2 February | 1 | Wigan Warriors | A | DW Stadium | W | 24–8 | McGillvary (3), Ferres, Grix | Brough 1/4 | 16,240 | BBC |
23 February | 2 | Hull Kingston Rovers | H | John Smith's Stadium | D | 24–24 | Brough, Robinson (2), Wood | Brough 4/4 | 7,180 | BBC |
28 February | 3 | Widnes Vikings | A | Halton Stadium | L | 20–22 | McGillvary, Cudjoe, Crabtree | Brough 4/5 | 5,577 | SL |
7 March | 4 | Leeds Rhinos | H | John Smith's Stadium | D | 12–12 | Broughton, Wardle | Brough 2/4 | 8,759 | SL |
16 March | 5 | Bradford Bulls | A | Odsal Stadium | W | 66–18 | Grix (2), Wardle (2), Lawrence, Robinson, Chan, Ta'ai (2), McGillvary (2), Ferres | Brough 9/12 | 6,781 | SL |
22 March | 6 | Catalans Dragons | A | Stade Gilbert Brutus | L | 14–30 | Grix, Ferres, Broughton | Brough 1/3 | 6,600 | SL |
30 March | 7 | Warrington Wolves | H | John Smith's Stadium | L | 14–33 | Grix, Broughton | Brough 3/3 | 7,068 | SL |
10 April | 8 | Hull F.C. | A | KC Stadium | L | 6–30 | Broughton | Brough 1/1 | 9,515 | SL |
18 April | 9 | Salford Red Devils | A | AJ Bell Stadium | W | 42–22 | Lunt, Murphy (3), Brough, McGillvary, Bailey | Brough 7/7 | 5,068 | SL |
21 April | 10 | Wakefield Trinity Wildcats | H | John Smith's Stadium | W | 36–16 | Broughton, Lawrence, Ta'ai, Cudjoe, Chan, Lunt | Brough 6/6 | 5,487 | SL |
4 May | 11 | Castleford Tigers | H | John Smith's Stadium | W | 29–28 | Wardle, Cudjoe, McGillvary, Grix, Murphy | Brough 4/5, Brough 1 DG | 7,195 | SL |
10 May | 12 | London Broncos | A | The Hive | W | 30–16 | Lunt, Ta'ai (2), Mullally, Cudjoe | Brough 5/5 | 1,035 | SL |
18 May | 13 | Bradford Bulls | N | Etihad Stadium | W | 54–16 | Wardle, Lunt, Robinson, Broughton, Brough, Grix, Ta'ai, Mullally, Patrick | Brough 9/9 | | SL |
23 May | 14 | St. Helens | A | Langtree Park | L | 22–41 | Patrick, Blackmore (2), Ferres | Brough 3/4 | 10,218 | SL |
29 May | 15 | Wigan Warriors | H | John Smith's Stadium | W | 31–22 | Murphy, Lunt, Wardle (2), McGillvary | Brough 5/5, Brough 1 DG | 6,106 | SL |
12 June | 16 | Leeds Rhinos | A | Headingley Stadium | W | 24–22 | | | | RLP |
21 June | 17 | London Broncos | H | John Smith's Stadium | W | 38–22 | | | | RLP |
26 June | 18 | Hull Kingston Rovers | A | KC Stadium | W | 26–22 | | | | RLP |
5 July | 19 | Salford Red Devils | H | John Smith's Stadium | L | 10–36 | | | | RLP |
11 July | 20 | Castleford Tigers | A | Mend-A-Hose Jungle | L | 30–44 | | | | RLP |
20 July | 21 | Bradford Bulls | H | John Smith's Stadium | W | 52–26 | | | | RLP |
27 July | 22 | Catalans Dragons | H | John Smith's Stadium | W | 38–16 | | | | RLP |
3 August | 23 | Wakefield Trinity Wildcats | A | Rapid Solicitors Stadium | W | 36–18 | | | | RLP |
17 August | 24 | Widnes Vikings | H | John Smith's Stadium | W | 28–14 | | | | RLP |
28 August | 25 | Warrington Wolves | A | Halliwell Jones Stadium | D | 24–24 | | | | RLP |
7 September | 26 | Hull F.C. | H | John Smith's Stadium | W | 38–28 | | | | RLP |
12 September | 27 | St Helens | H | John Smith's Stadium | W | 17–16 | | | | RLP |