Donglei Fan

Last updated
Donglei "Emma" Fan
NationalityAmerican
Alma mater Johns Hopkins University, Nanjing University
AwardsNational Science Foundation CAREER Award
Scientific career
Fields Nanomotors, nanorobotics, biosensing, biomolecule release, assembly, nanomanufacturing, and nanoporous materials
Institutions The University of Texas at Austin
Doctoral advisor Chia-Ling Chien and Robert C. Cammarata
External videos
Nuvola apps kaboodle.svg Texas Engineers Build World's Smallest, Fastest Nanomotor, Cockrell School of Engineering

Donglei "Emma" Fan is an associate professor of Mechanical Engineering of the Cockrell School of Engineering at The University of Texas at Austin and the principal investigator in its Nanomaterials Innovation Lab. In 2014, her team built a nanomotor that was significantly smaller, faster, and longer running than any previously designed. [1] [2] The techniques that they developed have been referred to as a "breakthrough technology". [3] The achievement was noted as a highlight of 2014 in Science Year by Year (2017). [4]

Contents

Early life and education

Fan attended Nanjing University (NJU) as part of an honor program for gifted youth, the Department of Intensive Instruction, as an early admitted student, waived the National College Entrance Exam and awarded the Freshman Merit Scholarship. She received her bachelor's degree in chemistry from NJU in 1999. [5]

She then attended Johns Hopkins University (JHU), from which she received two master's degrees, in materials science and engineering (2003) and in electrical engineering (2005). She went on to receive her Doctor of Philosophy degree in materials science and engineering from JHU in 2007. She was a postdoctoral fellow at JHU from 2007 to 2009. [5]

Career

In 2010, Fan joined The University of Texas at Austin as an assistant professor in the Department of Mechanical Engineering. [6] She is the principal investigator in its Nanomaterial Innovation Lab. [7] In 2012, Fan received the prestigious National Science Foundation (NSF) CAREER Award. In 2013, Fan was one of sixty engineers from Europe and the United States who were invited to participate in the EU-US Frontier of Engineering Symposium in France, supported by the National Academy of Engineering (NAE). In 2014, Fan was selected to participate in the Arab-American Frontiers of Science, Engineering, and Medicine Symposium, organized by the National Academy of Sciences (NAS). [5] In 2016, Fan was promoted to associate professor with tenure. In 2017, Fan received a Robert & Jane Mitchell Endowed Faculty Fellowship in Engineering. [7]

Donglei Fan is on the editorial board of the Scientific Reports. [8]

Research

Donglei Fan studies nanoelectromechanical systems (NEMS), in particular the design, assembly and control of rotary NEMS or nanomotors.

She and her coworkers have identified fundamental interactions at the nanoscale level and developed novel mechanisms for manipulating nanoscale components to create and control nanomotors. [9] [10]

The techniques developed have been described as a "breakthrough technology". [3]

While at Johns Hopkins University, she helped to develop a technique for moving and positioning nanostructures using alternating and constant electric fields. Applied using lithographically patterned electrodes, the orientation of the nanowire is controlled by the alternating fields while the direction of translation is controlled by the constant fields. The technique has been referred to as "electric tweezers". [11] [12] At the University of Texas at Austin, Fan has used this approach to move components and construct and manipulate nanomotors. [2]

Fan's approach has enabled her team to design and build nanomotors that are substantially smaller, faster, and longer lasting than previous nanomotors. [1] [2] In Nature Communications (2014), they describe the bottom-up assembly of arrays of nanomotors. Each nanomotor consists of only three parts: a quadrupole microelectrode for a stator, a nanomagnet for a bearing, and a nanowire for a rotor. [1] [5] [13]

The resulting nanomotor is less than 1 micrometer in all dimensions, making it 1/500th the size of a grain of table salt. Significantly, it is small enough to fit inside a human cell. [1] It is able to spin at much higher speeds than previous nanomotors. It can run at speeds up to 18,000 rpm, comparable to the rate of a jet engine. The duration of rotation such nanomotor is as long as 15 hours. [1] With a titanium nanobearing, one can run for as long as 80 hours with a total 1.1 million rotation cycles. [2] Previous nanomotors could run at 500 rpm or less for seconds or minutes. [1]

