Cobalt-precorrin 5A hydrolase

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Cobalt-precorrin 5A hydrolase
Identifiers
EC no. 3.7.1.12
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Cobalt-precorrin 5A hydrolase (EC 3.7.1.12), CbiG (gene)) is an enzyme with systematic name cobalt-precorrin 5A acylhydrolase. [1] This enzyme catalyses the following chemical reaction

Contents

cobalt-precorrin-5A + H2O cobalt-precorrin-5B + acetaldehyde + 2 H+

This enzyme hydrolyses the ring A acetate delta-lactone of cobalt-precorrin-5A and releases a two-carbon fragment from the macrocyclic corrin ring as acetaldehyde. This is part of the biosynthetic pathway to cobalamin (vitamin B12) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium .

See also

Related Research Articles

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References

  1. ↑ Kajiwara Y, Santander PJ, Roessner CA, Pérez LM, Scott AI (August 2006). "Genetically engineered synthesis and structural characterization of cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway to vitamin B12: definition of the roles of the CbiF and CbiG enzymes". Journal of the American Chemical Society. 128 (30): 9971–8. doi:10.1021/ja062940a. PMID   16866557.
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