Connie C. Lu

Last updated
Connie C. Lu
盧之瑜
Born
Connie Chih Lu
Alma mater Massachusetts Institute of Technology B.S. (2000)
California Institute of Technology Ph.D. (2006)
Scientific career
Fields Inorganic chemistry, Organometallic chemistry, Catalysis
Institutions University of Minnesota (2009-present)
Max Planck Institute for Bioinorganic Chemistry (2006-2009)
Thesis The Chemistry of Tris(phosphino)borate Manganese and Iron Platforms  (2006)
Doctoral advisor Jonas C. Peters
Other academic advisors Karl Wieghardt
Website lu.chem.umn.edu

Connie C. Lu is a Taiwanese-American inorganic chemist and a professor of chemistry at the University of Minnesota, Twin Cities. [1] Lu's research focuses on the synthesis of novel bimetallic coordination complexes, [2] as well as metal-organic frameworks. These molecules and materials are investigated for the catalytic conversion of small molecules like as N2 and CO2 into value-added chemicals like ammonia and methanol. Lu is the recipient of multiple awards for her research, including the National Science Foundation CAREER Award [3] and the Sloan Research Fellowship [4] in 2013, and an Early Career Award from the University of Minnesota's Initiative for Renewable Energy and the Environment in 2010. [5]

Contents

Early life and education

Lu grew up in Miami, Florida, the daughter of immigrants from Taiwan. [6] She studied chemistry at the Massachusetts Institute of Technology, earning her B.S. in 2000. [1] As an undergraduate, she conducted research under Prof. Vernon Ingram on peptides that ameliorate amyloid beta neurotoxicity. [7]

She then went on to graduate studies at the California Institute of Technology, where she studied novel coordination chemistry and small molecule reactivity with Prof. Jonas C. Peters. Lu's doctoral work focused on the reactivity of zwitterionic palladium(II) complexes with CO, ethylene and amines, [8] [9] as well as tetrahedral manganese complexes [10] and reductive cleavage of CO2 with an iron(I) complex. [11] She earned her Ph.D. in 2006, with a thesis entitled The Chemistry of Tris(phosphino)borate Manganese and Iron Platforms. [12]

Lu conducted postdoctoral studies at the Max Planck Institute for Bioinorganic Chemistry from 2006 to 2009, under the mentorship of Prof. Karl Wieghardt. Under Wieghardt, Lu studied first-row transition metal complexes synthesized with redox non-innocent α-iminopyridine ligands. [13] [14] [15] Lu also reported the synthesis and characterization of a chromium iminyl radical complex, using the α-iminopyridine ligand system. [16]

Independent career

A heterobimetallic coordination complex prepared by Lu and coworkers, bearing a quintuple metal-metal bond, with Mn-Cr bond distance of 1.8192(9) A. Manganese-Chromium Quintuple Bond Crystal Structure.png
A heterobimetallic coordination complex prepared by Lu and coworkers, bearing a quintuple metal-metal bond, with Mn-Cr bond distance of 1.8192(9) Å.

In 2009, Lu began her independent career at the University of Minnesota, Twin Cities as an assistant professor in the department of chemistry. [18] She was promoted to associate professor with tenure in 2015, and full professor in 2020. [18]

Her research focuses on the synthesis and characterization of bimetallic complexes, especially those that contain a metal-metal bond. The Lu group has developed a series of trianionic, tripodal ligands that can coordinate two metals at close proximity, allowing for the formation for a metal-metal bond in a coordination complex. [2] The metal-metal bond order can range from bond orders of less than one to a quintuple bond, as between manganese and chromium in a complex reported in 2013, [17] and between two chromium atoms in a complex reported in 2015. [19]

These coordination complexes are also active for catalytic reactions of small molecules, such as the silylation of nitrogen by a dicobalt complex, [20] and alkene hydrogenation by nickel-group 13 element complexes. [21]

Awards

Lu was named an Outstanding Reviewer of the journal Chemical Society Reviews in 2018 [22] and 2019, [23] featured in a 2018 JACS Young Investigators Virtual Issue, [24] and named a Kavli Frontiers of Science Fellow in 2013. [25] She has been honored with invited speaking engagements, as she gave a plenary lecture at a Royal Society of Chemistry Dalton Conference in 2018, [26] and the Association for Cultural Diversity in Chemistry Lecture at the University of Pennsylvania in 2016. [27] In 2017, Lu was invited to be a speaker at the Indo-US Workshop on Organometallic Chemistry [28] and a Inorganic Chemistry Young Outstanding Upcoming speaker at Symposium on Advanced Biological Inorganic Chemistry in Kolkata, India. [29]

