Dobesilic acid

Dobesilic acid
Names
	IUPAC name 2,5-Dihydroxybenzenesulfonic acid
	Other names Hydroquinonesulfonic acid
Identifiers
CAS Number	88-46-0 ;
3D model (JSmol)	Interactive image ;
ChEBI	CHEBI:71157 ;
ChEMBL	ChEMBL1232131 ;
ChemSpider	16554 ;
DrugBank	DB13529 ;
ECHA InfoCard	100.001.667
EC Number	201-833-4;
PubChem CID	17507 ;
UNII	TO0PAT081I ;
CompTox Dashboard (EPA)	DTXSID8045014 ;
	InChI InChI=1S/C6H6O5S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3,7-8H,(H,9,10,11) Key: IKQCSJBQLWJEPU-UHFFFAOYSA-N;
	SMILES C1=CC(=C(C=C1O)S(=O)(=O)O)O;
Properties
Chemical formula	C6H6O5S
Molar mass	190.17 g·mol−1
Related compounds
Other cations	Calcium dobesilate
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Last updated October 01, 2025

Dobesilic acid is a chemical compound with the molecular formula C₆H₆O₅S. It is classified as both a phenol and a sulfonic acid.

Uses

Salts of dobesilic are used as pharmaceutical drugs. The calcium salt, calcium dobesilate, is used as a vasoprotective drug.^[1]^[2] The diethylamine salt, etamsylate, is an antihemorrhagic agent.^[3]

References

↑ Zhang X, Liu W, Wu S, Jin J, Li W, Wang N (January 2015). "Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis". Science China Life Sciences. 58 (1): 101–7. doi: 10.1007/s11427-014-4792-1 . PMID 25528255.
↑ Haller H, Ji L, Stahl K, Bertram A, Menne J (2017). "Molecular Mechanisms and Treatment Strategies in Diabetic Nephropathy: New Avenues for Calcium Dobesilate-Free Radical Scavenger and Growth Factor Inhibition". BioMed Research International. 2017 1909258. doi: 10.1155/2017/1909258 . PMC 5634607 . PMID 29082239.
↑ Schulte J, Osborne J, Benson JW, Cooke R, Drayton M, Murphy J, et al. (January 2005). "Developmental outcome of the use of etamsylate for prevention of periventricular haemorrhage in a randomised controlled trial". Archives of Disease in Childhood. Fetal and Neonatal Edition. 90 (1): F31 –F35. doi:10.1136/adc.2003.035790. PMC 1721806 . PMID 15613570.

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[1] Zhang X, Liu W, Wu S, Jin J, Li W, Wang N (January 2015). "Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis". Science China Life Sciences. 58 (1): 101–7. doi: 10.1007/s11427-014-4792-1 . PMID 25528255.

[2] Haller H, Ji L, Stahl K, Bertram A, Menne J (2017). "Molecular Mechanisms and Treatment Strategies in Diabetic Nephropathy: New Avenues for Calcium Dobesilate-Free Radical Scavenger and Growth Factor Inhibition". BioMed Research International. 2017 1909258. doi: 10.1155/2017/1909258 . PMC 5634607 . PMID 29082239.

[pmid15613570-3] Schulte J, Osborne J, Benson JW, Cooke R, Drayton M, Murphy J, et al. (January 2005). "Developmental outcome of the use of etamsylate for prevention of periventricular haemorrhage in a randomised controlled trial". Archives of Disease in Childhood. Fetal and Neonatal Edition. 90 (1): F31 –F35. doi:10.1136/adc.2003.035790. PMC 1721806 . PMID 15613570.

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Names

IUPAC name 2,5-Dihydroxybenzenesulfonic acid
Other names Hydroquinonesulfonic acid
Identifiers
CAS Number	88-46-0
3D model (JSmol)	Interactive image
ChEBI	CHEBI:71157
ChEMBL	ChEMBL1232131
ChemSpider	16554
DrugBank	DB13529
ECHA InfoCard	100.001.667
EC Number	201-833-4
PubChem CID	17507
UNII	TO0PAT081I
CompTox Dashboard (EPA)	DTXSID8045014
InChI InChI=1S/C6H6O5S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3,7-8H,(H,9,10,11) Key: IKQCSJBQLWJEPU-UHFFFAOYSA-N
SMILES C1=CC(=C(C=C1O)S(=O)(=O)O)O
Properties
Chemical formula	C₆H₆O₅S
Molar mass	190.17 g·mol⁻¹
Related compounds
Other cations	Calcium dobesilate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references