David Edwards (engineer)

Last updated
David A. Edwards
David Edwards.jpg
Born
David A. Edwards

(1961-04-06)April 6, 1961
Alma mater Michigan Technological University, BS
Illinois Institute of Technology, PhD
Scientific career
Fields Biomedical engineering
Institutions Harvard University
Website davidideas.com

David A. Edwards (born April 6, 1961) is an American biomedical engineer, and the founder of Sensory Cloud. [1] [2] He was the Gordon McKay Professor of the Practice of Biomedical Engineering at Harvard University. [3] [4]

Contents

Edwards designs inhalable medicines, vaccines and victuals. [5] [6] [7]

In 2001, Edwards was elected a member of the National Academy of Engineering for transfer of scientific principles of engineering to industry, including invention and commercial development of a novel, generic aerosol drug-delivery system.

Education

Edwards studied chemical engineering, receiving a BS from Michigan Technological University in the field in 1983, and a PhD in 1987 from the Illinois Institute of Technology. [8] [9]

Career

Between 1987 and 1995, Edwards held a postdoctoral and lectureship at the Technion in Israel and the Massachusetts Institute of Technology. [10] [11] While at MIT, Robert Langer, a professor at MIT, encouraged Edwards to develop an efficient way for inhalers to deliver medicine to the lungs. [12] Edwards joined the Pennsylvania State University faculty as an Associate Professor of Chemical Engineering in 1995, where he continued to research ways to make medicine inhalable. [13] [14] In 1997, Science published his study on a new type of inhalable aerosol that efficiently delivered drugs to the lungs. [15] [16] Edwards left academia in 1998 when he and Langer founded Advanced Inhalation Research (AIR); the startup was purchased a year later by Alkermes for $114 million. [17] [18] He returned to academia in 2002, joining the Harvard faculty. [19]

Edwards' scientific work in biomedical engineering concerns the research and development of drug delivery platforms for treating infectious diseases in the developing world.[ citation needed ] He was a founder of Advanced Inhalation Research, now part of Alkermes, Inc.,[ citation needed ] of Pulmatrix,[ citation needed ] and of Medicine in Need, an international non-governmental organization aimed at developing new drugs and vaccines for diseases of poverty, such as tuberculosis. [20] [21]

In 2020, Edwards founded the company Sensory Cloud. Sensory Cloud released a nasal inhalable product intended to reduce infected air droplets from viruses like SARS-CoV-2, a strain of coronavirus known to cause COVID-19. [22] [23]

In a February 2021 study in the Proceedings of the National Academy of Sciences of the United States of America , Edwards and his colleagues posited that "exhaled aerosol increases with COVID-19 infection, age, and obesity". [24] [25]

Le Laboratoire

In 2007, Edwards opened "Le Lab" as a space for artists, designers, scientists, and the general public to meet for exhibitions, performances, and discussions in Paris, [26] [27] and then he moved it to 650 East Kendall Street in the Kendall Square area of Cambridge, Massachusetts in 2014. [28] [29] [30] Major exhibitions by artists such as Mark Dion [31] [32] and artist/engineer Chuck Hoberman [33] [34] were shown, as well as innovations developed by Edwards, his associates, and his students. Some of his food-related inventions were available for purchase at Cafe ArtScience, an innovative restaurant associated with Le Laboratoire Cambridge. [35] In December 2019, it was announced that Cafe ArtScience was closing after 5 years of operation, and would be replaced by a new restaurant, called "Senses". [36]

However, the COVID-19 pandemic disrupted these plans, and as of 2022, both the restaurant and Le Laboratoire Cambridge appear to be inactive or closed, either temporarily or permanently.

Personal life

Edwards, his wife and three children have lived alternately in Boston and Paris. [37]

Publications

Related Research Articles

<span class="mw-page-title-main">Cambridge, Massachusetts</span> City in Massachusetts, United States

Cambridge is a city in Middlesex County, Massachusetts, United States. It is a suburb in the Greater Boston metropolitan area, located directly across the Charles River from Boston. The city's population as of the 2020 U.S. census was 118,403, making it the most populous city in the county, the fourth-largest in Massachusetts behind Boston, Worcester, and Springfield, and ninth-most populous in New England. The city was named in honor of the University of Cambridge in Cambridge, England, which was an important center of the Puritan theology that was embraced by the town's founders.

<span class="mw-page-title-main">Massachusetts Institute of Technology</span> Private university in Cambridge, Massachusetts, US

The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a significant role in the development of many areas of modern technology and science.

<span class="mw-page-title-main">Inhalation</span> Flow of the respiratory current into an organism

Inhalation happens when air or other gases enter the lungs.

