Carboxybiotin decarboxylase

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Carboxybiotin decarboxylase
Identifiers
EC no. 7.2.4.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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NCBI proteins

Carboxybiotin decarboxylase (EC 7.2.4.1, MadB, carboxybiotin protein decarboxylase) is an enzyme with systematic name carboxybiotinyl-(protein) carboxy-lyase. [1] [2] This enzyme catalyses the following chemical reaction

Contents

a carboxybiotinyl-[protein] + n Na+in + H+out CO2 + a biotinyl-[protein] + n Na+out (n = 1--2)

This enzyme is an integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra .

Nomenclature

This enzyme was previously classified as EC 4.3.99.2.

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References

  1. Berg M, Hilbi H, Dimroth P (April 1997). "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function". European Journal of Biochemistry. 245 (1): 103–15. doi: 10.1111/j.1432-1033.1997.00103.x . PMID   9128730.
  2. Dimroth P, Hilbi H (July 1997). "Enzymic and genetic basis for bacterial growth on malonate". Molecular Microbiology. 25 (1): 3–10. doi: 10.1046/j.1365-2958.1997.4611824.x . PMID   11902724.