The speed and direction of the nanomotor's movement through liquid can be controlled using electric tweezers. [2] Experimenters were able to turn the nanomotors on and off and cause their rotation to occur in either a clockwise or counterclockwise direction. They were able to arrange the nanomotors in a pattern and direct their movements in a synchronized way. [14] Raman spectroscopy can be used to quantitatively monitor the placement of the nanomotors and their rate of rotation in real-time. [2]

Fan's nanomotor is the first to be capable of releasing a drug from its surface at a controllable rate. [1] [2] The surface of the rotor can be coated with a biochemical, which will be released in accordance with fluid boundary layer theory as the rotor spins. [2] As the rotor moves faster, more of the biochemical is released, [1] Potential applications as a controllable drug delivery mechanism include moving through the body to deliver insulin in diabetes, and attacking individual cancer cells. [1]

Fan has applied for a number of patents relating to this technology, several of which have been granted. [15]

Fan is also involved in studying microscale step-motors, [5] chemical sensing, [14] control of energy transfer in quantum dots using Förster resonance energy transfer, [5] and three dimensional nanoporous materials. [16]

Awards and honors

Related Research Articles

<span class="mw-page-title-main">Nanotechnology</span> Field of science involving control of matter on atomic and (supra)molecular scales

Nanotechnology is the manipulation of matter with at least one dimension sized from 1 to 100 nanometers (nm). At this scale, commonly known as the nanoscale, surface area and quantum mechanical effects become important in describing properties of matter. This definition of nanotechnology includes all types of research and technologies that deal with these special properties. It is common to see the plural form "nanotechnologies" as well as "nanoscale technologies" to refer to research and applications whose common trait is scale. An earlier understanding of nanotechnology referred to the particular technological goal of precisely manipulating atoms and molecules for fabricating macroscale products, now referred to as molecular nanotechnology.

Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology such as biological machines. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials.

<span class="mw-page-title-main">Nanoelectromechanical systems</span> Class of devices for nanoscale functionality

Nanoelectromechanical systems (NEMS) are a class of devices integrating electrical and mechanical functionality on the nanoscale. NEMS form the next logical miniaturization step from so-called microelectromechanical systems, or MEMS devices. NEMS typically integrate transistor-like nanoelectronics with mechanical actuators, pumps, or motors, and may thereby form physical, biological, and chemical sensors. The name derives from typical device dimensions in the nanometer range, leading to low mass, high mechanical resonance frequencies, potentially large quantum mechanical effects such as zero point motion, and a high surface-to-volume ratio useful for surface-based sensing mechanisms. Applications include accelerometers and sensors to detect chemical substances in the air.

<span class="mw-page-title-main">Nanomotor</span> Molecular device capable of converting energy into movement

A nanomotor is a molecular or nanoscale device capable of converting energy into movement. It can typically generate forces on the order of piconewtons.

<span class="mw-page-title-main">Nanochemistry</span> Combination of chemistry and nanoscience

Nanochemistry is an emerging sub-discipline of the chemical and material sciences that deals with the development of new methods for creating nanoscale materials. The term "nanochemistry" was first used by Ozin in 1992 as 'the uses of chemical synthesis to reproducibly afford nanomaterials from the atom "up", contrary to the nanoengineering and nanophysics approach that operates from the bulk "down"'. Nanochemistry focuses on solid-state chemistry that emphasizes synthesis of building blocks that are dependent on size, surface, shape, and defect properties, rather than the actual production of matter. Atomic and molecular properties mainly deal with the degrees of freedom of atoms in the periodic table. However, nanochemistry introduced other degrees of freedom that controls material's behaviors by transformation into solutions. Nanoscale objects exhibit novel material properties, largely as a consequence of their finite small size. Several chemical modifications on nanometer-scaled structures approve size dependent effects.

<span class="mw-page-title-main">Charles M. Lieber</span> American chemist (born 1959)

Charles M. Lieber is an American chemist, inventor, nanotechnologist, and writer. In 2011, Lieber was named the leading chemist in the world for the decade 2000–2010 by Thomson Reuters, based on the impact of his scientific publications. He is known for his contributions to the synthesis, assembly and characterization of nanoscale materials and nanodevices, the application of nanoelectronic devices in biology, and as a mentor to numerous leaders in nanoscience.

