See also artificial metalloenzyme.
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An artificial enzyme is a synthetic organic molecule or ion that recreates one or more functions of an enzyme. It seeks to deliver catalysis at rates and selectivity observed in naturally occurring enzymes.
Enzyme catalysis of chemical reactions occur with high selectivity and rate. The substrate is activated in a small part of the enzyme's macromolecule called the active site. There, the binding of a substrate close to functional groups in the enzyme causes catalysis by so-called proximity effects. It is possible to create similar catalysts from small molecules by combining substrate-binding with catalytic functional groups. Classically, artificial enzymes bind substrates using receptors such as cyclodextrin, crown ethers, and calixarene. [1] [2]
Artificial enzymes based on amino acids or peptides have expanded the field of artificial enzymes or enzyme mimics. For instance, scaffolded histidine residues mimic certain metalloproteins and enzymes such as hemocyanin, tyrosinase, and catechol oxidase. [3]
Artificial enzymes have been designed from scratch via a computational strategy using Rosetta. [4] A December 2014 publication reported active enzymes made from molecules that do not occur in nature. [5] In 2016, a book chapter entitled "Artificial Enzymes: The Next Wave" was published. [6]
Nanozymes are nanomaterials with enzyme-like characteristics. [7] [8] They have been explored for applications such as biosensing, bioimaging, tumor diagnosis and therapy, and anti-biofouling. [9] [6] [10] [11] [12]
In 1996 and 1997, Dugan et al. discovered superoxide dismutase (SOD)-mimicking activities of fullerene derivatives. [13] [14]
The term "nanozyme" was coined in 2004 by Flavio Manea, Florence Bodar Houillon, Lucia Pasquato, and Paolo Scrimin. [15] A 2005 review article [16] attributed this term to "analogy with the activity of catalytic polymers (synzymes)", based on the "outstanding catalytic efficiency of some of the functional nanoparticles synthesized". In 2006, nanoceria (CeO2 nanoparticles) was reported to prevent retinal degeneration induced by intracellular peroxides (toxic reactive oxygen intermediates) in rat. [17] This was seen as indicating a possible route to a treatment for certain causes of blindness. [18] In 2007 intrinsic peroxidase-like activity of ferromagnetic nanoparticles was reported by Yan Xiyun and coworkers as suggesting a wide range of applications in, for example, medicine and environmental chemistry, and the authors designed an immunoassay based on this property. [19] [20] Hui Wei and Erkang Wang then (2008) used this property of easily prepared magnetic nanoparticles to demonstrate analytical applications to bioactive molecules, describing a colorimetric assay for hydrogen peroxide (H
2O
2) and a sensitive and selective platform for glucose detection. [21]
As of 2016 [update] , many review articles have appeared. [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] A book-length treatment appeared in 2015, described as providing "a broad portrait of nanozymes in the context of artificial enzyme research", [35] and a 2016 Chinese book on enzyme engineering included a chapter on nanozymes. [36]
Colorimetric applications of peroxidase mimesis in different preparations were reported in 2010 and 2011, detecting, respectively, glucose (via carboxyl-modified graphene oxide) [37] and single-nucleotide polymorphisms (in a label-free method relying on hemin−graphene hybrid nanosheets), [38] with advantages in both cost and convenience. A use of colour to visualise tumour tissues was reported in 2012, using the peroxidase mimesis of magnetic nanoparticles coated with a protein that recognises cancer cells and binds to them. [39]
Also in 2012, nanowires of vanadium pentoxide (vanadia, V2O5) were shown to suppress marine biofouling by mimicry of vanadium haloperoxidase, with anticipated ecological benefits. [40] A study at a different centre two years later reported V2O5 showing mimicry of glutathione peroxidase in vitro in mammalian cells, suggesting future therapeutic application. [41] The same year, a carboxylated fullerene dubbed C3 was reported to be neuroprotective in a primate model of Parkinson's disease. [42]
In 2015, a supramolecular nanodevice was proposed for bioorthogonal regulation of a transitional metal nanozyme, based on encapsulating the nanozyme in a monolayer of hydrophilic gold nanoparticles, alternately isolating it from the cytoplasm or allowing access according to a gatekeeping receptor molecule controlled by competing guest species; the device, aimed at imaging and therapeutic applications, is of biomimetic size and was successful within the living cell, controlling pro-fluorophore and prodrug activation. [43] [44] An easy means of producing Cu(OH)
