Chlamydia muridarum

Last updated

Chlamydia muridarum
Scientific classification Red Pencil Icon.png
Domain: Bacteria
Phylum: Chlamydiota
Class: Chlamydiia
Order: Chlamydiales
Family: Chlamydiaceae
Genus: Chlamydia
Species:
C. muridarum
Binomial name
Chlamydia muridarum
Everett et al., 1999 [1]

Chlamydia muridarum is an intracellular bacterial species that at one time belonged to Chlamydia trachomatis . However, C. trachomatis naturally only infects humans and C. muridarum naturally infects only members of the family Muridae (includes both mice and hamsters, Alderton, 1996).

Contents

Two strains of Chlamydia muridarum, MoPn (originally named Nigg) and SFPD, [2] have been isolated from mice and hamsters. Glycogen production by both strains has been demonstrated. The chromosome and extrachromosomal plasmid of MoPn have been sequenced.

Chlamydia muridarum MoPn binds mAbs recognizing Chlamydia trachomatis MOMP vs4 core epitope (T) LNPT (IA). [3] DNA sequence analysis indicates that these mAbs should recognize SFPD and that Chlamydia trachomatis B-serogroup mAbs specific for the vs4 epitope IAGAG should recognize SFPD. [4] MoPn was isolated in 1942 from the lungs of asymptomatic albino Swiss mice and was subsequently shown to be capable of producing disease in mice. [5] SFPD was obtained from a hamster, concurrent with a causative agent of proliferative ileitis. MoPn has been shown to be sensitive to sulfadiazine. In contrast to Chlamydia trachomatis, Chlamydia muridarum lacks a tryptophan operon. [6] Due to this, Chlamydia muridarum responds to interferon gamma (IFN-γ) differently than Chlamydia trachomatis, which effects the degree to which the two different Chlamydia strains are inhibited in infected mice and humans, respectively. [7] [8]

Genome structure

The genome of several strains has been sequenced. [9]

Related Research Articles

<span class="mw-page-title-main">Chlamydia</span> Sexually transmitted infection caused by the bacterium Chlamydia trachomatis

Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. Most people who are infected have no symptoms. When symptoms do appear they may occur only several weeks after infection; the incubation period between exposure and being able to infect others is thought to be on the order of two to six weeks. Symptoms in women may include vaginal discharge or burning with urination. Symptoms in men may include discharge from the penis, burning with urination, or pain and swelling of one or both testicles. The infection can spread to the upper genital tract in women, causing pelvic inflammatory disease, which may result in future infertility or ectopic pregnancy.

<span class="mw-page-title-main">Lymphogranuloma venereum</span> Sexually transmitted disease

Lymphogranuloma venereum is a sexually transmitted disease caused by the invasive serovars L1, L2, L2a, L2b, or L3 of Chlamydia trachomatis.

<i>Chlamydia trachomatis</i> Species of bacterium

Chlamydia trachomatis, commonly known as chlamydia, is a bacterium that causes chlamydia, which can manifest in various ways, including: trachoma, lymphogranuloma venereum, nongonococcal urethritis, cervicitis, salpingitis, pelvic inflammatory disease. C. trachomatis is the most common infectious cause of blindness and the most common sexually transmitted bacterium.

<i>Leptospira</i> Genus of bacteria

Leptospira is a genus of spirochaete bacteria, including a small number of pathogenic and saprophytic species. Leptospira was first observed in 1907 in kidney tissue slices of a leptospirosis victim who was described as having died of "yellow fever".

<i>Chlamydia psittaci</i> Species of bacterium

Chlamydia psittaci is a lethal intracellular bacterial species that may cause endemic avian chlamydiosis, epizootic outbreaks in mammals, and respiratory psittacosis in humans. Potential hosts include feral birds and domesticated poultry, as well as cattle, pigs, sheep, and horses. C. psittaci is transmitted by inhalation, contact, or ingestion among birds and to mammals. Psittacosis in birds and in humans often starts with flu-like symptoms and becomes a life-threatening pneumonia. Many strains remain quiescent in birds until activated by stress. Birds are excellent, highly mobile vectors for the distribution of chlamydia infection, because they feed on, and have access to, the detritus of infected animals of all sorts.

