular component perinuclear region of cytoplasm autophagosome mitochondria associated membranes Golgi stack Golgi apparatus extrinsic component of omegasome membrane endoplasmic reticulum membrane phagophore assembly site omegasome Biological process negative regulation of phosphatase activity cellular response to starvation macroautophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53349 217695 Ensembl ENSG00000165861 ENSMUSG00000042628 UniProt Q9HBF4 Q810J8 RefSeq (mRNA) NM_001281734 NM_001281735 NM_021260 NM_178441 NM_183154 NM_001359166 NM_001359167 NM_001359168 RefSeq (protein) NP_001268663 NP_001268664 NP_067083 NP_848535 NP_898977 NP_001346095 NP_001346096 NP_001346097 Location (UCSC) Chr 14: 72.97 – 73.03 Mb Chr 12: 83.59 – 83.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ZFYVE1 gene. ^{[5] [6] [7]}

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution. Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000165861 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042628 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW (Nov 2000). "Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library". Gene. 255 (2): 195–203. doi:10.1016/S0378-1119(00)00303-6. PMID   11024279.
6. Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM (Mar 2001). "Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi". Biochem J. 355 (Pt 1): 113–21. doi:10.1042/0264-6021:3550113. PMC   1221718 . PMID   11256955.
7. "Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1".

Further reading

• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID   10997877.
• Ridley SH, Ktistakis N, Davidson K, et al. (2002). "FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments" (PDF). J. Cell Sci. 114 (Pt 22): 3991–4000. doi:10.1242/jcs.114.22.3991. PMID   11739631.
• Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell. 9 (1): 95–108. doi: 10.1016/S1097-2765(02)00434-3 . PMID   11804589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi: 10.1038/nature01348 . PMID   12508121.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.