2 supercages was reported, along with a demonstration of their intrinsic peroxidase mimicry. [45] A scaffolded "INAzyme" ("integrated nanozyme") arrangement was described, locating hemin (a peroxidase mimic) with glucose oxidase (GOx) in sub-micron proximity, providing a fast and efficient enzyme cascade reported as monitoring cerebral brain-cell glucose dynamically in vivo. [46] A method of ionising hydrophobe-stabilised colloid nanoparticles was described, with confirmation of their enzyme mimicry in aqueous dispersion. [47] De novo designed metallopeptides with self-assembling properties carry out the oxidation reaction of dimethoxyphenol. [48]
Field trials in West Africa were announced of a magnetic nanoparticle–amplified rapid low-cost strip test for Ebola virus. [49] [50] H
2O
2 was reported as displacing label DNA, adsorbed to nanoceria, into solution, where it fluoresces, providing a highly sensitive glucose test. [51] Oxidase-like nanoceria was used for developing self-regulated bioassays. [52] Multi-enzyme mimicking Prussian blue was developed for therapeutics. [53] A review on metal organic framework (MOF)-based enzyme mimics was published. [54] Histidine was used to modulate iron oxide nanoparticles' peroxidase-mimicking activities. [55] Gold nanoparticles' peroxidase-mimicking activities were modulated via a supramolecular strategy for cascade reactions. [56] A molecular imprinting strategy was developed to improve the selectivity of Fe3O4 nanozymes with peroxidase-like activity. [57] A new strategy was developed to enhance the peroxidase-mimicking activity of gold nanoparticles by using hot electrons. [58] Researchers designed gold nanoparticle–based integrative nanozymes with both surface-enhanced Raman scattering and peroxidase-mimicking activities for measuring glucose and lactate in living tissues. [59] Cytochrome c oxidase mimicking activity of Cu2O nanoparticles was modulated by receiving electrons from cytochrome c. [60] Fe3O4 nanoparticles were combined with glucose oxidase for tumor therapeutics. [61] Manganese dioxide nanozymes were used as cytoprotective shells. [62] An Mn3O4 nanozyme for Parkinson's disease (cellular model) was reported. [63] Heparin elimination in live rats was monitored with two-dimensional MOF-based peroxidase mimics and AG73 peptide. [64] Glucose oxidase and iron oxide nanozymes were encapsulated within multi-compartmental hydrogels for incompatible tandem reactions. [65] A cascade nanozyme biosensor was developed for detection of viable Enterobacter sakazakii. [66] An integrated nanozyme of GOx@ZIF-8(NiPd) was developed for tandem catalysis. [67] Charge-switchable nanozymes were developed. [68] Site-selective RNA splicing nanozyme was developed. [69] A nanozymes special issue in Progress in Biochemistry and Biophysics was published. [70] Mn3O4 nanozymes with the ability to scavenge reactive oxygen species were developed and showed in vivo anti-inflammatory activity. [71] A proposal entitled "A Step into the Future – Applications of Nanoparticle Enzyme Mimics" was presented. [72] Facet-dependent oxidase and peroxidase-like activities of palladium nanoparticles were reported. [73] Au@Pt multibranched nanostructures as bifunctional nanozymes were developed. [74] Ferritin-coated carbon nanozymes were developed for tumor catalytic therapy. [75] CuO nanozymes were developed to kill bacteria in a light-controlled manner. [76] Enzymatic activity of oxygenated CNT was studied. [77] Nanozymes were used to catalyze the oxidation of L-tyrosine and L-phenylalanine to dopachrome. [78] Nanozymes were presented as an emerging alternative to natural enzyme for biosensing and immunoassays. [79] A standardized assay was proposed for peroxidase-like nanozymes. [80] Semiconductor quantum dots were utilized as nucleases for site-selective photoinduced cleavage of DNA. [81] Two-dimensional MOF nanozyme-based sensor arrays were constructed for detecting phosphates and probing their enzymatic hydrolysis. [82] Nitrogen-doped carbon nanomaterials as specific peroxidase mimics were reported. [83] Nanozyme sensor arrays were developed to detect analytes from small molecules to proteins and cells. [84] A copper oxide nanozyme for Parkinson's disease was reported. [85] Exosome-like nanozyme vesicles for tumor imaging were developed. [86] A comprehensive review on nanozymes was published by Chemical Society Reviews. [8] A progress report on nanozymes was published. [87] eg occupancy as an effective descriptor was developed for the catalytic activity of perovskite oxide–based peroxidase mimics. [88] A Chemical Reviews paper on nanozymes was published. [89] A single-atom strategy was used to develop nanozymes. [90] [91] [92] [93] A