<i>Shigella flexneri</i> Species of bacterium

Shigella flexneri is a species of Gram-negative bacteria in the genus Shigella that can cause diarrhea in humans. Several different serogroups of Shigella are described; S. flexneri belongs to group B. S. flexneri infections can usually be treated with antibiotics, although some strains have become resistant. Less severe cases are not usually treated because they become more resistant in the future. Shigella are closely related to Escherichia coli, but can be differentiated from E.coli based on pathogenicity, physiology and serology.

Chlamydia suis is a member of the genus Chlamydia. C. suis has only been isolated from swine, in which it may be endemic. Glycogen has been detected in Chlamydia suis inclusions in infected swine tissues and in cell culture. C. suis is associated with conjunctivitis, enteritis and pneumonia in swine.

Chlamydia caviae is a bacterium that can be recovered from the conjunctiva of Guinea pigs suffering from ocular inflammation and eye discharge. It is also possible to infect the genital tract of Guinea pigs with C. caviae and elicit a disease that is very similar to human Chlamydia trachomatis infection. C. caviae infects primarily the mucosal epithelium and is not invasive.

Chlamydia pecorum, also known as Chlamydophila pecorum is a species of Chlamydiaceae that originated from ruminants, such as cattle, sheep and goats. It has also infected koalas and swine. C. pecorum strains are serologically and pathogenically diverse.

<span class="mw-page-title-main">Subclinical infection</span> Nearly or completely asymptomatic infection

A subclinical infection—sometimes called a preinfection or inapparent infection—is an infection by a pathogen that causes few or no signs or symptoms of infection in the host. Subclinical infections can occur in both humans and animals. Depending on the pathogen, which can be a virus or intestinal parasite, the host may be infectious and able to transmit the pathogen without ever developing symptoms; such a host is called an asymptomatic carrier. Many pathogens, including HIV, typhoid fever, and coronaviruses such as COVID-19 spread in their host populations through subclinical infection.

<i>Burkholderia thailandensis</i> Species of bacterium

Burkholderia thailandensis is a nonfermenting motile, Gram-negative bacillus that occurs naturally in soil. It is closely related to Burkholderia pseudomallei, but unlike B. pseudomallei, it only rarely causes disease in humans or animals. The lethal inoculum is approximately 1000 times higher than for B. pseudomallei. It is usually distinguished from B. pseudomallei by its ability to assimilate arabinose. Other differences between these species include lipopolysaccharide composition, colony morphology, and differences in metabolism.

<i>Chlamydia</i> (genus) Genus of bacteria

Chlamydia is a genus of pathogenic Gram-negative bacteria that are obligate intracellular parasites. Chlamydia infections are the most common bacterial sexually transmitted diseases in humans and are the leading cause of infectious blindness worldwide.

Fibronectin binding protein A (FnBPA) is a Staphylococcus aureus MSCRAMM cell surface-bound protein that binds to both fibronectin and fibrinogen.

The translocated actin-recruiting phosphoprotein (Tarp) is a protein that may mediate the invasion of epithelial cells by Chlamydia trachomatis using a type three secretion system.

<i>Salmonella enterica <span style="font-style:normal;">subsp.</span> enterica</i> Subspecies of bacterium

Salmonella enterica subsp. enterica is a subspecies of Salmonella enterica, the rod-shaped, flagellated, aerobic, Gram-negative bacterium. Many of the pathogenic serovars of the S. enterica species are in this subspecies, including that responsible for typhoid.

<i>Proteus penneri</i> Species of bacterium

Proteus penneri is a Gram-negative, facultatively anaerobic, rod-shaped bacterium. It is an invasive pathogen and a cause of nosocomial infections of the urinary tract or open wounds. Pathogens have been isolated mainly from the urine of patients with abnormalities in the urinary tract, and from stool. P. penneri strains are naturally resistant to numerous antibiotics, including penicillin G, amoxicillin, cephalosporins, oxacillin, and most macrolides, but are naturally sensitive to aminoglycosides, carbapenems, aztreonam, quinolones, sulphamethoxazole, and co-trimoxazole. Isolates of P. penneri have been found to be multiple drug-resistant (MDR) with resistance to six to eight drugs. β-lactamase production has also been identified in some isolates.

