Names | |
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Preferred IUPAC name (4S)-2-Methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid | |
Other names
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Identifiers | |
3D model (JSmol) | |
ChEBI | |
ChemSpider | |
KEGG | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C6H10N2O2 | |
Molar mass | 142.158 g·mol−1 |
Appearance | White powder |
Density | 1.568 g/cm3 |
Soluble in water | |
Hazards | |
NFPA 704 (fire diamond) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a natural compound found in several species of bacteria. It is a compatible solute which serves as a protective substance by acting as an osmolyte and thus helps organisms survive extreme osmotic stress. Ectoine is found in high concentrations in halophilic microorganisms and confers resistance towards salt and temperature stress. Ectoine was first identified in the microorganism Ectothiorhodospira halochloris, [3] [4] but has since been found in a wide range of Gram-negative and Gram-positive bacteria. Other species of bacteria in which ectoine was found include:
Ectoine is synthesized in three successive enzymatic reactions starting from aspartic β-semialdehyde. The genes involved in the biosynthesis are called ectA, ectB and ectC, and they encode the enzymes L-2,4-diaminobutyric acid acetyltransferase, L-2,4-diaminobutyric acid transaminase and L-ectoine synthase, respectively. [6] [5]
Ectoine is used as an active ingredient in skin care and sun protection products. [11] It stabilizes proteins and other cellular structures and protects the skin from stresses like UV irradiation and dryness. [5]
Due to its protein stabilizing properties, ectoine has been evaluated as a topical treatment for hay fever. Effectiveness of a nasal spray containing ectoine is comparable to cromoglycate and is reported to be well tolerated by the patients. [12] It is available over-the-counter in European Union.
A halophile is an extremophile that thrives in high salt concentrations. In chemical terms, halophile refers to a Lewis acidic species that has some ability to extract halides from other chemical species.
Halotolerance is the adaptation of living organisms to conditions of high salinity. Halotolerant species tend to live in areas such as hypersaline lakes, coastal dunes, saline deserts, salt marshes, and inland salt seas and springs. Halophiles are organisms that live in highly saline environments, and require the salinity to survive, while halotolerant organisms can grow under saline conditions, but do not require elevated concentrations of salt for growth. Halophytes are salt-tolerant higher plants. Halotolerant microorganisms are of considerable biotechnological interest.
Halomonadaceae is a family of halophilic Pseudomonadota.
Food microbiology is the study of the microorganisms that inhabit, create, or contaminate food. This includes the study of microorganisms causing food spoilage; pathogens that may cause disease ; microbes used to produce fermented foods such as cheese, yogurt, bread, beer, and wine; and microbes with other useful roles, such as producing probiotics.
The enzyme ectoine synthase (EC ) catalyzes the chemical reaction
In enzymology, a diaminobutyrate acetyltransferase (EC 2.3.1.178) is an enzyme that catalyzes the chemical reaction
In enzymology, a diaminobutyrate-2-oxoglutarate transaminase is an enzyme that catalyzes the chemical reaction
Osmoprotectants or compatible solutes are small organic molecules with neutral charge and low toxicity at high concentrations that act as osmolytes and help organisms survive extreme osmotic stress. Osmoprotectants can be placed in three chemical classes: betaines and associated molecules, sugars and polyols, and amino acids. These molecules accumulate in cells and balance the osmotic difference between the cell's surroundings and the cytosol. In plants, their accumulation can increase survival during stresses such as drought. In extreme cases, such as in bdelloid rotifers, tardigrades, brine shrimp, and nematodes, these molecules can allow cells to survive being completely dried out and let them enter a state of suspended animation called cryptobiosis.
Pyoverdines are fluorescent siderophores produced by certain pseudomonads. Pyoverdines are important virulence factors, and are required for pathogenesis in many biological models of infection. Their contributions to bacterial pathogenesis include providing a crucial nutrient, regulation of other virulence factors, supporting the formation of biofilms, and are increasingly recognized for having toxicity themselves.
Halomonas titanicae is a gram-negative, halophilic species of bacteria which was isolated in 2010 from rusticles recovered from the wreck of the RMS Titanic. It has been estimated by Henrietta Mann, one of the researchers that first isolated it, that the action of microbes like Halomonas titanicae may bring about the total deterioration of the Titanic by 2030. While the bacteria have been identified as a potential danger to oil rigs and other man-made objects in the deep sea, they also have the potential to be used in bioremediation to accelerate the decomposition of shipwrecks littering the ocean floor.
Deleya halophila is a salt-loving, gram-negative bacteria. It is known to habitat marine environments, solar salterns, saline soils, and salted food. The genus was named after J. De Ley, a noted biologist. Its type strain is CCM 3662.
Halobacillus trueperi is a species of bacteria. It is halophilic, gram-positive, heterotrophic and its type strain is DSM 10404T.
Halomonas ventosae is a moderately halophilic, denitrifying, exopolysaccharide-producing bacterium. Its type strain is Al12T.
Persephonella marina is a Gram-negative, rod shaped bacteria that is a member of the Aquificota phylum. Stemming from Greek, the name Persephonella is based upon the mythological goddess Persephone. Marina stems from a Latin origin, meaning "belonging to the sea". It is a thermophile with an obligate chemolithoautotrophic metabolism. Growth of P. marina can occur in pairs or individually, but is rarely seen aggregating in large groups. The organism resides on sulfidic chimneys in the deep ocean and has never been documented as a pathogen.
Halomonas anticariensis is a bacterium. It is strictly aerobic and because of its production of exopolysaccharides forms cream-coloured, mucoid colonies. FP35T is the type strain. Its genome has been sequenced.
Halorhodospira halophila is a species of Halorhodospira distinguished by its ability to grow optimally in an environment of 15–20% salinity. It was formerly called Ectothiorhodospira halophila. It is an anaerobic, rod-shaped Gram-negative bacterium. H. halophila has a flagellum.
Guyparkeria is a genus in the Gammaproteobacteria. Both species are obligate aerobic bacteria; they require oxygen to grow. They are also halophilic and have varying degrees of thermophilicity. They live in environments with high concentrations of salt or other solutes, such as in hydrothermal vent plumes or in hypersaline playas, and do require high sodium ion concentrations in order to grow, as is also the case in the other genus of the same family, Thioalkalibacter
Marinococcus halophilus is a Gram-positive and halophilic bacterium from the genus of Marinococcus which has been isolated from a salted mackerel. Marinococcus halophilus produces ectoine.
Halomonas elongata is considered the type species of the genus Halomonas. It is a chemoorganotrophic, halophilic bacterium first isolated from a solar salt facility located in Bonaire, Netherlands Antilles.
Halorhodospira neutriphila is a bacterium from the genus of Halorhodospira which has been isolated from a microbial mat from a marine saltern from Rhone Delta in France. The microbial mat forms at the sediment surface and is between 10 and 20 mm thick, below a fine layer (2–3 cm) of gypsum crust. The mat is composed of a red layer of purple bacteria strains below a green layer of cyanobacteria, interspersed with sulfur globules, and occasionally covered by halite deposits. These mat forming microbes live in anoxic muds and sediments and form a benthic mat in a hypersaline lagoon environment where the salinity of the water ranges from 240-320‰ of total salinity. H. neutriphila was isolated from the red layer of the microbial layer and found to be extremely halophilic and well adapted to withstand the extreme saline conditions of their modified marine habitat. The type strain was identified as strain SG 3301T.