ARFGAP3

ARFGAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRW
Identifiers
Aliases	ARFGAP3 , ARFGAP1, ADP ribosylation factor GTPase activating protein 3
External IDs	OMIM: 612439 MGI: 1913501 HomoloGene: 134103 GeneCards: ARFGAP3
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.2 Start 42,796,502 bp [1] End 42,858,106 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 83,183,940 bp [2] End 83,234,448 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa parotid gland body of pancreas Achilles tendon tibia Left adrenal gland corpus epididymis islet of Langerhans palpebral conjunctiva seminal vesicula Top expressed in lacrimal gland seminal vesicula salivary gland parotid gland islet of Langerhans submandibular gland spermatocyte duodenum spermatid large intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity Cellular component cytosol Golgi membrane Golgi apparatus membrane cytoplasm endoplasmic reticulum-Golgi intermediate compartment trans-Golgi network COPI vesicle coat Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intracellular protein transport vesicle-mediated transport protein secretion retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum positive regulation of GTPase activity transport COPI coating of Golgi vesicle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26286 66251 Ensembl ENSG00000242247 ENSMUSG00000054277 UniProt Q9NP61 Q9D8S3 RefSeq (mRNA) NM_001142293 NM_014570 NM_025445 NM_001357756 NM_001357757 RefSeq (protein) NP_001135765 NP_055385 NP_079721 NP_001344685 NP_001344686 Location (UCSC) Chr 22: 42.8 – 42.86 Mb Chr 15: 83.18 – 83.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene. ^{[5] [6] [7]}

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000242247 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054277 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang C, Yu Y, Zhang S, Liu M, Xing G, Wei H, Bi J, Liu X, Zhou G, Dong C, Hu Z, Zhang Y, Luo L, Wu C, Zhao S, He F (Jul 2000). "Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family". Genomics. 63 (3): 400–8. doi:10.1006/geno.1999.6095. PMID   10704287.
6. Liu X, Zhang C, Xing G, Chen Q, He F (Feb 2001). "Functional characterization of novel human ARFGAP3". FEBS Lett. 490 (1–2): 79–83. doi:10.1016/S0014-5793(01)02134-2. PMID   11172815. S2CID   34808599.
7. "Entrez Gene: ARFGAP3 ADP-ribosylation factor GTPase activating protein 3".

External links

• Human ARFGAP1 genome location and ARFGAP1 gene details page in the UCSC Genome Browser .
• Human ARFGAP3 genome location and ARFGAP3 gene details page in the UCSC Genome Browser .

Further reading

• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID   8076819.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC   430954 . PMID   12529303.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.