nanozyme for metal-free bioinspired cascade photocatalysis was reported. [94] Chemical Society Reviews published a tutorial review on nanozymes. [95] Cascade nanozyme reactions to fix CO2 were reported. [96] Peroxidase-like gold nanoclusters were used to monitor renal clearance. [97] A copper–carbon hybrid nanozyme was developed for antibacterial therapy. [98] A ferritin nanozyme was developed to treat cerebral malaria. [99] Accounts of Chemical Research reviewed nanozymes. [100] A new strategy called strain effect was developed to modulate metal nanozyme activity. [101] Prussian blue nanozymes were used to detect hydrogen sulfide in the brains of living rats. [102] Photolyase-like CeO2 was reported. [103] An editorial on nanozymes titled "Can Nanozymes Have an Impact on Sensing?" was published. [104]
A single-atom nanozyme was developed for sepsis management. [105] Self-assembled single-atom nanozyme was developed for photodynamic therapy of tumors. [106] An ultrasound-switchable nanozyme against multidrug-resistant bacterial infection was reported. [107] A nanozyme-based H2O2 homeostasis disruptor for chemodynamic tumor therapy was reported. [108] An iridium oxide nanozyme for cascade reaction was developed for tumor therapy. [109] A book entitled Nanozymology was published. [110] A free radical–scavenging nanosponge was engineered for ischemic stroke. [111] A minireview was published on gold-conjugate-based nanozymes. [112] SnSe nanosheets as dehydrogenase mimics were developed. [113] A carbon dot–based topoisomerase I mimic was reported to cleave DNA. [114] Nanozyme sensor arrays were developed to detect pesticides. [115] Bioorthogonal nanozymes were used to treat bacterial biofilms. [116] A rhodium nanozyme was developed for treat colon disease. [117] A Fe-N-C nanozyme was developed to study drug–drug interactions. [118] A polymeric nanozyme was developed for second near-infrared photothermal cancer ferrotherapy. [119] A Cu5.4O nanozyme was reported for anti-inflammation therapy. [120] A CeO2@ZIF-8 nanozyme was developed to treat reperfusion-induced injury in ischemic stroke. [121] Peroxidase-like activity of Fe3O4 was explored to study the electrocatalytic kinetics at the single-molecule/single-particle level. [122] A Cu-TA nanozyme was fabricated to scavenge reactive oxygen species from cigarette smoke. [123] A metalloenzyme-like copper nanocluster was reported to have anticancer and imaging activities simultaneously. [124] An integrated nanozyme was developed for anti-inflammation therapy. [125] Enhanced enzyme-like catalytic activity was reported under non-equilibrium conditions for gold nanozymes. [126] A density functional theory method was proposed to predict the activities of peroxidase-like nanozymes. [127] A hydrolytic nanozyme was developed to construct an immunosensor. [128] An orally administered nanozyme was developed for inflammatory bowel disease therapy. [129] A ligand-dependent activity engineering strategy was reported to develop a glutathione peroxidase–mimicking MIL-47(V) metal–organic framework nanozyme for therapy. [130] A single-site nanozyme was developed for tumor therapy. [131] A SOD-like nanozyme was developed to regulate the mitochondria and neural cell function. [132] A Pd12 coordination cage as a photoregulated oxidase-like nanozyme was developed. [133] An NADPH oxidase-like nanozyme was developed. [134] A catalase-like nanozyme was developed for tumor therapy. [135] A defect-rich adhesive molybdenum disulfide/reduced graphene oxide nanozyme was developed for anti-bacterial activity. [136] A MOF@COF nanozyme was developed for anti-bacterial activity. [137] Plasmonic nanozymes were reported. [138] Tumor microenvironment–responsive nanozyme was developed for tumor therapy. [139] A protein-engineering-inspired method was developed to design highly active nanozymes. [140] An editorial on nanozymes definition was published. [141] A nanozyme therapy for hyperuricemia and ischemic stroke was developed. [142] Chemistry World published a perspective on artificial enzymes and nanozymes. [143] A review on single-atom catalysts, including single-atom nanozymes, was published. [144] Peroxidase-like mixed-FeCo-oxide-based surface-textured nanostructures (MTex) were used for biofilm eradication. [145] A nanozyme with better kinetics than natural peroxidase was developed. [146] A self-protecting nanozyme was developed for Alzheimer's disease. [147] CuSe nanozymes was developed to treat Parkinson's disease. [148] A nanocluster-based nanozyme was developed. [149] Glucose oxidase–like gold nanoparticles combined with cyclodextran were used for chiral catalysis. [150] An artificial binuclear copper monooxygenase in a MOF was developed. [151] A review on highly efficient design of