Memberships

Lu is a member of the American Chemical Society and the Royal Chemical Society, [18] and has served on the editorial advisory board of Chemical Society Reviews since 2016. [30] She also served on the Inorganic Chemistry editorial advisory board from 2016 to 2018. [18]

Related Research Articles

<span class="mw-page-title-main">Chromium hexacarbonyl</span> Chemical compound

Chromium hexacarbonyl (IUPAC name: hexacarbonylchromium) is a chromium(0) organometallic compound with the formula Cr(CO)6. It is homoleptic complex, which means that all the ligands are identical. It is a white, air-stable solid with a high vapor pressure.

<span class="mw-page-title-main">Robert H. Crabtree</span> British-American chemist

Robert Howard Crabtree is a British-American chemist. He is serving as Conkey P. Whitehead Professor Emeritus of Chemistry at Yale University in the United States. He is a naturalized citizen of the United States. Crabtree is particularly known for his work on "Crabtree's catalyst" for hydrogenations, and his textbook on organometallic chemistry.

In chemistry, a (redox) non-innocent ligand is a ligand in a metal complex where the oxidation state is not clear. Typically, complexes containing non-innocent ligands are redox active at mild potentials. The concept assumes that redox reactions in metal complexes are either metal or ligand localized, which is a simplification, albeit a useful one.

<span class="mw-page-title-main">Liebeskind–Srogl coupling</span>

The Liebeskind–Srogl coupling reaction is an organic reaction forming a new carbon–carbon bond from a thioester and a boronic acid using a metal catalyst. It is a cross-coupling reaction. This reaction was invented by and named after Jiri Srogl from the Academy of Sciences, Czech Republic, and Lanny S. Liebeskind from Emory University, Atlanta, Georgia, USA. There are three generations of this reaction, with the first generation shown below. The original transformation used catalytic Pd(0), TFP = tris(2-furyl)phosphine as an additional ligand and stoichiometric CuTC = copper(I) thiophene-2-carboxylate as a co-metal catalyst. The overall reaction scheme is shown below.

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Gregory S. Girolami is the William H. and Janet G. Lycan Professor of Chemistry at the University of Illinois at Urbana-Champaign. His research focuses on the synthesis, properties, and reactivity of new inorganic, organometallic, and solid state species. Girolami has been elected a fellow of the American Association for the Advancement of Science, the Royal Society of Chemistry, and the American Chemical Society.

<span class="mw-page-title-main">Organotantalum chemistry</span> Chemistry of compounds containing a carbon-to-tantalum bond

Organotantalum chemistry is the chemistry of chemical compounds containing a carbon-to-tantalum chemical bond. A wide variety of compound have been reported, initially with cyclopentadienyl and CO ligands. Oxidation states vary from Ta(V) to Ta(-I).

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Cobalt(II)–porphyrin catalysis is a process in which a Co(II) porphyrin complex acts as a catalyst, inducing and accelerating a chemical reaction.

The Mukaiyama hydration is an organic reaction involving formal addition of an equivalent of water across an olefin by the action of catalytic bis(acetylacetonato)cobalt(II) complex, phenylsilane and atmospheric oxygen to produce an alcohol with Markovnikov selectivity.

<span class="mw-page-title-main">Phosphenium</span> Divalent cations of phosphorus

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<span class="mw-page-title-main">Nontrigonal pnictogen compounds</span>

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Julia A. Kovacs is an American chemist specializing in bioinorganic chemistry. She is professor of chemistry at the University of Washington. Her research involves synthesizing small-molecule mimics of the active sites of metalloproteins, in order to investigate how cysteinates influence the function of non-heme iron enzymes, and the mechanism of the oxygen-evolving complex (OEC).

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<span class="mw-page-title-main">Paula Diaconescu</span> Inorganic chemist

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Suzanne Cathleen Bart an American chemist who is a professor of inorganic chemistry at Purdue University. Her group's research focuses on actinide organometallic chemistry, and especially the characterization of low-valent organouranium complexes, actinide complexes with redox-active ligands, and discovery of new reactions that utilize these compounds. Bart's research has applications in the development of carbon-neutral fuel sources and the remediation of polluted sites.

