ERH (gene)

Last updated
ERH
Protein ERH PDB 1w9g.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ERH , DROER, enhancer of rudimentary homolog (Drosophila), mRNA splicing and mitosis factor, ERH mRNA splicing and mitosis factor
External IDs OMIM: 601191 MGI: 108089 HomoloGene: 3274 GeneCards: ERH
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004450

NM_007951
NM_001347409

RefSeq (protein)

NP_004441

NP_001334338
NP_031977

Location (UCSC) Chr 14: 69.38 – 69.4 Mb Chr 12: 80.68 – 80.69 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse
Enhancer of rudimentary
PDB 1wz7 EBI.jpg
crystal structure of enhancer of rudimentary homologue (erh)
Identifiers
SymbolER
Pfam PF01133
InterPro IPR000781
PROSITE PDOC00732
SCOP2 1j24 / SCOPe / SUPFAM
TCDB 3.A.16
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene. [5] [6] [7]

Contents

The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis. [8]

From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms. [6] It has been proposed that this protein plays a role in the cell cycle.


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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100632 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021131 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (Sep 1996). "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene". Genomics. 32 (1): 125–7. doi:10.1006/geno.1996.0086. PMID   8786099.
  6. 1 2 Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI (Apr 1997). "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene. 186 (2): 189–95. doi:10.1016/S0378-1119(96)00701-9. PMID   9074495.
  7. "Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)".
  8. Wojcik, E.; Murphy, A. M.; Fares, H.; Dang-Vu, K.; Tsubota, S. I. (1994). "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene". Genetics. 138 (4): 1163–1170. doi:10.1093/genetics/138.4.1163. PMC   1206255 . PMID   7896098.

Further reading



This article incorporates text from the public domain Pfam and InterPro: IPR000781