nanozymes was published. [152] Ni–Pt peroxidase mimics were developed for bioanalysis. [153] A POM-based nanozyme was reported to protect cells from reactive oxygen species. [154] A gating strategy was used to prepare selective nanozymes. [155] A manganese single-atom nanozyme was developed for tumor therapy. [156] A pH-responsive oxidase-like graphitic nanozyme was developed for selective killing of Helicobacter pylori . [157] An engineered FeN3P-centred single-atom nanozyme was developed. [158] Peroxidase- and catalase-like activities of gold nanozymes were modulated. [159] Graphdiyne–cerium oxide nanozymes were developed for radiotherapy of esophageal cancer. [160] Defect engineering was used to develop nanozyme for tumor therapy. [161] A book entitled Nanozymes for Environmental Engineering was published. [162] A palladium single-atom nanozyme was developed for tumor therapy. [163] A horseradish peroxidase–like nanozyme was developed for tumor therapy. [164] The mechanism of a GOx-like nanozyme was reported. [165] A review on nanozymes was published. [166] A mechanism study on nanonuclease-like nanozyme was reported. [167] A perspective on nanozyme definition was published. [168] Aptananozymes were developed. [169] Ceria nanozyme loaded microneedles helped hair regrowth. [170] A catalase-like platinum nanozyme was used for small extracellular vesicles analysis. [171] A book on Nanozymes: Advances and Applications was published by CRC Press. [172] A review on nanozyme catalytic turnover was published. [173] A nanozyme was developed for ratiometric molecular imaging. [174] A Fe3O4/Ag/Bi2MoO6 photoactivatable nanozyme was developed for cancer therapy. [175] Co/C as an NADH oxidase mimic was reported. [176] An iron oxide nanozyme was used to target biofilms causing tooth decay. [177] A new strategy for high-performance nanozymes was developed. [178] A high-throughput computational screening strategy was developed to discover SOD-like nanozymes. [179] A review paper entitled "Nanozyme-Enabled Analytical Chemistry" was published in Analytical Chemistry. [180] A nanozyme-based therapy for gout was reported. [181] A data-informed strategy for discovery of nanozymes was reported. [182] [183] Prussian blue nanozyme was used to alleviates neurodegeneration. [184] A dual element single-atom nanozyme was developed. [185] A valence-engineered method was developed to design antioxidant banozyme for biomedical applications. [186] Combined with small interfering RNA, ceria nanozyme was used for synergistic treatment of neurodegenerative diseases. [187] A universal assay for catalase-like nanozymes was reported. [188] A nanozyme catalyzed CRISPR assay was developed. [189] A nanozyme-based tumor-specific photo-enhanced catalytic therapy was developed. [190] Single-atom nanozymes for brain trauma therapy were reported. [191] An edge engineering strategy was developed to fabriacte single atom nanozymes. [192] A single atom nanozyme was developed to modulate tumor microenvironment for therapy. [193] A new mechanism for peroxidase-like Fe3O4 was proposed. [194] A plant virus cleaving nanozyme was reported. [195] Nanozymes is selected as one of the IUPAC Top Ten Emerging Technologies in Chemistry 2022. [196] A book entitled "Nanozymes: Design, Synthesis, and Applications" was published by ACS. [197] Nanozymes were used to remove and degrade microplastics. [198] A cold-adapted nanozyme was reported. [199] A MOF-818 nanozyme with antioxidase-mimicking activities was used to treat diabetic chronic wounds. [200] Cu single-atom nanozymes were developed for catalytic tumor-specific therapy. [201] Machine learning was employed to search for nanozymes. [202] Enzyme-like meso-bacroporous carbon sphere was developed. [203] A combination of DNAzyme and nanozyme was reported. [204] A peroxidase-like photoexcited Ru single-atom nanozyme was reported. [205] A probiotic nanozyme hydrogel for Candida vaginitis therapy was developed. [206] A method to determine the maximum velocity of a peroxidase-like nanozyme was proposed. [207] Antisenescence nanozymes for atherosclerosis therapy were reported. [208] A book entitled 'Biomedical Nanozymes: From Diagnostics to Therapeutics' was published by Springer. [209] 2023 Dalton Division Horizon Prize was awarded to High-Performance Nanozyme Designer. [210] Nanozyme-cosmetic contact lenses were developed. [211] Biogenic ferritins act as natural nanozymes were reported. [212] An integrated computational and experimental framework for inverse screening of nanozymes was developed. [213] A diatomic iron nanozyme was reported. [214] Mechanism of carbon dot-based SOD-like nanozyme was studied. [215] A hybrid ceria nanozyme was developed for arthritis therapy. [216] A chiral nanozyme was reported for Parkinson's disease. [217] A dimensionality-engineered single-atom nanozyme was reported. [218] A liposome-base nanozyme was developed to treat infected diabetic wounds. [219] A single-site iron nanozyme was developed for alcohol detoxification. [220] A Pt nanozyme was developed to treat gouty arthritis. [221] Two nature reviews on nanozymes were published, focusing on nanohealthcare and in vivo applications. [222] [223] Combination of nanozyme and probiotics for IBD therapy. [224] An artificial metabzyme for tumour-cell-specific metabolic therapy was reported. [225]