<span class="mw-page-title-main">Nebulizer</span> Drug delivery device

In medicine, a nebulizer or nebuliser is a drug delivery device used to administer medication in the form of a mist inhaled into the lungs. Nebulizers are commonly used for the treatment of asthma, cystic fibrosis, COPD and other respiratory diseases or disorders. They use oxygen, compressed air or ultrasonic power to break up solutions and suspensions into small aerosol droplets that are inhaled from the mouthpiece of the device. An aerosol is a mixture of gas and solid or liquid particles.

<span class="mw-page-title-main">MIT Press</span> University press in Cambridge, Massachusetts

The MIT Press is the university press of the Massachusetts Institute of Technology (MIT), a private research university in Cambridge, Massachusetts. The MIT Press publishes a number of academic journals and has been a pioneer in the Open Access movement in academic publishing.

<span class="mw-page-title-main">Robert S. Langer</span> American scientist

Robert Samuel Langer Jr. FREng is an American biotechnologist, businessman, chemical engineer, chemist, and inventor. He is one of the nine Institute Professors at the Massachusetts Institute of Technology.

<span class="mw-page-title-main">Metered-dose inhaler</span> Device that helps deliver a specific amount of medication to the lungs

A metered-dose inhaler (MDI) is a device that delivers a specific amount of medication to the lungs in the form of a short burst of aerosolized medicine that is usually self-administered by the patient via inhalation. It is the most commonly used delivery system for treating asthma, chronic obstructive pulmonary disease (COPD) and other respiratory diseases. The medication in a metered dose inhaler is most commonly a bronchodilator, corticosteroid or a combination of both for treating asthma and COPD. Other medications less commonly used but also administered by MDI are mast cell stabilizers, such as cromoglicate or nedocromil.

<span class="mw-page-title-main">MIT Museum</span> Science museum in Cambridge, Massachusetts

The MIT Museum, founded in 1971, is located at the Massachusetts Institute of Technology in Cambridge, Massachusetts. It hosts collections of holography, technology-related artworks, artificial intelligence, architecture, robotics, maritime history, and the history of MIT. Its holography collection of 1800 pieces is the largest in the world, though only a few selections from it are usually exhibited. As of 2023, works by the kinetic artist Arthur Ganson are the largest long-running displays. There is a regular program of temporary special exhibitions, often on the intersections of art and technology.

<span class="mw-page-title-main">History of the Massachusetts Institute of Technology</span>

The history of the Massachusetts Institute of Technology can be traced back to the 1861 incorporation of the "Massachusetts Institute of Technology and Boston Society of Natural History" led primarily by William Barton Rogers.

<span class="mw-page-title-main">Harvard John A. Paulson School of Engineering and Applied Sciences</span> Engineering school of Harvard University in Cambridge, Massachusetts

The Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) is the engineering school within Harvard University's Faculty of Arts and Sciences, offering degrees in engineering and applied sciences to graduate students admitted directly to SEAS, and to undergraduates admitted first to Harvard College. Previously the Lawrence Scientific School and then the Division of Engineering and Applied Sciences, the Paulson School assumed its current structure in 2007. David C. Parkes has been its dean since 2023.

<span class="mw-page-title-main">Leo Rafael Reif</span> Venezuelan-born American electrical engineer, writer and academic administrator (born 1950)

Leo Rafael Reif is a Venezuelan American electrical engineer and academic administrator. He previously served as the 17th president of the Massachusetts Institute of Technology from 2012 to 2022, provost of the institute from 2005 to 2012, and dean of the institute's EECS department from 2004 to 2005.

<span class="mw-page-title-main">Indacaterol</span> Chemical compound

Indacaterol is an ultra-long-acting beta-adrenoceptor agonist developed by Novartis. It needs to be taken only once a day, unlike the related drugs formoterol and salmeterol. It is licensed only for the treatment of chronic obstructive pulmonary disease (COPD). It is delivered as an aerosol formulation through a dry powder inhaler.

<span class="mw-page-title-main">Donald E. Ingber</span> American cell biologist and bioengineer (born 1956)

Donald E. Ingber is an American cell biologist and bioengineer. He is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. He is also a member of the American Institute for Medical and Biological Engineering, the National Academy of Engineering, the National Academy of Medicine, the National Academy of Inventors, and the American Academy of Arts and Sciences.

Elazer R. Edelman is an American engineer, scientist and cardiologist. He is the Edward J. Poitras Professor in Medical Engineering and Science at the Massachusetts Institute of Technology (MIT), Professor of Medicine at Harvard Medical School and at Brigham and Women's Hospital (BWH), and a practicing cardiologist at BWH. He is the director of MIT's Institute for Medical Engineering and Science (IMES), the Harvard-MIT Biomedical Engineering Center, and the MIT Clinical Research Center. He is also the Program Director of the MIT Graduate Education in Medical Sciences program within the Harvard-MIT Division of Health Sciences and Technology.