The following outline is provided as an overview of and topical guide to nanotechnology:

<span class="mw-page-title-main">Nanomechanics</span>

Nanomechanics is a branch of nanoscience studying fundamental mechanical properties of physical systems at the nanometer scale. Nanomechanics has emerged on the crossroads of biophysics, classical mechanics, solid-state physics, statistical mechanics, materials science, and quantum chemistry. As an area of nanoscience, nanomechanics provides a scientific foundation of nanotechnology.

Green nanotechnology refers to the use of nanotechnology to enhance the environmental sustainability of processes producing negative externalities. It also refers to the use of the products of nanotechnology to enhance sustainability. It includes making green nano-products and using nano-products in support of sustainability.

A device generating linear or rotational motion using carbon nanotube(s) as the primary component, is termed a nanotube nanomotor. Nature already has some of the most efficient and powerful kinds of nanomotors. Some of these natural biological nanomotors have been re-engineered to serve desired purposes. However, such biological nanomotors are designed to work in specific environmental conditions. Laboratory-made nanotube nanomotors on the other hand are significantly more robust and can operate in diverse environments including varied frequency, temperature, mediums and chemical environments. The vast differences in the dominant forces and criteria between macroscale and micro/nanoscale offer new avenues to construct tailor-made nanomotors. The various beneficial properties of carbon nanotubes makes them the most attractive material to base such nanomotors on.

<span class="mw-page-title-main">Nanoscale plasmonic motor</span>

A nanoscale plasmonic motor is a type of nanomotor, converting light energy to rotational motion at nanoscale. It is constructed from pieces of gold sheet in a gammadion shape, embedded within layers of silica. When irradiated with light from a laser, the gold pieces rotate. The functioning is explained by the quantum concept of the plasmon. This type of nanomotor is much smaller than other types, and its operation can be controlled by varying the frequency of the incident light.

Nanshu Lu is an associate professor at the University of Texas at Austin where she leads the Lu Research Group in the department of aerospace engineering and engineering mechanics. She also holds a courtesy appointment in the department of biomedical engineering. Lu is recognized for her work on the integration of electronics into stretchable materials compatible with human tissue, for which she was named one of the Top 35 innovators under the age of 35 by the MIT Technology Review in 2012.

<span class="mw-page-title-main">Christy Haynes</span> American analytical chemist

Christy Lynn Haynes is a chemist at the University of Minnesota. She works at the interface of analytical, biological, and nanomaterials chemistry.

Delia J. Milliron is the T. Brockett Hudson Professor in Chemical Engineering at the University of Texas at Austin. Milliron leads a research team that focuses on developing and studying the properties of new electronic nanomaterials. Her team pursues studies on nanocrystals, nanoscale interfaces, and controlled assemblies of nanocrystals. Her team takes a systematic approach towards elucidating effects that arise at the nanoscale with a special focus on structure-property relationships.

Nathan C. Gianneschi is the Jacob & Rosaline Cohn Professor of Chemistry, Materials Science & Engineering, and Biomedical Engineering at Northwestern University and the Associate Director for the International Institute for Nanotechnology. Gianneschi's lab takes an interdisciplinary approach to nanomaterials research, with a focus on multifunctional materials for biomedical applications, programmed interactions with biomolecules and cells, and basic research into nanoscale materials design, synthesis and characterization.

<span class="mw-page-title-main">Yi Cui (scientist)</span> Chinese-American scientist (born 1976)

Yi Cui is a Chinese-American scientist specializing in the fields of nanotechnology, materials science, sustainable energy, and chemistry. Cui is Fortinet Founders Professor at Stanford University, where he also serves as a professor of materials science and engineering and of energy science and engineering. He is a Highly Cited Researcher in the fields of materials science, environment and ecology, engineering, and chemistry as of 2023. From 2020 to 2023, Cui was the director of the Precourt Institute for Energy, and since 2023 he has served as the inaugural faculty director of the Sustainability Accelerator in the Doerr School of Sustainability.

Elisa Riedo is a physicist and researcher known for her contributions in condensed matter physics, nanotechnology and engineering. She is the Herman F. Mark Chair Professor of Chemical and Biomolecular Engineering at the New York University Tandon School of Engineering and the director of the picoForce Lab.

<span class="mw-page-title-main">Aleksandra Radenovic</span> Swiss-Croatian bioengineer

Aleksandra Radenovic is a Swiss and Croatian biophysicist. Her research focuses on the development of experimental tools to study single-molecule biophysics. She is a professor of biological engineering at the École Polytechnique Fédérale de Lausanne (EPFL) and head of the Laboratory of Nanoscale Biology.

