Terminal nerve

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Cranial nerve zero
Lawrence 1960 1.3.png
Left The terminal nerve as it is shown on the ventral side of a dog-fish brain. (Topmost label)
Details
Identifiers
Latin nervus terminalis
TA98 A14.2.01.002
TA2 6179
FMA 76749
Anatomical terminology

The terminal nerve, also known as cranial nerve 0 or simply as CN 0, is a nerve that was not included in the seminal classification of the cranial nerves as CN I through CN XII but is now generally classified as a cranial nerve. It was discovered by German scientist Gustav Fritsch in 1878 in the brains of sharks. It was first found in humans in 1913. [1] A 1990 study has indicated that the terminal nerve is a common finding in the adult human brain. [2] [3] The nerve has been called unofficially by other names, including cranial nerve XIII, zero nerve, nerve N, [4] and NT. [5]

Contents

Structure

The original images (1878) of Fritsch's dogfish shark brain showing the nerve marked by an asterisk Fritsch dogfish shark brain.png
The original images (1878) of Fritsch's dogfish shark brain showing the nerve marked by an asterisk

The terminal nerve appears just anterior of the other cranial nerves bilaterally as a microscopic plexus of unmyelinated peripheral nerve fascicles in the subarachnoid space covering the gyrus rectus. This plexus appears near the cribriform plate and travels posteriorly toward the olfactory trigone, medial olfactory gyrus, and lamina terminalis. [2]

The nerve is often overlooked in autopsies because it is unusually thin for a cranial nerve, and is often torn out upon exposing the brain. [4] Careful dissection is necessary to visualize the nerve. Its purpose and mechanism of function is still open to debate; consequently, nerve zero is often not mentioned in anatomy textbooks. [1]

Development

The zebrafish was used as a developmental model in research from 2004. [6]

The connections between the terminal nerve and the olfactory system have been extensively studied in human embryos. It was found to enter the brain at stages 17 and 18 from olfactory origins. [7]

Function

Although very close to [8] (and often confused for a branch of) the olfactory nerve, the terminal nerve is not connected to the olfactory bulb, where smells are analyzed. This fact suggests that the nerve is either vestigial or may be related to the sensing of pheromones. This hypothesis is further supported by the fact that the terminal nerve projects to the medial and lateral septal nuclei and the preoptic areas, all of which are involved in regulating sexual behavior in mammals, [1] as well as a 1987 study finding that mating in hamsters is reduced when the terminal nerve is severed. [9]

Additional images

See also

Related Research Articles

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<span class="mw-page-title-main">Olfactory nerve</span> Cranial nerve I, for smelling

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<span class="mw-page-title-main">Abducens nerve</span> Cranial nerve VI, for eye movements

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Articles related to anatomy include:

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The oculomotor nerve, also known as the third cranial nerve, cranial nerve III, or simply CN III, is a cranial nerve that enters the orbit through the superior orbital fissure and innervates extraocular muscles that enable most movements of the eye and that raise the eyelid. The nerve also contains fibers that innervate the intrinsic eye muscles that enable pupillary constriction and accommodation. The oculomotor nerve is derived from the basal plate of the embryonic midbrain. Cranial nerves IV and VI also participate in control of eye movement.

<span class="mw-page-title-main">Nasal cavity</span> Large, air-filled space above and behind the nose in the middle of the face

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<span class="mw-page-title-main">Orbit (anatomy)</span> Cavity or socket of the skull in which the eye and its appendages are situated

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<span class="mw-page-title-main">Sixth nerve palsy</span> Medical condition

Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve VI, which is responsible for causing contraction of the lateral rectus muscle to abduct the eye. The inability of an eye to turn outward, results in a convergent strabismus or esotropia of which the primary symptom is diplopia in which the two images appear side-by-side. Thus, the diplopia is horizontal and worse in the distance. Diplopia is also increased on looking to the affected side and is partly caused by overaction of the medial rectus on the unaffected side as it tries to provide the extra innervation to the affected lateral rectus. These two muscles are synergists or "yoke muscles" as both attempt to move the eye over to the left or right. The condition is commonly unilateral but can also occur bilaterally.

<span class="mw-page-title-main">Uncus</span> Structure in the brain

The uncus is an anterior extremity of the parahippocampal gyrus. It is separated from the apex of the temporal lobe by a slight fissure called the incisura temporalis.

<span class="mw-page-title-main">Olfactory tract</span> Part of the olfactory system

The olfactory tract is a bilateral bundle of afferent nerve fibers from the mitral and tufted cells of the olfactory bulb that connects to several target regions in the brain, including the piriform cortex, amygdala, and entorhinal cortex. It is a narrow white band, triangular on coronal section, the apex being directed upward.

