Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheromatous plaque. At onset there are usually no symptoms, but if they develop, symptoms generally begin around middle age. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which arteries are affected.
A citation is a reference to a source. More precisely, a citation is an abbreviated alphanumeric expression embedded in the body of an intellectual work that denotes an entry in the bibliographic references section of the work for the purpose of acknowledging the relevance of the works of others to the topic of discussion at the spot where the citation appears.
Pulmonary embolism (PE) is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream (embolism). Symptoms of a PE may include shortness of breath, chest pain particularly upon breathing in, and coughing up blood. Symptoms of a blood clot in the leg may also be present, such as a red, warm, swollen, and painful leg. Signs of a PE include low blood oxygen levels, rapid breathing, rapid heart rate, and sometimes a mild fever. Severe cases can lead to passing out, abnormally low blood pressure, obstructive shock, and sudden death.
Open access (OA) is a set of principles and a range of practices through which research outputs are distributed online, free of access charges or other barriers. Under some models of open access publishing, barriers to copying or reuse are also reduced or removed by applying an open license for copyright.
Deep vein thrombosis (DVT) is a type of venous thrombosis involving the formation of a blood clot in a deep vein, most commonly in the legs or pelvis. A minority of DVTs occur in the arms. Symptoms can include pain, swelling, redness, and enlarged veins in the affected area, but some DVTs have no symptoms. The most common life-threatening concern with DVT is the potential for a clot to embolize, travel as an embolus through the right side of the heart, and become lodged in a pulmonary artery that supplies blood to the lungs. This is called a pulmonary embolism (PE). DVT and PE comprise the cardiovascular disease of venous thromboembolism (VTE). About two-thirds of VTE manifests as DVT only, with one-third manifesting as PE with or without DVT. The most frequent long-term DVT complication is post-thrombotic syndrome, which can cause pain, swelling, a sensation of heaviness, itching, and in severe cases, ulcers. Recurrent VTE occurs in about 30% of those in the ten years following an initial VTE.
The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke. Originally formed in New York City in 1915, it is currently headquartered in Dallas, Texas. The American Heart Association is a national voluntary health agency.
A thoracic aortic aneurysm is an aortic aneurysm that presents primarily in the thorax.
The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as indexed by Clarivate's Web of Science.
Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines. Released in beta in November 2004, the Google Scholar index includes peer-reviewed online academic journals and books, conference papers, theses and dissertations, preprints, abstracts, technical reports, and other scholarly literature, including court opinions and patents.
Calcification is the accumulation of calcium salts in a body tissue. It normally occurs in the formation of bone, but calcium can be deposited abnormally in soft tissue, causing it to harden. Calcifications may be classified on whether there is mineral balance or not, and the location of the calcification. Calcification may also refer to the processes of normal mineral deposition in biological systems, such as the formation of stromatolites or mollusc shells.
Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. Topics covered include immunology, inflammation, infectious disease, hematopoiesis, cancer, stem cells and vascular biology. The journal has no single editor-in-chief, but thirteen academic editors.
Lines of Zahn are a characteristic of thrombi. They have layers, with lighter layers of platelets and fibrin, and darker layers of red blood cells. They are more present on thrombi formed with faster blood flow, more so on thrombi from the heart and aorta. They are only seen on thrombi formed before death. They are named after German–Swiss pathologist Friedrich Wilhelm Zahn.
Clinical Science is a peer-reviewed medical journal that covers all areas of clinical investigation, with a focus on translational science and medicine. The journal is currently published biweekly by Portland Press on behalf of the Biochemical Society.
Esterified estrogens (EEs), sold under the brand names Estratab and Menest among others, is an estrogen medication which is used hormone therapy for menopausal symptoms and low sex hormone levels in women, to treat breast cancer in both women and men, and to treat prostate cancer in men. It is formulated alone or in combination with methyltestosterone. It is taken by mouth.
Denisa D. Wagner is an American scientist currently the Edwin Cohn Professor of Pediatrics at Boston Children's Hospital (BCH), Harvard Medical School. Wagner first arrived in the United States in 1975 as a refugee from Czechoslovakia. She received her PhD in Biology from the Massachusetts Institute of Technology and taught at the University of Rochester and Tufts University before joining the Harvard faculty in 1994.The Wagner Lab contributes in the fields of vascular biology, inflammation, and thrombosis. Her Lab focuses on how blood cells and endothelial cells respond to vascular injury. Also her lab has been studying NETs for more than a decade. In 2015, research from the lab shed light on healing wounds in patients with diabetes. In the same year she received the Robert P. Grant Medal, which is the highest award of the International Society on Thrombosis and Hemostasis (ISTH).
Robert Wayne Alexander was an American biologist and cardiologist known for research in the fields of atherosclerosis, hypertension, and vascular biology.
George (Rick) Stouffer M.D. is Chief of the Division of Cardiology at the University of North Carolina Medical Center, where he is a practicing interventional cardiologist. Stouffer was awarded the Ernest and Hazel Craige Distinguished Professorship of Medicine in 2018; prior to that he was the Henry A. Foscue Distinguished Professor of Medicine. Stouffer is also co-director of the McAllister Heart Institute. He is known for his research regarding inpatient ST elevation myocardial infarctions.
Elisabetta Dejana is an Italian cell biologist and an expert on regulation of vascular system development. She has published widely and is frequently cited for her work. She has received several important awards. Dejana is a full professor at the University of Milan and has also been appointed full professor at the Department of Immunology, Genetics and Pathology at Uppsala University in Sweden.
Owen McCarty, Ph.D. is an American biomedical engineer who studies the dynamics of the vascular system in the context of cancer
Esther Lutgens is a Dutch physician and molecular biologist who is Professor of Vascular Immunopathology at Amsterdam University Medical Centre. She studies the modulation of co-stimulatory pathways and the immune system.
