Aspergillus alabamensis

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Aspergillus alabamensis [1]
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Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Fungi
Division: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Aspergillaceae
Genus: Aspergillus
Species:
A. alabamensis
Binomial name
Aspergillus alabamensis
Balajee (2009) [2]

Aspergillus alabamensis is a soil fungus in the division Ascomycota first described in 2009 as a segregated taxon of A. terreus. [3] [4] [5] Originally thought to be a variant of A. terreus, A. alabamensis is situated in a distinctive clade identified by genetic analysis. [2] While A. alabamensis has been found to be morphologically similar to Aspergillus terreus by morphological studies, the two differ significantly in active metabolic pathways, with A. alabamensis producing the mycotoxins citrinin and citreoviridin but lacking mevinolin. [2] [4]

Contents

History and etymology

Aspergillus alabamensis was discovered by Balajee and colleagues in 2009 while investigating the cryptic lineages in A. terreus in a multilocus sequence typing (MLST) study of three protein-encoding genes: enolase (enoA), β-tubulin (benA), and calmodulin (calM). [2] [6] They chose the species epithet "alabamensis" to reflect their geographic origin of strains comprising the new clade with 11 of the 14 isolates originating from clinical specimens obtained from the University of Alabama at Birmingham. [2] [7] The other three isolates were derived from soil samples collected in Argentina and Florida. [2]

Growth and morphology

Aspergillus alabamensis produces slow growing colonies that are wooly and white becoming yellow-brown to cinnamon-brown in colour with the onset of asexual sporulation. [2] Conidiophores are colourless and smooth with densely columnar conidial heads 30–50 μm in diameter and 150–500 μm in length. [2] The vesicles are subglobose with a diameter of 10–16 μm. [2] The metulae attached to the vesicles are closely packed, measuring 5.5–7.5 μm long by 1.5–2.0 μm wide. [2] Phialides attached to the apices of the metulae are 5.0–7.0 μm long by 2.0–2.5 μm wide. [2] The conidia arising from the tips of the phialides are slightly elliptical and smooth-walled reaching a diameter of 1.8–2.4 μm. [2] While Aspergillus alabamensis can grow between 25–50 °C, its optimal growth temperature is 37 °C. [2] [8] A. alabamensis can grow in vitro on a range of growth media including potato flake agar, [8] carnation leaf agar, [8] Czapek's yeast autolysate agar, [2] and malt extract agar. [2] This species is able to utilize glucose and sucrose as sources of carbon.

A. alabamensis has been cultivated on both Czapek yeast extract agar (CYA) plates and Malt Extract Agar Oxoid (MEAOX) plates. The growth morphology of the colonies can be seen in the pictures below.

Habitat and ecology

Similar to most species of Aspergillus , the spores of A. alabamensis are readily dispersed through the air and carried across long distances in the wind. A. alabamensis, is ubiquitous, having been found in South America, [2] North America [9] and Europe. [9] It shares similarities in both habitat and ecology with its sister species, A. terreus. Both are common found in soil, waste and compost. Aspergillus alabamensis is able to grow at water activities as low as those tolerated by A. terreus (e.g., aW = 0.78). [10] Unlike closely related Aspergilli, A. alabamensis is uncommon in soil, occurring mainly in plant debris where its presence has been suggested to be exclusive of Aspergillus niger (a common saprotroph), suggesting that A. alabamensis may be a natural antagonist of the latter. [11]

Disease

Aspergillus alabamensis is able to cause aspergillosis, although this species is rarely differentiated from the morphologically similar A. terreus because morphological studies are routinely used to identify and distinguish different clinical Aspergilli. [8] The adoption of DNA sequence-based analysis of critical genes such as β-tubulin and calmodulin is likely to expand the number of case reports of this and other cryptic agents of aspergillosis. [4] Notwithstanding, proper identification remains difficult due to the complexity involved in the sequencing process as well as the relatively high costs associated with these advanced techniques. [6] Recent studies have found that the crude extract of A. alabamensis cultures to exhibit antiisectan properties. [12] Samples derived from a dead hardwood branch near a river in northern Florida produced dioxomorpholines which showed insect repelling activity against Spodoptera frugiperda . [12] Similar to A. terreus, A. alabamensis exhibits a high minimum inhibitory concentration (MIC) to the antifungal drug amphotericin B [2] [3] [13] though it is generally thought susceptible to other antifungal drugs such as voriconazole, [2] [13] itraconazole, [2] and echinocandins. [13]

There have been no reported cases of invasive aspergillosis caused by A. alabamensis in humans. [14] However, given its similarity to A. terreus, it is likely that some case reports have been misattributed to the latter taxon. [5] It is recommended that patients suspected to have aspergillosis to be treated with first-line therapy drugs for the disease and have treatment modified base on in vitro susceptibility testing. [5] In cases of reported non-invasive aspergillosis caused by A. alabamensis, isolates are usually recovered from sputum, tracheal aspirates, ear canal, burn wounds [2] or the cystic fibrosis lung. [6] Immunocompromised individuals are more susceptible than immunocompetent people to aspergillosis.

