2016 United States Elizabethkingia outbreak

Last updated
2016 United States Elizabethkingia anophelis outbreak
Wisconsin in United States.svg
Wisconsin, in red, the location of 63 confirmed cases as of June 16, 2016
DateNovember 1, 2015 (2015-11-01) — present
Location Wisconsin, western Michigan, and Illinois, United States [1] [2]
TypeDisease outbreak
Cause Elizabethkingia anophelis
Casualties
  • Cases / Deaths(as of June 16, 2016) [3] [2]
  • Wisconsin: 63 / 18
  • Michigan: 1 / 1
  • Illinois: 1 / 1
Deaths20 [3]

An outbreak of Elizabethkingia anophelis infections centered in Wisconsin [4] [5] is thought to have led to the death of at least 20 people in Wisconsin, Michigan, and Illinois. [6] [7] [1] [2]

History

As of March 2016, it was reported to be the largest outbreak of Elizabethkingia anophelis -caused disease investigated by the Centers for Disease Control and Prevention (CDC). [8]

Human infections by E. anophelis involve the bloodstream. [4] Signs and symptoms can include fever, shortness of breath, chills, and cellulitis. [4] Confirmation requires a laboratory test. [4]

Statewide surveillance of the situation in Wisconsin was organized on January 5, 2016. [9] Cases had been reported from Columbia, Dane, Dodge, Fond du Lac, Jefferson, Milwaukee, Ozaukee, Racine, Sauk, Sheboygan, Washington, Waukesha, and Winnebago Counties); Illinois; and western Michigan as of April 13, 2016. [9] [1]

Between November 1, 2015 and March 30, 2016, 62 cases of E. anophelis infections were reported to the Wisconsin Department of Health Services, Division of Public Health. [4]

The severity of the outbreak is reflected in a statement by the CDC that "the agency sees a handful of Elizabethkingia infections around the country each year, but the outbreaks rarely involve more than a couple of cases at a time. To have dozens of cases at once — and more than a third of them possibly fatal — is startling". [10]

Related Research Articles

<span class="mw-page-title-main">Anthrax</span> Infection caused by Bacillus anthracis bacteria

Anthrax is an infection caused by the bacterium Bacillus anthracis. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The skin form presents with a small blister with surrounding swelling that often turns into a painless ulcer with a black center. The inhalation form presents with fever, chest pain and shortness of breath. The intestinal form presents with diarrhea, abdominal pains, nausea and vomiting. The injection form presents with fever and an abscess at the site of drug injection.

<span class="mw-page-title-main">Shigellosis</span> Medical condition

Shigellosis is an infection of the intestines caused by Shigella bacteria. Symptoms generally start one to two days after exposure and include diarrhea, fever, abdominal pain, and feeling the need to pass stools even when the bowels are empty. The diarrhea may be bloody. Symptoms typically last five to seven days and it may take several months before bowel habits return entirely to normal. Complications can include reactive arthritis, sepsis, seizures, and hemolytic uremic syndrome.

<span class="mw-page-title-main">Whooping cough</span> Human disease caused by the bacteria Bordetella pertussis

Whooping cough, also known as pertussis or the 100-day cough, is a highly contagious, vaccine-preventable bacterial disease. Initial symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough, but these are followed by two or three months of severe coughing fits. Following a fit of coughing, a high-pitched whoop sound or gasp may occur as the person breathes in. The violent coughing may last for 10 or more weeks, hence the phrase "100-day cough". A person may cough so hard that they vomit, break ribs, or become very tired from the effort. Children less than one year old may have little or no cough and instead have periods where they cannot breathe. The time between infection and the onset of symptoms is usually seven to ten days. Disease may occur in those who have been vaccinated, but symptoms are typically milder.

<span class="mw-page-title-main">Hand, foot, and mouth disease</span> Common human disease caused by a group of viruses

Hand, foot, and mouth disease (HFMD) is a common infection caused by a group of enteroviruses. It typically begins with a fever and feeling generally unwell. This is followed a day or two later by flat discolored spots or bumps that may blister, on the hands, feet and mouth and occasionally buttocks and groin. Signs and symptoms normally appear 3–6 days after exposure to the virus. The rash generally resolves on its own in about a week. Fingernail and toenail loss may occur a few weeks later, but they will regrow with time.