<span class="mw-page-title-main">Hugo Van Vuuren</span> South African American entrepreneur and investor (born 1984)

Hugo Van Vuuren is a South African American entrepreneur and investor. An expert-in-residence at the Harvard School of Engineering and Applied Sciences, he is the co-founder of Work-Bench, an early stage enterprise technology venture fund.

Omid Farokhzad is an Iranian-American physician, scientist, and entrepreneur in the development of nanomedicines. Farokhzad is a Professor of Anesthesiology at Harvard Medical School. Omid Farokhzad is the Chair, Chief Executive Officer and co-founder for Seer, a company focused on deep, unbiased proteomics analysis at scale. The Boston Globe selected him among the top innovators in Massachusetts and the Boston Business Journal selected him among the Health Care Champions for his innovations.

<span class="mw-page-title-main">Bina Venkataraman</span> American science policy expert, author and journalist

Bina Venkataraman is an American science policy expert, author, and journalist. She is currently a Columnist at The Washington Post. She previously served as the Editorial Page Editor of The Boston Globe and as a senior advisor for Climate Change Innovation under President Barack Obama's administration. She also advised the President's Council of Advisors on Science and Technology and has taught at MIT and the Harvard Kennedy School.

<span class="mw-page-title-main">Linsey Marr</span> American scientist

Linsey Chen Marr is an American scientist who is the Charles P. Lunsford Professor of Civil and Environmental Engineering at Virginia Tech. Her research considers the interaction of nanomaterials and viruses with the atmosphere. During the COVID-19 pandemic Marr studied how SARS-CoV-2 and other airborne pathogens could be transported in air. In 2023, she was elected to the National Academy of Engineering and named a MacArthur Fellow.

<span class="mw-page-title-main">Pulmonary drug delivery</span> Route of administration by inhalation

Pulmonary drug delivery is a route of administration in which patients use an inhaler to inhale their medications and drugs are absorbed into the bloodstream via the lung mucous membrane. This technique is most commonly used in the treatment of lung diseases, for example, asthma and chronic obstructive pulmonary disease (COPD). Different types of inhalers include metered-dose inhalers (MDI), dry powder inhalers (DPI), soft mist inhalers (SMI) and nebulizers. The rate and efficacy of pulmonary drug delivery are affected by drug particle properties, breathing patterns and respiratory tract geometry.

The Wyss Institute for Biologically Inspired Engineering is a cross-disciplinary research institute at Harvard University focused on bridging the gap between academia and industry by drawing inspiration from nature's design principles to solve challenges in health care and the environment. It is focused on the field of biologically inspired engineering to be distinct from bioengineering and biomedical engineering. The institute also has a focus on applications, intellectual property generation, and commercialization.