Joan M. Redwing is an American materials scientist known for research on electronic and optoelectronic materials, including the processing of semiconductor thin films and nanomaterials by metalorganic chemical vapor deposition (MOCVD). Redwing is a distinguished professor of materials science and engineering and electrical engineering at Pennsylvania State University and director of the university's 2D Crystal Consortium research facility. She is a fellow of the American Association for the Advancement of Science, the American Physical Society, and the Materials Research Society.

References

  1. 1 2 3 4 5 6 7 8 9 Algar, Jim (21 May 2014). "World's smallest and fastest nanomotor created by UT-Austin scientists will blow you away". Tech Times. Retrieved 1 January 2018.
  2. 1 2 3 4 5 6 7 8 Glückstad, Jesper; Palima, Darwin (30 May 2017). Light Robotics - Structure-mediated Nanobiophotonics (1st ed.). Elsevier. pp. 150–155. ISBN   9780702070969 . Retrieved 2 January 2018.
  3. 1 2 "Attack of the (cancer) killer nanobot". Women in Nanoscience. May 28, 2014.
  4. Science Year by Year: A Visual History, From Stone Tools to Space Travel. DK Children. March 7, 2017. p. 243. ISBN   9781465465337 . Retrieved 2 January 2018.
  5. 1 2 3 4 5 6 "Dr. Donglei Fan: High Performance Nanomotors". Texas Materials Institute. September 3, 2015. Archived from the original on January 11, 2018. Retrieved January 2, 2018.
  6. "Welcome New Faculty, Drs. Fan, Li and Sentis". UT News. February 24, 2010. Retrieved 5 January 2018.
  7. 1 2 3 "People in Dr. Fan's Lab". The Nanomaterial Innovation Lab. Retrieved 3 January 2018.
  8. "Editorial Board". Scientific Reports. Retrieved 3 January 2018.
  9. 1 2 Lindstrom, Ashley (August 16, 2012). "Assistant Professors Donglei Fan and Carlos Hidrovo receive NSF CAREER Awards for new projects". UTI News. Retrieved 4 January 2018.
  10. 1 2 "CAREER: Novel Mechanism for Assembling Large Arrays of Rotary Nano- Electromechanical Devices Using Nanoscale Building Blocks". National Science Foundation. Retrieved 3 January 2018.
  11. Hilmer, Andrew J.; Strano, Michael S. (13 June 2010). "Nanowires have cells in their sights". Nature Nanotechnology. 5 (7): 481–482. doi:10.1038/nnano.2010.133. PMID   20543833.
  12. Fan, Donglei; Yin, Zhizhong; Cheong, Raymond; Zhu, Frank Q.; Cammarata, Robert C.; Chien, C. L.; Levchenko, Andre (13 June 2010). "Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires". Nature Nanotechnology. 5 (7): 545–551. Bibcode:2010NatNa...5..545F. doi:10.1038/nnano.2010.104. PMC   3118461 . PMID   20543835.
  13. Kim, Kwanoh; Xu, Xiaobin; Guo, Jianhe; Fan, D. L. (7 April 2014). "Ultrahigh-speed rotating nanoelectromechanical system devices assembled from nanoscale building blocks". Nature Communications. 5: 3632. arXiv: 1402.4185 . Bibcode:2014NatCo...5.3632K. doi:10.1038/ncomms4632. PMID   24709694. S2CID   205324675.
  14. 1 2 "Engineers Build World's Smallest, Fastest Nanomotor". UT News. May 20, 2014. Retrieved 5 January 2018.
  15. "Patents by Inventor Donglei Fan". Justia Patents. Retrieved 3 January 2018.
  16. Li, Weigu; Tekell, Marshall C.; Liu, Chang; Hethcock, Jacob A.; Fan, Donglei (2018-05-22). "Flexible All-Solid-State Supercapacitors of High Areal Capacitance Enabled by Porous Graphite Foams with Diverging Microtubes". Advanced Functional Materials. 28 (29): 1800601. doi:10.1002/adfm.201800601. ISSN   1616-301X. S2CID   103658338.
  17. 1 2 "Donglei Fan Associate Professor". Department of Mechanical Engineering, Cockrell School of Engineering The University of Texas at Austin. Retrieved 3 January 2018.