<span class="mw-page-title-main">Listeriosis</span> Medical condition

Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although L. ivanovii and L. grayi have been reported in certain cases. Listeriosis can cause severe illness, including severe sepsis, meningitis, or encephalitis, sometimes resulting in lifelong harm and even death. Those at risk of severe illness are the elderly, fetuses, newborns and those who are immunocompromised. In pregnant women it may cause stillbirth or spontaneous abortion, and preterm birth is common. Listeriosis may cause mild, self-limiting gastroenteritis and fever in anyone.

The 2006 North American E. coli outbreak was an Escherichia coli O157:H7 outbreak from prepackaged spinach. The outbreak occurred in September 2006, and its origin was an Angus cattle ranch that had leased land to a spinach grower. At least 276 consumer illnesses and 3 deaths have been attributed as a result from the outbreak.

<span class="mw-page-title-main">Ehrlichiosis</span> Medical condition

Ehrlichiosis is a tick-borne bacterial infection, caused by bacteria of the family Anaplasmataceae, genera Ehrlichia and Anaplasma. These obligate intracellular bacteria infect and kill white blood cells.

<span class="mw-page-title-main">2011 United States listeriosis outbreak</span> Disease outbreak in the United States

The 2011 United States listeriosis outbreak was a widespread outbreak of Listeria monocytogenes food poisoning across 28 US states that resulted from contaminated cantaloupes linked to Jensen Farms of Holly, Colorado. As of the final report on August 27, 2012, there were 33 deaths and 147 total confirmed cases since the beginning of the first recorded case on July 31, 2011. It was the worst foodborne illness outbreak in the United States, measured by the number of deaths, since the Centers for Disease Control and Prevention began tracking outbreaks in the 1970s, or tied with the worst, an outbreak of listeria from cheese in 1985, depending on which CDC report is used.

<span class="mw-page-title-main">1976 Philadelphia Legionnaires' disease outbreak</span> First occasion of a cluster of a pneumonia cases later identified as Legionnaires disease

The 1976 Legionnaires disease outbreak, occurring in the late summer in Philadelphia, Pennsylvania, United States was the first occasion in which a cluster of a particular type of pneumonia cases were determined to be caused by the Legionella pneumophila bacteria.

The 2012 outbreak of Salmonella took place in 15 places worldwide with over 2,300 strains identified.

<span class="mw-page-title-main">2003 Midwest monkeypox outbreak</span> Outbreak of monkeypox in the United States

Beginning in May 2003, by July a total of 71 cases of human monkeypox were found in six Midwestern states including Wisconsin, Indiana (16), Illinois (12), Kansas (1), Missouri (2), and Ohio (1). The cause of the outbreak was traced to three species of African rodents imported from Ghana on April 9, 2003, into the United States by an exotic animal importer in Texas. These were shipped from Texas to an Illinois distributor, who housed them with prairie dogs, which then became infected.

<span class="mw-page-title-main">Legionnaires' disease</span> Legionellosis that is characterized by severe form of infection producing pneumonia

Legionnaires' disease is a form of atypical pneumonia caused by any species of Legionella bacteria, quite often Legionella pneumophila. Signs and symptoms include cough, shortness of breath, high fever, muscle pains, and headaches. Nausea, vomiting, and diarrhea may also occur. This often begins 2–10 days after exposure.

Elizabethkingia anophelis is a yellow-pigmented, rod-shaped, gram-negative bacterium in the Flavobacteriaceae family. Elizabethkingia is isolated from the midgut of Anopheles gambiae G3 mosquitoes reared in captivity. The genus Elizabethkingia, named for former US Centers for Disease Control and Prevention (CDC) microbiologist Elizabeth O. King, also includes E. meningoseptica which causes neonatal sepsis and infections in immunocompromised persons, E. endophytica, and E. miricola.

<span class="mw-page-title-main">Elizabeth O. King</span> American bacteriologist (1912–1966)

Elizabeth Osborne King was an American microbiologist who discovered and described bacteria of medical importance at the United States Centers for Disease Control and Prevention from the late 1940s through the early 1960s. A 1984 CDC manual dedication referred to King as "internationally known as an authority on a variety of unusual bacteria." The genera Kingella and Elizabethkingia and several species of bacteria are named to honor her for her pioneering work. King died of cancer on April 8, 1966, in Atlanta, where she is interred in Oakland Cemetery.