A nanomotor is a molecular or nanoscale device capable of converting energy into movement. It can typically generate forces on the order of piconewtons.
Nanomaterial-based catalysts are usually heterogeneous catalysts broken up into metal nanoparticles in order to enhance the catalytic process. Metal nanoparticles have high surface area, which can increase catalytic activity. Nanoparticle catalysts can be easily separated and recycled. They are typically used under mild conditions to prevent decomposition of the nanoparticles.
As the world's energy demand continues to grow, the development of more efficient and sustainable technologies for generating and storing energy is becoming increasingly important. According to Dr. Wade Adams from Rice University, energy will be the most pressing problem facing humanity in the next 50 years and nanotechnology has potential to solve this issue. Nanotechnology, a relatively new field of science and engineering, has shown promise to have a significant impact on the energy industry. Nanotechnology is defined as any technology that contains particles with one dimension under 100 nanometers in length. For scale, a single virus particle is about 100 nanometers wide.
Photothermal therapy (PTT) refers to efforts to use electromagnetic radiation for the treatment of various medical conditions, including cancer. This approach is an extension of photodynamic therapy, in which a photosensitizer is excited with specific band light. This activation brings the sensitizer to an excited state where it then releases vibrational energy (heat), which is what kills the targeted cells.
An electrocatalyst is a catalyst that participates in electrochemical reactions. Electrocatalysts are a specific form of catalysts that function at electrode surfaces or, most commonly, may be the electrode surface itself. An electrocatalyst can be heterogeneous such as a platinized electrode. Homogeneous electrocatalysts, which are soluble, assist in transferring electrons between the electrode and reactants, and/or facilitate an intermediate chemical transformation described by an overall half reaction. Major challenges in electrocatalysts focus on fuel cells.
Sonodynamic therapy (SDT) is a noninvasive treatment, often used for tumor irradiation, that utilizes a sonosensitizer and the deep penetration of ultrasound to treat lesions of varying depths by reducing target cell number and preventing future tumor growth. Many existing cancer treatment strategies cause systemic toxicity or cannot penetrate tissue deep enough to reach the entire tumor; however, emerging ultrasound stimulated therapies could offer an alternative to these treatments with their increased efficiency, greater penetration depth, and reduced side effects. Sonodynamic therapy could be used to treat cancers and other diseases, such as atherosclerosis, and diminish the risk associated with other treatment strategies since it induces cytotoxic effects only when externally stimulated by ultrasound and only at the cancerous region, as opposed to the systemic administration of chemotherapy drugs.
Graphene quantum dots (GQDs) are graphene nanoparticles with a size less than 100 nm. Due to their exceptional properties such as low toxicity, stable photoluminescence, chemical stability and pronounced quantum confinement effect, GQDs are considered as a novel material for biological, opto-electronics, energy and environmental applications.
Micromotors are very small particles that can move themselves. The term is often used interchangeably with "nanomotor," despite the implicit size difference. These micromotors actually propel themselves in a specific direction autonomously when placed in a chemical solution. There are many different micromotor types operating under a host of mechanisms. Easily the most important examples are biological motors such as bacteria and any other self-propelled cells. Synthetically, researchers have exploited oxidation-reduction reactions to produce chemical gradients, local fluid flows, or streams of bubbles that then propel these micromotors through chemical media. Different stimuli, both external and internal can be used to control the behavior of these micromotors.