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References

  1. 1 2 "Connie C. Lu | Department of Chemistry | College of Science and Engineering". cse.umn.edu. Retrieved 2021-06-04.
  2. 1 2 Eisenhart, Reed J.; Clouston, Laura J.; Lu, Connie C. (2015-10-22). "Configuring Bonds between First-Row Transition Metals". Accounts of Chemical Research. 48 (11): 2885–2894. doi:10.1021/acs.accounts.5b00336. ISSN   0001-4842. PMID   26492331.
  3. ↑ "NSF Award Search: Award # 1254621 - CAREER: Configuring New Bonds Between First-row Transition Metals". www.nsf.gov. Retrieved 2021-06-04.
  4. ↑ "Past Fellows | Alfred P. Sloan Foundation". sloan.org. Archived from the original on 2018-03-14. Retrieved 2021-06-07.
  5. ↑ "Professors Lu and Massari awarded Early Career Grants from the Initiative for Renewable Energy and the Environment". University of Minnesota Chemistry Department. May 5, 2010. Archived from the original on 2010-06-11. Retrieved 2021-06-07.
  6. ↑ Pattison, Kermit. "Connie Lu: Changing times | College | College of Science and Engineering". cse.umn.edu. Archived from the original on 2019-02-27. Retrieved 2021-06-07.
  7. ↑ Blanchard, Barbara J.; Hiniker, Anne E.; Lu, Connie C.; Margolin, Yelena; Yu, Amy S.; Ingram, Vernon M. (2000-01-01). "Elimination of Amyloid β Neurotoxicity". Journal of Alzheimer's Disease. 2 (2): 137–149. doi:10.3233/JAD-2000-2214. ISSN   1387-2877. PMID   12214104.
  8. ↑ Lu, Connie C.; Peters, Jonas C. (2002). "Catalytic Copolymerization of CO and Ethylene with a Charge Neutral Palladium(II) Zwitterion". Journal of the American Chemical Society. 124 (19): 5272–5273. doi:10.1021/ja017011s. ISSN   0002-7863. PMID   11996560.
  9. ↑ Lu, Connie C.; Peters, Jonas C. (2004). "Synthetic, Structural, and Mechanistic Aspects of an Amine Activation Process Mediated at a Zwitterionic Pd(II) Center". Journal of the American Chemical Society. 126 (48): 15818–15832. doi:10.1021/ja046415s. ISSN   0002-7863. PMID   15571407.
  10. ↑ Lu, Connie C.; Peters, Jonas C. (2006). "Pseudotetrahedral Manganese Complexes Supported by the Anionic Tris(phosphino)borate Ligand [PhBPiPr3]". Inorganic Chemistry. 45 (21): 8597–8607. doi:10.1021/ic060735q. ISSN   0020-1669. PMC   2920598 . PMID   17029370.
  11. ↑ Lu, Connie C.; Saouma, Caroline T.; Day, Michael W.; Peters, Jonas C. (2006-12-16). "Fe(I)-Mediated Reductive Cleavage and Coupling of CO2: An FeII(μ-O,μ-CO)FeII Core". Journal of the American Chemical Society. 129 (1): 4–5. doi:10.1021/ja065524z. ISSN   0002-7863. PMC   2888261 . PMID   17199260.
  12. ↑ Lu, Connie Chih (2006). The Chemistry of Tris(phosphino)borate Manganese and Iron Platforms (Ph.D. thesis). California Institute of Technology.
  13. ↑ Lu, Connie C.; Bill, Eckhard; Weyhermüller, Thomas; Bothe, Eberhard; Wieghardt, Karl (2007-09-01). "The Monoanionic π-Radical Redox State of α-Iminoketones in Bis(ligand)metal Complexes of Nickel and Cobalt". Inorganic Chemistry. 46 (19): 7880–7889. doi:10.1021/ic7008094. ISSN   0020-1669. PMID   17715916.
  14. ↑ Lu, Connie C.; Bill, Eckhard; Weyhermüller, Thomas; Bothe, Eberhard; Wieghardt, Karl (2008). "Neutral Bis(α-iminopyridine)metal Complexes of the First-Row Transition Ions (Cr, Mn, Fe, Co, Ni, Zn) and Their Monocationic Analogues: Mixed Valency Involving a Redox Noninnocent Ligand System". Journal of the American Chemical Society. 130 (10): 3181–3197. doi:10.1021/ja710663n. ISSN   0002-7863. PMID   18284242.
