CA7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CA7 , CAVII, carbonic anhydrase 7, CA-VII | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 114770 MGI: 103100 HomoloGene: 55875 GeneCards: CA7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene. [5] [6]
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [6]
DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene.
Carbonic anhydrase II, is one of sixteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of bicarbonate ions in the proximal tubule. Loss of carbonic anhydrase activity in bones impairs the ability of osteoclasts to promote bone resorption, leading to osteopetrosis.
Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.
G-protein coupled receptor family C group 5 member B is a protein that in humans is encoded by the GPRC5B gene.
Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene.
Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene.
Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.
Carbonic anhydrase 12 is an enzyme that in humans is encoded by the CA12 gene.
Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene. It is also called 'gustin' because of its presence in saliva, and lower-than-normal levels of salivary zinc in individuals with hypogeusia.
Folylpolyglutamate synthase, mitochondrial is an enzyme that in humans is encoded by the FPGS gene.
Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl−/HCO3− exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have been linked to seizures.
Carbonic anhydrase-related protein is a protein that in humans is encoded by the CA8 gene. The CA8 protein lacks the catalytic activity of other carbonic anhydrase enzymes. A rare, autosomal recessive form of cerebellar ataxia known as "cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3" (CAMRQ3) is caused by mutations in the CA8 gene.
Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene.
Serine/threonine-protein kinase DCLK1 is an enzyme that in humans is encoded by the DCLK1 gene.
Carbonic anhydrase 5B, mitochondrial is an enzyme that in humans is encoded by the CA5B gene.
Carbonic anhydrase-related protein 11 is a protein that in humans is encoded by the CA11 gene.
Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.
Nucleotide-binding protein 2 also known as cytosolic Fe-S cluster assembly factor NUBP2 is a protein that in humans is encoded by the NUBP2 gene.
Carbonic anhydrase 13 is a protein that in humans is encoded by the CA13 gene.
Carbonic anhydrase 5A, mitochondrial is a protein that in humans is encoded by the CA5A gene.