Denaverine

Denaverine

Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	Gr 1 (Germany)
Routes of administration	intramuscular injection, suppositories
ATCvet code	QG02CX90 ( WHO )
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	8% (suppositories), 37% (oral solution)
Metabolism	mainly hepatic, at least 11 metabolites
Elimination half-life	34 hours
Identifiers
IUPAC name 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
CAS Number	3579-62-2  Y 3321-06-0 (hydrochloride)
PubChem CID	71130
ChemSpider	64278  N
UNII	O14NF38MTL
KEGG	D07787  Y
ChEMBL	ChEMBL1614656  N
CompTox Dashboard (EPA)	DTXSID10189315
Chemical and physical data
Formula	C24H33NO3
Molar mass	383.532 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C
InChI InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3 N Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during parturition. ^[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms. ^[2]

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects. ^[3]

References

1. Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
2. Dootz H, Kuhlmann A, Hoffmann K, eds. (2005). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN   3-87193-306-6.
3. Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN   978-3-7741-9846-3.