<i>Helicobacter bilis</i> Species of bacterium

Helicobacter bilis is a bacterium in the Helicobacteraceae family, Campylobacterales order. It is a fusiform bacterium with three to 14 multiple bipolar sheathed flagella and periplasmic fibers wrapped around the cell. It is resistant to cephalothin and nalidixic acid, but sensitive to metronidazole. Like Helicobacter hepaticus, it colonizes the bile, liver, and intestine of mice, and is associated with multifocal chronic hepatitis and hepatocellular tumors.

Helicobacter muridarum is a bacterium in the Helicobacteraceae family, Campylobacterales order. It is microaerophilic and helical and was first isolated from the intestinal mucosa of rodents, hence its name. It is characterised by the presence of 9 to 11 periplasmic fibers which appear as concentric helical ridges on the surface of each cell. The cells are motile and have bipolar tufts of 10 to 14 sheathed flagella. These bacteria are nutritionally fastidious and physiologically similar to other Helicobacter species and Wolinella succinogenes, but can be differentiated from these organisms by their unique cellular ultrastructure. ST1T is its type strain.

Mycoplasma penetrans is a species of Gram-positive bacteria. It is pathogenic, though many infected show no symptoms. It is a sexually transmitted disease, though an infant may be infected during birth.

Ehrlichia muris is a species of pathogenic bacteria first isolated from mice, with type strain AS145T. Its genome has been sequenced.

References

  1. Everett, K. D. E.; Bush, R. M.; Andersen, A. A. (1999). "Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms". International Journal of Systematic Bacteriology. 49 (2): 415–440. doi: 10.1099/00207713-49-2-415 . ISSN   0020-7713. PMID   10319462.
  2. Zhang, YX.; Fox, JG.; Ho, Y.; Zhang, L.; Stills, HF.; Smith, TF. (Nov 1993). "Comparison of the major outer-membrane protein (MOMP) gene of mouse pneumonitis (MoPn) and hamster SFPD strains of Chlamydia trachomatis with other Chlamydia strains". Mol Biol Evol. 10 (6): 1327–42. doi: 10.1093/oxfordjournals.molbev.a040079 . PMID   8277858.
  3. Peterson, EM.; Cheng, X.; Markoff, BA.; Fielder, TJ.; de la Maza, LM. (Nov 1991). "Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies". Infect Immun. 59 (11): 4147–53. doi:10.1128/IAI.59.11.4147-4153.1991. PMC   259009 . PMID   1718870.
  4. Batteiger, BE.; Lin, PM.; Jones, RB.; Van Der Pol, BJ. (Jul 1996). "Species-, serogroup-, and serovar-specific epitopes are juxtaposed in variable sequence region 4 of the major outer membrane proteins of some Chlamydia trachomatis serovars". Infect Immun. 64 (7): 2839–41. doi:10.1128/IAI.64.7.2839-2841.1996. PMC   174151 . PMID   8698520.
  5. Nigg, C. (Jan 1942). "An Unidentified Virus Which Produces Pneumonia and Systemic Infection in Mice". Science. 95 (2454): 49–50. Bibcode:1942Sci....95...49N. doi:10.1126/science.95.2454.49-a. PMID   17773453. S2CID   34446808.
  6. Farris, Christina M.; Morrison, Richard P. (Mar 2011). Andrews-Polymenis, H. L. (ed.). "Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model". Infection and Immunity. 79 (3): 986–996. doi:10.1128/IAI.00881-10. ISSN   0019-9567. PMC   3067520 . PMID   21078844.
  7. Farris, Christina M.; Morrison, Richard P. (Mar 2011). Andrews-Polymenis, H. L. (ed.). "Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model". Infection and Immunity. 79 (3): 986–996. doi:10.1128/IAI.00881-10. ISSN   0019-9567. PMC   3067520 . PMID   21078844.
  8. Molecular Medical Microbiology. Elsevier. 2015. doi:10.1016/c2010-1-67744-9. ISBN   9780123971692.
  9. Read TD, et al. (2000). "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39". Nucleic Acids Res. 28 (6): 1397–406. doi:10.1093/nar/28.6.1397. PMC   111046 . PMID   10684935.

Further reading