COPS2

COPS2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4WSN
Identifiers
Aliases	COPS2 , ALIEN, CSN2, SGN2, TRIP15, COP9 signalosome subunit 2
External IDs	OMIM: 604508 HomoloGene: 134283 GeneCards: COPS2
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q21.1 Start 49,106,068 bp [1] End 49,155,661 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thoracic diaphragm Achilles tendon parietal pleura amniotic fluid corpus epididymis germinal epithelium caput epididymis deltoid muscle endometrium visceral pleura n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity transcription corepressor activity Cellular component nucleoplasm nucleus COP9 signalosome cytoplasm cytosol Biological process negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II nucleotide-excision repair, DNA damage recognition neuron differentiation cell population proliferation signal transduction negative regulation of nucleic acid-templated transcription skeletal muscle cell differentiation transcription-coupled nucleotide-excision repair neurogenesis negative regulation of transcription, DNA-templated protein deneddylation post-translational protein modification protein phosphorylation inner cell mass cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9318 n/a Ensembl ENSG00000166200 n/a UniProt P61201 n/a RefSeq (mRNA) NM_004236 NM_001143887 n/a RefSeq (protein) NP_001137359 NP_004227 n/a Location (UCSC) Chr 15: 49.11 – 49.16 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene. ^{[3] [4] [5]} It encodes a subunit of the COP9 signalosome.

Interactions

COPS2 has been shown to interact with:

• DAX1, ^[6]
• IRF8, ^[7]
• NIF3L1, ^[8] and
• THRA. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000166200 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi: 10.1210/mend.9.2.7776974 . PMID   7776974.
4. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (April 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi: 10.1096/fasebj.12.6.469 . PMID   9535219. S2CID   25424324.
5. "Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)".
6. Altincicek B, Tenbaum SP, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A (March 2000). "Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita". J. Biol. Chem. 275 (11): 7662–7. doi: 10.1074/jbc.275.11.7662 . PMID   10713076.
7. Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi BZ (December 2000). "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–9. doi: 10.1074/jbc.M004900200 . PMID   10991940.
8. Akiyama H, Fujisawa N, Tashiro Y, Takanabe N, Sugiyama A, Tashiro F (March 2003). "The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2". J. Biol. Chem. 278 (12): 10752–62. doi: 10.1074/jbc.M209856200 . PMID   12522100.
9. Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC   84131 . PMID   10207062.

External links

• Human COPS2 genome location and COPS2 gene details page in the UCSC Genome Browser .
• Human CSN2 genome location and CSN2 gene details page in the UCSC Genome Browser .

Further reading

• Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID   14647295. S2CID   37458780.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. Bibcode:1998CBio....8..919W. doi: 10.1016/S0960-9822(07)00372-7 . PMID   9707402.
• Schaefer L, Beermann ML, Miller JB (1999). "Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien". Genomics. 56 (3): 310–6. doi:10.1006/geno.1998.5728. PMID   10087198.
• Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC   84131 . PMID   10207062.
• Naumann M, Bech-Otschir D, Huang X, Ferrell K, Dubiel W (2000). "COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK". J. Biol. Chem. 274 (50): 35297–300. doi: 10.1074/jbc.274.50.35297 . PMID   10585392.
• Altincicek B, Tenbaum SP, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A (2000). "Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita". J. Biol. Chem. 275 (11): 7662–7. doi: 10.1074/jbc.275.11.7662 . PMID   10713076.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi BZ (2001). "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–9. doi: 10.1074/jbc.M004900200 . PMID   10991940.
• Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain". J. Mol. Biol. 305 (1): 1–9. doi:10.1006/jmbi.2000.4288. PMID   11114242. S2CID   14434381.
• Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC   145508 . PMID   11285227.
• Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci...292.1382L. doi:10.1126/science.1059780. PMID   11337588. S2CID   14224920.
• Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi: 10.1016/S0014-5793(02)03147-2 . PMID   12220626.
• Akiyama H, Fujisawa N, Tashiro Y, Takanabe N, Sugiyama A, Tashiro F (2003). "The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2". J. Biol. Chem. 278 (12): 10752–62. doi: 10.1074/jbc.M209856200 . PMID   12522100.
• Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, Deng XW (2003). "Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex". Plant Cell. 15 (3): 719–31. doi:10.1105/tpc.009092. PMC   150025 . PMID   12615944.
• Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, Huang X, Berse M, Sperling J, Schade R, Dubiel W (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC   151059 . PMID   12628923.