In 2012, a case of disseminated aspergillosis in a 5-year-old female English springer spaniel was discovered suffering from vomiting (for seven days), loss of appetite and lethargy. [8] Dissemination of the disease is rare but localized infections are common. [8] In disseminated cases, organs which might become infected include the gallbladder, diaphragm, esophagus, and small intestine. [8]

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<i>Aspergillus clavatus</i> Species of fungus

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References

  1. ↑ "Catalogue of Life". Species 2000. Retrieved 16 October 2015.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Balajee, S. A.; Baddley, J. W.; Peterson, S. W.; Nickle, D.; Varga, J.; Boey, A.; Lass-Florl, C.; Frisvad, J. C.; Samson, R. A. (20 March 2009). "Aspergillus alabamensis, a New Clinically Relevant Species in the Section Terrei". Eukaryotic Cell. 8 (5): 713–722. doi:10.1128/EC.00272-08. PMC   2681604 . PMID   19304950.
  3. 1 2 Hadrich, Inès; Makni, Fattouma; Neji, Sourour; Abbes, Salma; Cheikhrouhou, Fatma; Trabelsi, Houaida; Sellami, Hayet; Ayadi, Ali (11 February 2012). "Invasive Aspergillosis: Resistance to Antifungal Drugs". Mycopathologia. 174 (2): 131–141. doi:10.1007/s11046-012-9526-y. PMID   22327841. S2CID   11172300.
  4. 1 2 3 Samson, R.A.; Peterson, S.W.; Frisvad, J.C.; Varga, J. (June 2011). "New species in Aspergillus section Terrei". Studies in Mycology. 69 (1): 39–55. doi:10.3114/sim.2011.69.04. PMC   3161753 . PMID   21892242.
  5. 1 2 3 Nedel, Wagner L.; Pasqualotto, Alessandro C. (13 September 2014). "Treatment of Infections by Cryptic Aspergillus Species". Mycopathologia. 178 (5–6): 441–5. doi:10.1007/s11046-014-9811-z. PMID   25216599. S2CID   13955268.
  6. 1 2 3 Rougeron, A.; Giraud, S.; Razafimandimby, B.; Meis, J.F.; Bouchara, J.-P.; Klaassen, C.H.W. (April 2014). "Different colonization patterns of Aspergillus terreus in patients with cystic fibrosis". Clinical Microbiology and Infection. 20 (4): 327–333. doi: 10.1111/1469-0691.12323 . PMID   23927682.
  7. ↑ "Aspergillus alabamensis". Index Fungorum. Retrieved 16 October 2015.
  8. 1 2 3 4 5 6 7 Burrough, Eric; Deitz, Krysta; Kinyon, Joann; Andreasen, Claire; Frana, Timothy; Sutton, Deanna; Thompson, Elizabeth; Fu, Jianmin; Wickes, Brian; Hostetter, Jesse (2012). "Disseminated aspergillosis in a dog due to Aspergillus alabamensis". Medical Mycology Case Reports. 1 (1): 1–4. doi:10.1016/j.mmcr.2012.02.002. PMC   3854705 . PMID   24371723.
  9. 1 2 Neal, Carolyn OS; Richardson, Aaron O; Hurst, Steven F; Tortorano, Anna; Viviani, Maria; Stevens, David A; Balajee, S Arunmozhi (2011). "Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering". BMC Microbiology. 11 (1): 203. doi: 10.1186/1471-2180-11-203 . PMC   3197500 . PMID   21923908.
  10. ↑ "Aspergillus terreus". University of Minnesota. Archived from the original on 23 September 2015. Retrieved 13 November 2015.
  11. ↑ Santos, Patrícia Oliveira dos; Silva, Augusto César Moura da; Corrêa, Élida Barbosa; Magalhães, Valter Cruz; Souza, Jorge Teodoro de (August 2014). "Additional species of Aspergillus causing bole rot disease in Agave sisalana". Tropical Plant Pathology. 39 (4): 331–4. doi: 10.1590/S1982-56762014000400008 .
  12. 1 2 Krausert, NM; Dowd, PF; Peterson, SW; Wicklow, DT; Gloer, JB (25 June 2015). "New antiinsectan dioxomorpholines from Aspergillus alabamensis NRRL 29810". Planta Medica. 81 (11). doi:10.1055/s-0035-1556409.
  13. 1 2 3 Arendrup, M.C. (June 2014). "Update on antifungal resistance in Aspergillus and Candida". Clinical Microbiology and Infection. 20: 42–48. doi: 10.1111/1469-0691.12513 . PMID   24372701.
  14. ↑ Van Der Linden, Jan W. M.; Warris, Adilia; Verweij, Paul E. (April 2011). "species intrinsically resistant to antifungal agents". Medical Mycology. 49 (S1): S82–9. doi: 10.3109/13693786.2010.499916 . PMID   20662634.
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