ERH (gene)

ERH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W9G, 2NML
Identifiers
Aliases	ERH , DROER, enhancer of rudimentary homolog (Drosophila), mRNA splicing and mitosis factor, ERH mRNA splicing and mitosis factor
External IDs	OMIM: 601191 MGI: 108089 HomoloGene: 3274 GeneCards: ERH
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.1 Start 69,380,128 bp [1] End 69,398,299 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 80,680,796 bp [2] End 80,691,115 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula embryo ganglionic eminence lactiferous duct renal medulla caput epididymis islet of Langerhans retinal pigment epithelium corpus epididymis pylorus Top expressed in yolk sac morula lip esophagus ganglionic eminence superior frontal gyrus spermatocyte hand thymus mirror More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyl-CpG binding protein binding RNA binding Cellular component methylosome midbody Biological process pyrimidine nucleoside metabolic process cell cycle nucleobase-containing compound metabolic process pyrimidine nucleotide biosynthetic process positive regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2079 13877 Ensembl ENSG00000100632 ENSMUSG00000021131 UniProt P84090 P84089 RefSeq (mRNA) NM_004450 NM_007951 NM_001347409 RefSeq (protein) NP_004441 NP_001334338 NP_031977 Location (UCSC) Chr 14: 69.38 – 69.4 Mb Chr 12: 80.68 – 80.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Enhancer of rudimentary
crystal structure of enhancer of rudimentary homologue (erh)
Identifiers
Symbol	ER
Pfam	PF01133
InterPro	IPR000781
PROSITE	PDOC00732
SCOP2	1j24 / SCOPe / SUPFAM
TCDB	3.A.16
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene. ^{[5] [6] [7]}

The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis. ^[8]

From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms. ^[6] It has been proposed that this protein plays a role in the cell cycle.

References

1. GRCh38: Ensembl release 89: ENSG00000100632 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021131 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (Sep 1996). "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene". Genomics. 32 (1): 125–7. doi:10.1006/geno.1996.0086. PMID   8786099.
6. Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI (Apr 1997). "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene. 186 (2): 189–95. doi:10.1016/S0378-1119(96)00701-9. PMID   9074495.
7. "Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)".
8. Wojcik, E.; Murphy, A. M.; Fares, H.; Dang-Vu, K.; Tsubota, S. I. (1994). "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene". Genetics. 138 (4): 1163–1170. doi:10.1093/genetics/138.4.1163. PMC   1206255 . PMID   7896098.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi: 10.1016/j.febslet.2004.12.045 . PMID   15670829. S2CID   33475235.
• Wan C, Tempel W, Liu ZJ, et al. (2005). "Structure of the conserved transcriptional repressor enhancer of rudimentary homolog". Biochemistry. 44 (13): 5017–23. doi:10.1021/bi047785w. PMID   15794639.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Jin T, Guo F, Serebriiskii IG, et al. (2007). "A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks". Proteins. 68 (2): 427–37. doi: 10.1002/prot.21343 . PMID   17444515. S2CID   2003248.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Enhancer of rudimentary homolog (ERH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Enhancer of rudimentary homolog (ERH)

This article incorporates text from the public domain Pfam and InterPro: IPR000781