Chondromyxoid fibroma

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Chondromyxoid fibroma
Specialty Oncology

Chondromyxoid fibroma is a rare type of cartilage tumor [1] which rarely occurs in the skull or skull base. [2]

Most cases are characterised by GRM1 gene fusion or promoter swapping. [3] It can be associated with a translocation at t(1;5)(p13;p13). [4]

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References

  1. Hakan T, Vardar Aker F (July 2008). "Chondromyxoid fibroma of frontal bone: a case report and review of the literature". Turk Neurosurg. 18 (3): 249–53. PMID   18814113.
  2. Thompson AL, Bharatha A, Aviv RI, Nedzelski J, Chen J, Bilbao JM, Wong J, Saad R, Symons SP (July 2009). "Chondromyoid fibroma of the mastoid facial nerve canal mimicking a facial nerve schwannoma". Laryngoscope. 119 (7): 1380–1383. doi:10.1002/lary.20486. PMID   19507235. S2CID   34800452.
  3. Nord KH, Lilljebjörn H, Vezzi F, et al. (2014). "GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma". Nat Genet. 46 (5): 474–7. doi:10.1038/ng.2927. hdl: 1887/104849 . PMID   24658000. S2CID   20990305.
  4. Armah HB, McGough RL, Goodman MA, et al. (2007). "Chondromyxoid fibroma of rib with a novel chromosomal translocation: a report of four additional cases at unusual sites". Diagn Pathol. 2: 44. doi: 10.1186/1746-1596-2-44 . PMC   2203974 . PMID   18036245.