APOL3

APOL3
Identifiers
Aliases	APOL3 , APOLIII, CG121, CG12_1, apoL-III, apolipoprotein L3
External IDs	OMIM: 607253 HomoloGene: 129701 GeneCards: APOL3
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,166,177 bp
RNA expression pattern
	Top expressed in
	monocyte; ; gastric mucosa; ; pericardium; ; lymph node; ; spleen; ; subcutaneous adipose tissue; ; right lung; ; upper lobe of left lung; ; left uterine tube; ; Achilles tendon;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity ; lipid binding ; lipid transporter activity ;
Cellular component	cytoplasm ; extracellular region ; membrane ;
Biological process	lipoprotein metabolic process ; positive regulation of I-kappaB kinase/NF-kappaB signaling ; lipid transport ; inflammatory response ; signal transduction ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	80833
	n/a
	ENSG00000128284
	n/a
	O95236
	n/a
NM_014349 ; NM_030644 ; NM_145639 ; NM_145640 ; NM_145641 ;
	NM_145642
	n/a
NP_055164 ; NP_085147 ; NP_663614 ; NP_663615 ; NP_663616 ;
	NP_663617
	n/a
	Wikidata
View/Edit Human

Last updated March 05, 2023

Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene.^[3]^[4] Expressed in the gut, it has antibiotic properties.^[5]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.^[4]

Related Research Articles

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Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene.

Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.

The nuclear receptor 4A3 (NR4A3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene. NR4A3 is a member of the nuclear receptor family of intracellular transcription factors.

ATP-binding cassette transporter ABCA1, also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene. This transporter is a major regulator of cellular cholesterol and phospholipid homeostasis.

Oxidized low-density lipoprotein receptor 1 also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.

Baculoviral IAP repeat-containing protein3 is a protein that in humans is encoded by the BIRC3 gene.

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.

Apolipoprotein M is a protein that in humans is encoded by the APOM gene.

Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.

Apolipoprotein L1 is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different isoforms have been found for this gene.

Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene.

Stannin is a protein that in humans is encoded by the SNN gene.

Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene.

Copine-1 is a protein that in humans is encoded by the CPNE1 gene.

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene.

Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene. It is preferentially expressed in human immune cell types.

Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128284 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
1 2 "Entrez Gene: APOL3 apolipoprotein L, 3".
↑ Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, et al. (2021). "A human apolipoprotein L with detergent-like activity kills intracellular pathogens". Science. 373 (6552): eabf8113. doi:10.1126/science.abf8113. PMC 8422858 . PMID 34437126. S2CID 235915023.

External links

Human APOL3 genome location and APOL3 gene details page in the UCSC Genome Browser .

Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (May 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Duchateau PN, Pullinger CR, Cho MH, Eng C, Kane JP (April 2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". Journal of Lipid Research. 42 (4): 620–30. doi: 10.1016/S0022-2275(20)31171-8 . PMID 11290834.
Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (April 2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue". Genomics. 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, et al. (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi: 10.1038/sj.onc.1206406 . PMID 12761501.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604 . PMID 15461802.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (March 2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128284 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11374903-3] Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.

[entrez-4] 1 2 "Entrez Gene: APOL3 apolipoprotein L, 3".

[5] Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, et al. (2021). "A human apolipoprotein L with detergent-like activity kills intracellular pathogens". Science. 373 (6552): eabf8113. doi:10.1126/science.abf8113. PMC 8422858 . PMID 34437126. S2CID 235915023.

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APOL3

Contents

Related Research Articles

References

External links

Further reading