Elizabethkingia miricola is a species of bacterium isolated from condensation water in Space Station Mir, related to Elizabethkingia anophelis, the cause of the 2016 outbreak of Elizabethkingia anophelis human infections in Wisconsin that began in early November 2015. The genus name Elizabethkingia honors former United States Centers for Disease Control (CDC) microbiologist Elizabeth O. King, and the specific epithet is derived from combining the Russian name of the space station from which the bacterium was isolated, "Mir" meaning "peace," and the Latin "incola" meaning "inhabitant," yielding miricola, "inhabitant of the Mir space station."

Elizabethkingia is a genus of bacterium described in 2005, named after Elizabeth O. King, the discoverer of the type species. Before this genus being formed in 2005, many of the species of Elizabethkingia were classified in the Chryseobacterium genus. Elizabethkingia has been found in soil, rivers, and reservoirs worldwide.

<i>Candida auris</i> Species of fungus

Candida auris is a species of fungus that grows as yeast. It is one of the few species of the genus Candida which cause candidiasis in humans. Often, candidiasis is acquired in hospitals by patients with weakened immune systems. C. auris can cause invasive candidiasis (fungemia) in which the bloodstream, the central nervous system, and internal organs are infected. It has attracted widespread attention because of its multiple drug resistance. Treatment is also complicated because it is easily misidentified as other Candida species.

<span class="mw-page-title-main">2018 American salmonella outbreak</span>

The 2018 American salmonella outbreak was an American foodborne disaster that started in Iowa, spreading to 7 other states, sickening as many as 265 people, killing one, with 94 hospitalized. Ready-to-eat chicken salad was produced by Iowa-based Triple T Specialty Meats Inc. between January 2 and February 7 for distribution in Fareway grocery stores. Salad was sold in containers of various weights at Fareway stores deli from January 4 to February 9. Total of approximately 20 630 pounds of chicken were deemed contaminated with Salmonella Typhimurium at the time of recall on February 21.

<span class="mw-page-title-main">Measles resurgence in the United States</span> Sharp increase in measles cases between 2010 and 2019

Measles was declared eliminated from the United States in 2000 by the World Health Organization due to the success of vaccination efforts. However, it continues to be reintroduced by international travelers, and in recent years, anti-vaccination sentiment has allowed for the reemergence of measles outbreaks.

References

  1. 1 2 3 Sarah Kaplan (18 March 2016). "The mysterious infection that might be behind 17 deaths in Wisconsin has spread to a second state". Washington Post.
  2. 1 2 3 Gallardo, Michelle. "Illinois Death Linked to Elizabethkingia Outbreak That Killed 18". ABC 7 Eyewitness News. WLS-TV. Retrieved April 14, 2016.
  3. 1 2 "Multistate Outbreak of Infections Caused by Elizabethkingia anophelis". Centers for Disease Control and Prevention (CDC). June 16, 2016. Retrieved June 19, 2016.
  4. 1 2 3 4 5 Wisconsin Department of Health Services: "Wisconsin 2016 Elizabethkingia anophelis outbreak", last revised: March 30, 2016.
  5. Perrin A, Larsonneur E, Nicholson AC, Edwards DJ, Gundlach KM, Whitney AM, Gulvik CA, Bell ME, Rendueles O, Cury J, Hugon P, Clermont D, Enouf V, Loparev V, Juieng P, Monson T, Warshauer D, Elbadawi LI, Walters MS, Crist MB, Noble-Wang J, Borlaug G, Rocha EP, Criscuolo A, Touchon M, Davis JP, Holt KE, McQuiston JR, Brisse S (2017). "Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain". Nat Commun. 8: 15483. Bibcode:2017NatCo...815483P. doi:10.1038/ncomms15483. PMC   5458099 . PMID   28537263.
  6. "A mysterious infection may have killed 18 people in Wisconsin, and health officials aren't sure why". Msn.com. Archived from the original on March 13, 2016. Retrieved March 11, 2016.
  7. "Rare Elizabethkingia Bacteria Outbreak Infects 44 in Wisconsin, Killing 18 – ABC News". Abcnews.go.com. March 4, 2016. Retrieved March 11, 2016.
  8. Ehlke, Gretchen. "Source of bloodstream infection in Wisconsin unknown". The Washington Post . Archived from the original on March 10, 2016. Retrieved March 11, 2016.
  9. 1 2 WISN 12 News: "Cases of blood infection reported in Southeast Wisconsin | 44 cases of Elizabethkingia anophelis reported since Nov. 1", March 3, 2016.
  10. "CDC offers new call to arms on nightmare bacteria". PBS NewsHour. 4 August 2015. Retrieved March 11, 2016.