  15. ↑ Lu, Connie C.; Weyhermüller, Thomas; Bill, Eckhard; Wieghardt, Karl (2009-05-28). "Accessing the Different Redox States of α-Iminopyridines within Cobalt Complexes". Inorganic Chemistry. 48 (13): 6055–6064. doi:10.1021/ic9004328. ISSN   0020-1669. PMID   20507103.
  16. ↑ Lu, Connie C.; DeBeer George, Serena; Weyhermüller, Thomas; Bill, Eckhard; Bothe, Eberhard; Wieghardt, Karl (2008). "An Electron-Transfer Series of High-Valent Chromium Complexes with Redox Non-Innocent, Non-Heme Ligands". Angewandte Chemie International Edition. 47 (34): 6384–6387. doi:10.1002/anie.200800669. ISSN   1521-3773. PMID   18618881.
  17. 1 2 Clouston, Laura J.; Siedschlag, Randall B.; Rudd, P. Alex; Planas, Nora; Hu, Shuxian; Miller, Adam D.; Gagliardi, Laura; Lu, Connie C. (2013-08-23). "Systematic Variation of Metal–Metal Bond Order in Metal–Chromium Complexes". Journal of the American Chemical Society. 135 (35): 13142–13148. doi:10.1021/ja406506m. ISSN   0002-7863. PMID   23901938.
  18. 1 2 3 4 "Connie Lu promoted to professor | Department of Chemistry | College of Science and Engineering". cse.umn.edu. Retrieved 2021-06-04.
  19. ↑ Eisenhart, Reed J.; Rudd, P. Alex; Planas, Nora; Boyce, David W.; Carlson, Rebecca K.; Tolman, William B.; Bill, Eckhard; Gagliardi, Laura; Lu, Connie C. (2015-07-13). "Pushing the Limits of Delta Bonding in Metal–Chromium Complexes with Redox Changes and Metal Swapping". Inorganic Chemistry. 54 (15): 7579–7592. doi:10.1021/acs.inorgchem.5b01163. ISSN   0020-1669. PMC   5960016 . PMID   26168331.
  20. ↑ Siedschlag, Randall B.; Bernales, Varinia; Vogiatzis, Konstantinos D.; Planas, Nora; Clouston, Laura J.; Bill, Eckhard; Gagliardi, Laura; Lu, Connie C. (2015-04-06). "Catalytic Silylation of Dinitrogen with a Dicobalt Complex". Journal of the American Chemical Society. 137 (14): 4638–4641. doi:10.1021/jacs.5b01445. ISSN   0002-7863. PMID   25799204.
  21. ↑ Cammarota, Ryan C.; Lu, Connie C. (2015-09-24). "Tuning Nickel with Lewis Acidic Group 13 Metalloligands for Catalytic Olefin Hydrogenation". Journal of the American Chemical Society. 137 (39): 12486–12489. doi:10.1021/jacs.5b08313. ISSN   0002-7863. PMID   26378748.
  22. ↑ "Outstanding Reviewers for Chemical Society Reviews in 2018". Chemical Society Reviews. 48 (8): 2273. 2019-04-15. doi:10.1039/C9CS90026H. ISSN   1460-4744. S2CID   96435297.
  23. ↑ "Outstanding Reviewers for Chemical Society Reviews in 2019". Chemical Society Reviews. 49 (11): 3243. 2020-06-08. doi:10.1039/D0CS90047H. ISSN   1460-4744. S2CID   219173084.
  24. ↑ "JACS Young Investigators Virtual Issue". pubs.acs.org. Archived from the original on 2021-04-13. Retrieved 2021-06-07.
  25. ↑ "Connie Lu". www.nasonline.org. Retrieved 2021-06-07.
  26. ↑ "Dalton 2018". www.rsc.org. Retrieved 2021-06-07.
  27. ↑ "ACDC Event Photos". acdc.chem.upenn.edu. Retrieved 2021-06-07.
  28. ↑ "Virtual Issue: Celebrating Organic and Inorganic Chemistry Published by Authors in India". ACS Axial. 2017-12-06. Retrieved 2021-06-07.
  29. ↑ "Speakers - Symposium on Advanced Biological Inorganic Chemistry". January 7, 2017. Archived from the original on 2016-09-08.
  30. ↑ "Chemical Society Reviews journal". Royal Society of Chemistry. Retrieved 2021-06-07.
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