Carbon quantum dots also commonly called carbon nano dots or simply carbon dots are carbon nanoparticles which are less than 10 nm in size and have some form of surface passivation.
A polyhydride or superhydride is a compound that contains an abnormally large amount of hydrogen. This can be described as high hydrogen stoichiometry. Examples include iron pentahydride FeH5, LiH6, and LiH7. By contrast, the more well known lithium hydride only has one hydrogen atom.
Tribotronics is about the research on interaction between triboelectricity and semiconductor, which is using triboelectric potential controlling electrical transport and transformation in semiconductors for information sensing and active control (info-tribotronics), and using semiconductors managing triboelectric power transfer and conversion in circuits for power management and efficient utilization (power-tribotronics).
The borate fluorides or fluoroborates are compounds containing borate or complex borate ions along with fluoride ions that form salts with cations such as metals. They are in the broader category of mixed anion compounds. They are not to be confused with tetrafluoroborates (BF4) or the fluorooxoborates which have fluorine bonded to boron.
Single-Entity Electrochemistry (SEE) refers to the electroanalysis of an individual unit of interest. A unique feature of SEE is that it unifies multiple different branches of electrochemistry. Single-Entity Electrochemistry pushes the bounds of the field as it can measure entities on a scale of 100 microns to angstroms. Single-Entity Electrochemistry is important because it gives the ability to view how a single molecule, or cell, or "thing" affects the bulk response, and thus the chemistry that might have gone unknown otherwise. The ability to monitor the movement of one electron or ion from one unit to another is valuable, as many vital reactions and mechanisms undergo this process. Electrochemistry is well suited for this measurement due to its incredible sensitivity. Single-Entity Electrochemistry can be used to investigate nanoparticles, wires, vesicles, nanobubbles, nanotubes, cells, and viruses, and other small molecules and ions. Single-entity electrochemistry has been successfully used to determine the size distribution of particles as well as the number of particles present inside a vesicle or other similar structures
Polymer-protein hybrids are a class of nanostructure composed of protein-polymer conjugates. The protein component generally gives the advantages of biocompatibility and biodegradability, as many proteins are produced naturally by the body and are therefore well tolerated and metabolized. Although proteins are used as targeted therapy drugs, the main limitations—the lack of stability and insufficient circulation times still remain. Therefore, protein-polymer conjugates have been investigated to further enhance pharmacologic behavior and stability. By adjusting the chemical structure of the protein-polymer conjugates, polymer-protein particles with unique structures and functions, such as stimulus responsiveness, enrichment in specific tissue types, and enzyme activity, can be synthesized. Polymer-protein particles have been the focus of much research recently because they possess potential uses including bioseparations, imaging, biosensing, gene and drug delivery.
The iodate fluorides are chemical compounds which contain both iodate and fluoride anions (IO3− and F−). In these compounds fluorine is not bound to iodine as it is in fluoroiodates.
Yan Xiyun is a Chinese nanobiologist, academician of the Chinese Academy of Sciences, researcher and doctoral supervisor of the Institute of Biophysics, and professor of the University of the Chinese Academy of Sciences. Her main accomplishment was the discovery of nanozymes and its application in tumor diagnosis.
The borophosphates are mixed anion compounds containing borate and phosphate anions, which may be joined together by a common oxygen atom. Compounds that contain water or hydroxy groups can also be included in the class of compounds.
Sulfidogermanates or thiogermanates are chemical compounds containing anions with sulfur atoms bound to germanium. They are in the class of chalcogenidotetrelates. Related compounds include thiosilicates, thiostannates, selenidogermanates, telluridogermanates and selenidostannates.
Reduction-sensitive nanoparticles (RSNP) consist of nanocarriers that are chemically responsive to reduction. Drug delivery systems using RSNP can be loaded with different drugs that are designed to be released within a concentrated reducing environment, such as the tumor-targeted microenvironment. Reduction-Sensitive Nanoparticles provide an efficient method of targeted drug delivery for the improved controlled release of medication within localized areas of the body.
Selenidostannates are chemical compounds which contain anionic units of selenium connected to tin. They can be considered as stannates where selenium substitutes for oxygen. Similar compounds include the selenogermanates and thiostannates. They are in the category of chalcogenidotetrelates or more broadly chalcogenometallates.
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