CA10

For the U.S. federal circuit court of appeals, see United States Court of Appeals for the Tenth Circuit. For the highway, see California State Route 10. For the congressional district, see California's 10th congressional district.

CA10
Identifiers
Aliases	CA10 , CA-RPX, CARPX, HUCEP-15, carbonic anhydrase 10
External IDs	OMIM: 604642; MGI: 1919855; HomoloGene: 23201; GeneCards: CA10; OMA:CA10 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.33-q22 Start 51,630,313 bp [1] End 52,160,017 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 D Start 92,988,854 bp [2] End 93,492,575 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis middle temporal gyrus prefrontal cortex dorsolateral prefrontal cortex pons right frontal lobe Brodmann area 23 Top expressed in lobe of cerebellum cerebellar vermis primary motor cortex habenula ventromedial nucleus anterior amygdaloid area Epithelium of choroid plexus cingulate gyrus prefrontal cortex piriform cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function carbonate dehydratase activity zinc ion binding carbonic anhydrase Cellular component cellular component Biological process brain development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56934 72605 Ensembl ENSG00000154975 ENSMUSG00000056158 UniProt Q9NS85 P61215 RefSeq (mRNA) NM_001082533 NM_001082534 NM_020178 NM_028296 NM_001361707 NM_001361708 RefSeq (protein) NP_001076002 NP_001076003 NP_064563 NP_082572 NP_001348636 NP_001348637 Location (UCSC) Chr 17: 51.63 – 52.16 Mb Chr 11: 92.99 – 93.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbonic anhydrase-related protein 10 is an enzyme that in humans is encoded by the CA10 gene. ^{[5] [6] [7]}

This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000154975 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056158 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hewett-Emmett D, Tashian RE (Aug 1996). "Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families". Mol Phylogenet Evol. 5 (1): 50–77. doi:10.1006/mpev.1996.0006. PMID   8673298.
6. Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL (Feb 1999). "CCG repeats in cDNAs from human brain". Hum Genet. 103 (6): 666–73. doi:10.1007/s004390050889. PMID   9921901. S2CID   23696667.
7. "Entrez Gene: CA10 carbonic anhydrase X".

External links

• Human CA10 genome location and CA10 gene details page in the UCSC Genome Browser .

Further reading

• Supuran CT, Scozzafava A, Casini A (2003). "Carbonic anhydrase inhibitors". Med Res Rev. 23 (2): 146–89. doi: 10.1002/med.10025 . PMID   12500287. S2CID   90349277.
• Supuran CT, Vullo D, Manole G, et al. (2005). "Designing of novel carbonic anhydrase inhibitors and activators". Curr Med Chem Cardiovasc Hematol Agents. 2 (1): 49–68. doi:10.2174/1568016043477305. PMID   15328829.
• Pastorekova S, Parkkila S, Pastorek J, Supuran CT (2004). "Carbonic anhydrases: current state of the art, therapeutic applications and future prospects". J Enzyme Inhib Med Chem. 19 (3): 199–229. doi:10.1080/14756360410001689540. PMID   15499993. S2CID   218868129.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Okamoto N, Fujikawa-Adachi K, Nishimori I, et al. (2001). "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain". Biochim. Biophys. Acta. 1518 (3): 311–6. doi:10.1016/s0167-4781(01)00193-2. PMID   11311946.
• Taniuchi K, Nishimori I, Takeuchi T, et al. (2002). "Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain". Neuroscience. 112 (1): 93–9. doi:10.1016/S0306-4522(02)00066-0. PMID   12044474. S2CID   31186391.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.