Gene therapy is a medical technology which aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells.
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or reduction in its function. In combination with other genetic mutations, this could allow the cell to grow abnormally. The loss of function for these genes may be even more significant in the development of human cancers, compared to the activation of oncogenes.
Pyruvate dehydrogenase deficiency is a rare neurodegenerative disorder associated with abnormal mitochondrial metabolism. PDCD is a genetic disease resulting from mutations in one of the components of the pyruvate dehydrogenase complex (PDC). The PDC is a multi-enzyme complex that plays a vital role as a key regulatory step in the central pathways of energy metabolism in the mitochondria. The disorder shows heterogeneous characteristics in both clinical presentation and biochemical abnormality.
Antiviral Therapy is a peer-reviewed medical journal published by International Medical Press. It publishes primary papers and reviews on all aspects of the clinical development of antiviral drugs, including clinical trial results, drug resistance, viral diagnostics, drug safety, pharmacoepidemiology, and vaccines. Antiviral Therapy is an official publication of the International Society for Antiviral Research.
Clinical and Vaccine Immunology (CVI) was a peer-reviewed journal published by the American Society for Microbiology. CVI enhances our understanding of the immune response in health and disease by showcasing important clinically relevant research, including new animal models for human immunologic diseases, viral immunology, immunopathogenesis, and clinical laboratory immunology. In particular, the journal highlights important discoveries in immunization and vaccine research, such as the development and evaluation of vaccines, human and animal immune responses to vaccines, vaccine vectors, adjuvants and immunomodulators, quantitative assays of vaccine efficacy, and clinical trials. The journal publishes primary research articles, editorials, commentaries, minireviews, and case reports. Articles are freely accessible after six months. Through its "Global Outreach Program", free online access is available to qualified microbiologists in eligible developing countries.
Bone Marrow Transplantation is a peer-reviewed medical journal covering transplantation of bone marrow in humans. It is published monthly by Nature Research. The scope of the journal includes stem cell biology, transplantation immunology, translational research, and clinical results of specific transplant protocols.
The Journal of Receptors and Signal Transduction is a peer-reviewed scientific journal that publishes laboratory and clinical studies, reviews, and brief communications on biological receptors and associated signal transduction pathways for ligands involved in the regulation of central and peripheral tissues and cells. It is published by Informa. The editors in chief are Alex N. Eberle and Terrence Kenakin.
Genes to Cells is a peer-reviewed scientific journal that publishes original research on the molecular mechanisms of biological events. The journal has been published since 1996 by Wiley-Blackwell on behalf of the Molecular Biology Society of Japan.
Brain Injury is a monthly, peer-reviewed, medical journal published by Taylor & Francis. Furthermore, it is the official journal of the International Brain Injury Association (IBIA). The chief editors are Jeffrey Kreutzer and Nathan Zasler.
Cytotherapy is a peer-reviewed medical journal covering the areas of cell and gene therapy. The journal was established in 1999 and the Senior Editor is Donald G. Phinney. It is published by Elsevier on behalf of the International Society for Cell & Gene Therapy (ISCT).
Physiotherapy: Theory and Practice is a peer-reviewed medical journal covering research in physiotherapy. It is published 8 times a year by Informa. The journal was established in 1985 and the editor-in-chief is Scott Hasson.
Mechanisms of Development is a peer-reviewed scientific journal covering all aspects of developmental biology. It is the official journal of the International Society of Developmental Biologists and is published by Elsevier. The journal was established in 1972 as Cell Differentiation and was renamed Cell Differentiation and Development in 1988. It acquired its current name in December 1990. The editor-in-chief is D. Wilkinson. A separate section of the journal, Gene Expression Patterns, covers research on cloning and gene expression. In 2020 the journal became Cells & Development with the subtitle: 'Cell and Developmental Biology and their Quantitative Approaches'.
Neural Regeneration Research is a peer-reviewed scientific journal covering research on neuroregeneration and stem cells. Topics covered include neural stem cells, neural tissue engineering, gene therapy, and minimally-invasive treatment of neurodegenerative diseases. It was established in 2006 and the editors in chief are Kwok-Fai So and Xiao-Ming Xu. The journal publishes the following types of papers: research and reports, techniques and methods, investigation and analysis, meta-analyses and reviews, evidence-based case reports, and perspectives.
Current HIV Research is a peer-reviewed scientific journal focusing on HIV/AIDS research, established in 2003. The journal is edited by Yuntao Wu and is published by Bentham Science Publishers. It has an impact factor of 1.581
Current Alzheimer Research is a peer-reviewed medical journal covering the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer's disease.
Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses and those that use naked DNA or DNA complexes.
Drugs & Aging is a monthly peer-reviewed medical journal published by Springer Nature under their Adis International imprint. It contains primarily review articles covering optimum use of drug therapies in older adults.
Gene therapy for osteoarthritis is the application of gene therapy to treat osteoarthritis (OA). Unlike pharmacological treatments which are administered locally or systemically as a series of interventions, gene therapy aims to establish sustained therapeutic effect after a single, local injection.
Expert Review of Anti-infective Therapy is a monthly peer-reviewed medical journal publishing review articles and original papers on all aspects of anti-infective therapy. The journal was established in 2003 and is published by Informa.
Current Drug Metabolism is a peer-reviewed medical journal covering the study of drug metabolism. It was established in 2000 and is published 10 times per year by Bentham Science Publishers. The editor-in-chief is Ming Hu. According to the Journal Citation Reports, the journal has a 2019 impact factor of 2.960.