References

  1. Osgood, Charles; Braver, Rita (27 September 2015). "Does a degree in chemical engineering guarantee that its holder will enjoy the sweet smell of success?". CBS Sunday Morning. Retrieved 23 September 2020.
  2. Pelekanos, Adelle C. (Spring 2008). "Creativity after Google" (PDF). New York Academy of Sciences Magazine. Retrieved 25 September 2020.
  3. Bradt, Steve (13 March 2008). "Inhaled TB vaccine more effective than traditional shot". The Harvard Gazette . Retrieved 23 September 2020.
  4. Etherington, Darrell (8 July 2020). "Harvard biomedical engineering professor to launch nasal spray that could reduce COVID-19 transmission risk". TechCrunch . Retrieved 23 September 2020.
  5. Lazar, Kay (10 April 2009). "Need a Puff of Chocolate? Inhaler Delivers Calorie-free Mist into Your Mouth". The Boston Globe . Retrieved 23 September 2020.
  6. Wilson, Mark (8 July 2020). "Harvard professor develops a $50 nasal spray to thwart the spread of COVID-19". Fast Company. Retrieved 23 September 2020.
  7. Edwards, David A.; Hanes, Justin; Caponetti, Giovanni; Hrkach, Jeffrey; Ben-Jebria, Abdelaziz; Eskew, Mary Lou; Mintzes, Jeffrey; Deaver, Daniel; Lotan, Noah; Langer, Robert (20 June 1997). "Large Porous Particles for Pulmonary Drug Delivery". Science. 276 (5320): 1868–1872. doi:10.1126/science.276.5320.1868. PMID   9188534.
  8. Osgood, Charles; Braver, Rita (27 September 2015). "Does a degree in chemical engineering guarantee that its holder will enjoy the sweet smell of success?". CBS Sunday Morning. Retrieved 23 September 2020.
  9. Schmadeke, Steve (10 April 2009). "A whiff of innovation--and chocolate". Chicago Tribune. Retrieved 24 September 2020.
  10. "The Alan S. Michaels Distinguished Lectureship in Medical and Biological Engineering – 2006". MIT. Retrieved 25 September 2020.
  11. Legg, Heidi (29 September 2015). "The Scent of a Cyborg". TheEditorial. Retrieved 25 September 2020.
  12. Aoki, Naomi (25 May 2003). "MIT Scientist Sees Science As Means to Change the World and He Has". The Boston Globe.
  13. Aoki, Naomi (25 May 2003). "MIT Scientist Sees Science As Means to Change the World and He Has". The Boston Globe.
  14. "The Alan S. Michaels Distinguished Lectureship in Medical and Biological Engineering – 2006". MIT. Retrieved 25 September 2020.
  15. Scripps News Service (20 June 1997). "New aerosol particle helps fight lung disorders". Deseret News . Retrieved 29 September 2020.
  16. Edwards, David; Hanes, J; Caponetti, G; Hrkach, J; Ben-Jebria, A; Eskew, M.L.; Mintzes, J; Deaver, D; Lotan, N; Langer, R (20 June 1997). "Large porous particles for pulmonary drug delivery". Science. 276 (5320): 1868–1871. doi:10.1126/science.276.5320.1868. PMID   9188534.
  17. Kirsner, Scott (3 March 2013). "Harvard dreamer looks for ways to link art, science, and commerce: Innovation Economy". The Boston Globe. Retrieved 23 September 2020.
  18. Aoki, Naomi (25 May 2003). "MIT Scientist Sees Science As Means to Change the World and He Has". The Boston Globe.
  19. "The Alan S. Michaels Distinguished Lectureship in Medical and Biological Engineering – 2006". MIT. Retrieved 25 September 2020.
  20. "Chutzpah Science", Forbes , May 25, 2005.
  21. "Nose Spray May Slow Spread of Germs", Fox News, November 30, 2004.
  22. Wilson, Mark (8 July 2020). "Harvard professor develops a $50 nasal spray to thwart the spread of COVID-19". Fast Company . Retrieved 23 September 2020.
  23. "The Best Inventions of 2020: 100 innovations changing how we live". Time . 19 November 2020. Retrieved 25 August 2021.
  24. Edwards, David (23 February 2021). "Exhaled aerosol increases with COVID-19 infection, age, and obesity". Proceedings of the National Academy of Sciences of the United States of America . 118 (8): e2021830118. Bibcode:2021PNAS..11821830E. doi: 10.1073/pnas.2021830118 . PMC   7923364 . PMID   33563754.
  25. Hussein, Tareq; Löndahl, Jakob; Thuresson, Sara; Alsved, Malin; Al-Hunaiti, Afnan; Saksela, Kalle; Aqel, Hazem; Junninen, Heikki; Mahura, Alexander; Kulmalla, Markku (12 March 2021). "Indoor Model Simulation for COVID-19 Transport and Exposure". Int. J. Environ. Res. Public Health. 18 (6): 2927. doi: 10.3390/ijerph18062927 . PMC   7999367 . PMID   33809366.
  26. Dessent, Blaire. "December 2007, Le Laboratoire". Whitehot Magazine of Contemporary Art. Retrieved 2022-12-31.
  27. Kirsner, Scott (April 1, 2013). "Accelerating art, science in Lab Cambridge". Boston Globe. Retrieved 2023-01-01.
  28. "Le Laboratoire Cambridge". C.E. Floyd. C.E. Floyd Company, PBC. Retrieved 2022-12-31.
  29. Zoia, Gabriella (5 November 2014). "Le Laboratoire creates interactive space for groundbreaking innovation in art, science". The Tufts Daily. Retrieved 2023-01-24.
  30. Lau, Cat (April 24, 2017). "SPACES – Le Laboratoire Cambridge". Polyfield Magazine. Retrieved 2023-01-24.
  31. Gayla, Marella A (November 5, 2015). "The Trouble with Jellyfish". The Harvard Crimson. Retrieved 2022-12-31.
  32. "'The Trouble with Jellyfish'". Harvard Gazette. Harvard University. 26 October 2015. Retrieved 2022-12-31.
  33. Phongsirivech, Pimploy (26 October 2016). "See Transformable Structures at Le Lab Cambridge". Boston Magazine. Retrieved 2023-01-01.
  34. "10° (Ten Degrees)". Hoberman Associates. Retrieved 2023-01-01.
  35. Jiang, Nancy (September 19, 2019). "Cambridge Café ArtScience explores the future of food". The Daily Free Press. Retrieved 2023-01-01.
  36. Blumenthal, Rachel Leah (20 December 2019). "Cafe Artscience Is Closing in Cambridge After Five Years". Eater Boston. Retrieved 2023-01-01.
  37. Kirsner, Scott (3 March 2013). "Harvard dreamer looks for ways to link art, science, and commerce: Innovation Economy". The Boston Globe. Retrieved 23 September 2020.