Nicole Pratt was the defending champion, but decided not to participate that year.
Bethanie Mattek-Sands and Horia Tecău were the defending champions, but lost in the first round to Lucie Hradecká and František Čermák.
Heather Watson was the defending champion, but she lost in the first round to Monica Puig.
Samantha Stosur won the title for the second time, defeating Eugenie Bouchard in the final, 3–6, 7–5, 6–2.
Sara Errani and Roberta Vinci were the defending champions, but withdrew from the semifinals against Tímea Babos and Kristina Mladenovic.
Anna-Lena Grönefeld and Květa Peschke won the title, defeating Babos and Mladenovic in the final, 6–7(7–9), 6–4, [10–5].
Serena Williams was the defending champion, but withdrew before the tournament began.
Mona Barthel won the title, defeating Chanelle Scheepers in the final, 6–3, 7–6(7–3).
Angelique Kerber was the defending champion, but she chose not to participate this year.
Tsvetana Pironkova was the defending champion, but lost in the semifinals to Petra Kvitová.
Anna Smashnova-Pistolesi was the defending champion, but lost in second round to Marta Domachowska.
Liang En-shuo won the girls' singles title at the 2018 Australian Open, defeating Clara Burel in the final, 6–3, 6–4.
Liang En-shuo and Wang Xinyu won the Girls' Doubles tennis title at the 2018 Australian Open, defeating Violet Apisah and Lulu Sun in the final, 7–6(7–4), 4–6, [10–5].
Venus Williams was the defending champion, but did not compete this year.
Virginia Ruano Pascual was the defending champion, but decided to compete in Moscow at the same week.
Karolína Plíšková was the defending champion, but lost in the second round to Victoria Azarenka.
Aleksandra Krunić was the defending champion, but lost to Kirsten Flipkens in the first round, in a rematch of the previous year's final.
This was the first edition of the tournament.
Martina Hingis and Anna Kournikova were the defending champions, but withdrew before their semifinal match against Justine Henin and Meghann Shaughnessy.
Elina Svitolina was the defending champion, but decided not to participate.
Elina Svitolina was the defending champion but chose not to participate.
The 2021 Ladies Open Lausanne was a women's tennis tournament played on outdoor clay courts. It was the 28th edition of the Ladies Open Lausanne, and part of the 250 category of the 2021 WTA Tour. It took place at Tennis Club Stade-Lausanne in Lausanne, Switzerland, from 12 through 18 July 2021.
This was the first edition of the tournament.
Susan Bandecchi 
Ulrikke Eikeri 
Valentini Grammatikopoulou 