<span class="mw-page-title-main">Straight gyrus</span>

The portion of the inferior frontal lobe immediately adjacent to the longitudinal fissure is named the straight gyrus,(or gyrus rectus) and is continuous with the superior frontal gyrus on the medial surface.

<span class="mw-page-title-main">Outline of human anatomy</span> Overview of and topical guide to human anatomy

The following outline is provided as an overview of and topical guide to human anatomy:

<span class="mw-page-title-main">Olfactory foramina</span>

The olfactory foramina, also known as the cribriform foramina, is the grouping of holes located on the cribriform plate. The cribriform plate forms the roof of the nasal cavity, and the olfactory foramina are in the two depressions lateral to the median blade of the cribriform plate called the crista galli. There is a pair of olfactory bulbs of the brain that rest in these two depressions. These holes that make up the olfactory foramina allow passage for about 20 bundles of nerve fibers that make up the olfactory nerve, also known as Cranial Nerve I (CNI), from the nasal cavity to meet with the olfactory bulbs. Therefore, the olfactory foramina are necessary for the human sense of smell. These foramina vary in size and number with age.

<span class="mw-page-title-main">Outline of the human nervous system</span> Overview of and topical guide to the human nervous system

The following diagram is provided as an overview of and topical guide to the human nervous system:

References

  1. 1 2 3 Fields, R. Douglas (2007). "Sex and the Secret Nerve". Scientific American Mind. 18: 20–7. doi:10.1038/scientificamericanmind0207-20.
  2. 1 2 Fuller GN, Burger PC (1990). "Nervus terminalis (cranial nerve zero) in the adult human". Clinical Neuropathology. 9 (6): 279–83. PMID   2286018. The presence of an additional cranial nerve (the nervus terminalis or cranial nerve zero) is well documented in many non-human vertebrate species. However, its existence in the adult human has been disputed. The present study focused on the structure and incidence of this nerve in the adult human brain. The nerve was examined post-mortem in 10 adult brains using dissection microscopy, light microscopy, transmission electron microscopy, and immuno­histo­chemistry. In all specimens, the nervus terminalis was identified bilaterally as a microscopic plexus of unmyelinated peripheral nerve fascicles in the subarachnoid space covering the gyrus rectus of the orbital surface of the frontal lobes. The plexus appeared in the region of the cribriform plate of the ethmoid and coursed posteriorly to the vicinity of the olfactory trigone, medial olfactory gyrus, and lamina terminalis. We conclude that the terminal nerve is a common finding in the adult human brain, confirming early light microscopic reports.
  3. Berman, Laura (March 25, 2008). "Scientists discover secret sex nerve". TODAY.com . Archived from the original on June 27, 2019. Retrieved June 27, 2019.
  4. 1 2 Bordoni, Bruno; Zanier, Emiliano (March 13, 2013). "Cranial nerves XIII and XIV: nerves in the shadows". Journal of Multidisciplinary Healthcare. Dove Medical Press. 6: 87–91. doi: 10.2147/JMDH.S39132 . eISSN   1178-2390. ISSN   1178-2390. OCLC   319595339. PMC   3601045 . PMID   23516138.
  5. Vilensky, JA (January 2014). "The neglected cranial nerve: nervus terminalis (cranial nerve N)". Clinical Anatomy. 27 (1): 46–53. doi:10.1002/ca.22130. PMID   22836597. S2CID   21454488.
  6. Whitlock KE (September 2004). "Development of the nervus terminalis: origin and migration". Microscopy Research and Technique. 65 (1–2): 2–12. doi: 10.1002/jemt.20094 . PMID   15570589. S2CID   8736656.
  7. Müller F, O'Rahilly R (2004). "Olfactory structures in staged human embryos". Cells Tissues Organs. 178 (2): 93–116. doi:10.1159/000081720. PMID   15604533. S2CID   43056268.
  8. Von Bartheld CS (September 2004). "The terminal nerve and its relation with extrabulbar "olfactory" projections: lessons from lampreys and lungfishes". Microscopy Research and Technique. 65 (1–2): 13–24. doi: 10.1002/jemt.20095 . PMID   15570592.
  9. Wirsig, Celeste (11 August 1987). "Terminal nerve damage impairs the mating behavior of the male hamster". Brain Research. 417 (2): 293–303. doi:10.1016/0006-8993(87)90454-9. PMID   3308003. S2CID   33371658.